Zhu J et al. |
Protective effects of Hand.- Mazz. (EBHM) extract in retinal neurodegeneration models. |
2018 |
Mol. Vis. |
pmid:29769797
|
Amiri M et al. |
Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice. |
2018 |
Phytother Res |
pmid:29748995
|
Oliveira DR et al. |
Flavones-bound in benzodiazepine site on GABA receptor: Concomitant anxiolytic-like and cognitive-enhancing effects produced by Isovitexin and 6-C-glycoside-Diosmetin. |
2018 |
Eur. J. Pharmacol. |
pmid:29738701
|
Dang Y et al. |
Protective Effect of Apigenin on Acrylonitrile-Induced Inflammation and Apoptosis in Testicular Cells via the NF-κB Pathway in Rats. |
2018 |
Inflammation |
pmid:29687413
|
Yang YC and Wei MC |
Development and characterization of a green procedure for apigenin extraction from Scutellaria barbata D. Don. |
2018 |
Food Chem |
pmid:29478557
|
Witkowska-Banaszczak E |
Flavonoids from Trollius europaeus flowers and evaluation of their biological activity. |
2018 |
J. Pharm. Pharmacol. |
pmid:29466602
|
Jin UH et al. |
Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. |
2018 |
Toxicol. Sci. |
pmid:29584932
|
Xin Z et al. |
UPLC-Orbitrap-MS/MS combined with chemometrics establishes variations in chemical components in green tea from Yunnan and Hunan origins. |
2018 |
Food Chem |
pmid:30381222
|
Mendel M et al. |
Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study. |
2018 |
J. Vet. Pharmacol. Ther. |
pmid:28913883
|
Li Y et al. |
Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. |
2018 |
Toxicol. Lett. |
pmid:29753067
|
Chassagne F et al. |
A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. |
2018 |
Fitoterapia |
pmid:29477305
|
van Vugt-Lussenburg BMA et al. |
Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity. |
2018 |
Reprod. Toxicol. |
pmid:29162470
|
Xu L et al. |
Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects. |
2018 |
J. Exp. Clin. Cancer Res. |
pmid:30373602
|
Kang CH et al. |
Apigenin promotes TRAIL-mediated apoptosis regardless of ROS generation. |
2018 |
Food Chem. Toxicol. |
pmid:29247770
|
Kowalczyk A et al. |
Insights into novel anticancer applications for apigenin. |
2017 |
Adv Clin Exp Med |
pmid:29211364
|
You L et al. |
Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. |
2017 |
Bioorg. Med. Chem. Lett. |
pmid:29157862
|
He X et al. |
Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat. |
2017 |
Am. J. Chin. Med. |
pmid:29121796
|
Pate KM et al. |
Anthoxanthin Polyphenols Attenuate Aβ Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease. |
2017 |
CNS Neurosci Ther |
pmid:27864869
|
Jin X et al. |
Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. |
2017 |
Int J Nanomedicine |
pmid:28761344
|
Seo HS et al. |
Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. |
2017 |
Oncol. Rep. |
pmid:28656316
|
Spilovska K et al. |
Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. |
2017 |
Molecules |
pmid:28621747
|
Salmani JMM et al. |
Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives. |
2017 |
Chin J Nat Med |
pmid:28558867
|
Elmasri WA et al. |
Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization. |
2017 |
J. Proteome Res. |
pmid:28541047
|
Yang PM et al. |
Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. |
2017 |
Oncotarget |
pmid:28526810
|
Zhong Y et al. |
Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. |
2017 |
Toxicon |
pmid:28734981
|
Elhennawy MG and Lin HS |
Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. |
2017 |
J Pharm Biomed Anal |
pmid:28494337
|
Alvin JW and Lacy DB |
Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. |
2017 |
J. Struct. Biol. |
pmid:28433497
|
Hicks DF et al. |
Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. |
2017 |
Sci Rep |
pmid:28256512
|
Min JW et al. |
Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. |
2017 |
Oncotarget |
pmid:28424420
|
Yang LL et al. |
Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. |
2017 |
Biochim Biophys Acta Mol Basis Dis |
pmid:27903431
|
Perrott KM et al. |
Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. |
2017 |
Geroscience |
pmid:28378188
|
Stump TA et al. |
The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. |
2017 |
J. Pharm. Pharmacol. |
pmid:28349530
|
Sun XP et al. |
Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. |
2017 |
Arch. Pharm. Res. |
pmid:28315259
|
Ferrazzi P et al. |
Pollination effects on antioxidant content of Perilla frutescens seeds analysed by NMR spectroscopy. |
2017 |
Nat. Prod. Res. |
pmid:28278651
|
Anusha C et al. |
Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. |
2017 |
Chem. Biol. Interact. |
pmid:28389404
|
Verma S et al. |
Natural polyphenolic inhibitors against the antiapoptotic BCL-2. |
2017 |
J. Recept. Signal Transduct. Res. |
pmid:28264627
|
Kalivarathan J et al. |
Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet. |
2017 |
Biomed. Pharmacother. |
pmid:28237914
|
Naik PM and Al-Khayri JM |
Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. |
2017 |
Methods Mol. Biol. |
pmid:28755356
|
Grigalius I and Petrikaite V |
Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. |
2017 |
Molecules |
pmid:29215574
|
Granato M et al. |
Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. |
2017 |
J. Exp. Clin. Cancer Res. |
pmid:29179721
|
Fan H et al. |
Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. |
2017 |
Med. Sci. Monit. |
pmid:29172017
|
Gu C et al. |
Preparation of Vitexin Nanoparticles by Combining the Antisolvent Precipitation and High Pressure Homogenization Approaches Followed by Lyophilization for Dissolution Rate Enhancement. |
2017 |
Molecules |
pmid:29165376
|
Liao M et al. |
Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. |
2017 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:29127056
|
Jeong KM et al. |
Identification of Major Flavone C-Glycosides and Their Optimized Extraction from Cymbidium kanran Using Deep Eutectic Solvents. |
2017 |
Molecules |
pmid:29156555
|
Medhat AM et al. |
Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. |
2017 |
Tumour Biol. |
pmid:29022496
|
Ganesan K and Xu B |
Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. |
2017 |
Ann. N. Y. Acad. Sci. |
pmid:28891090
|
Zhou RJ et al. |
Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. |
2017 |
Biochem. Biophys. Res. Commun. |
pmid:28867192
|
Shan S et al. |
Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. |
2017 |
J. Agric. Food Chem. |
pmid:28829588
|
Britto SM et al. |
Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. |
2017 |
Mutat. Res. |
pmid:28735741
|
Wen L et al. |
An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. |
2017 |
Molecules |
pmid:28486427
|
Jangdey MS et al. |
Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. |
2017 |
Drug Deliv |
pmid:28687053
|
Perez-Leal O et al. |
Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. |
2017 |
J. Biol. Chem. |
pmid:28684421
|
Hassoun SM et al. |
Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. |
2017 |
Tumour Biol. |
pmid:28651490
|
Sang Y et al. |
Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. |
2017 |
Food Funct |
pmid:28598487
|
Zhang L et al. |
Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. |
2017 |
Mol Med Rep |
pmid:28849116
|
Tu F et al. |
Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. |
2017 |
Med. Sci. Monit. |
pmid:28821706
|
Liu S and Ho PC |
Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. |
2017 |
J. Pharm. Pharmacol. |
pmid:28809432
|
Fallatah O and Georges E |
Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. |
2017 |
Int. J. Antimicrob. Agents |
pmid:28807879
|
Che Ahmad Tantowi NA et al. |
Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. |
2017 |
Menopause |
pmid:28640163
|
Li J et al. |
Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. |
2017 |
World J. Gastroenterol. |
pmid:28611514
|
Chen JL and Ko WC |
Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. |
2017 |
Eur. J. Pharmacol. |
pmid:28603044
|
Zhang Z et al. |
Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. |
2017 |
Drug Dev Ind Pharm |
pmid:28358225
|
Karim R et al. |
Development and evaluation of injectable nanosized drug delivery systems for apigenin. |
2017 |
Int J Pharm |
pmid:28456651
|
Han Y et al. |
Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. |
2017 |
J Clin Neurosci |
pmid:28342702
|
Soyman Z et al. |
Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. |
2017 |
Balkan Med J |
pmid:28443590
|
Bian M et al. |
Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. |
2017 |
Brain Res. |
pmid:28336272
|
Chen F et al. |
An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. |
2017 |
Ultrason Sonochem |
pmid:28427633
|
Crascì L et al. |
Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. |
2017 |
Planta Med. |
pmid:28288492
|
Zhang S et al. |
Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation. |
2017 |
Mol. Immunol. |
pmid:28288411
|
Zhao G et al. |
Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. |
2017 |
Oncol. Rep. |
pmid:28260058
|
Bolzon LB et al. |
Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems. |
2017 |
J. Inorg. Biochem. |
pmid:28236787
|
Liu HJ et al. |
Apigenin alleviates STZ-induced diabetic cardiomyopathy. |
2017 |
Mol. Cell. Biochem. |
pmid:28176247
|
Maher HM et al. |
Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS. |
2017 |
J Pharm Biomed Anal |
pmid:28167419
|
Wei X et al. |
Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. |
2017 |
Clin. Sci. |
pmid:28143892
|
Espargaró A et al. |
Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. |
2017 |
J. Nat. Prod. |
pmid:28128562
|
Zhou Z et al. |
Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. |
2017 |
Anticancer Drugs |
pmid:28125432
|
Erdogan S et al. |
The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. |
2017 |
Biomed. Pharmacother. |
pmid:28107698
|
Thirusangu P et al. |
Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. |
2017 |
Biochem. Biophys. Res. Commun. |
pmid:28104392
|
Yang N et al. |
Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. |
2017 |
Mol Med Rep |
pmid:28035355
|
Banerjee K et al. |
Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions. |
2017 |
J Colloid Interface Sci |
pmid:28012918
|
Wang F et al. |
Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. |
2017 |
Chem. Biol. Interact. |
pmid:28803762
|
Gaballah HH et al. |
Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. |
2017 |
Toxicol. Appl. Pharmacol. |
pmid:28025107
|
Hithamani G et al. |
Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells. |
2017 |
J. Biosci. |
pmid:29229878
|
Tseng TH et al. |
Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. |
2017 |
Environ. Toxicol. |
pmid:26872304
|
Ketkaew Y et al. |
Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. |
2017 |
Arch. Oral Biol. |
pmid:27886571
|
Liu H et al. |
Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. |
2017 |
J Chromatogr Sci |
pmid:27884870
|
Wu CY et al. |
Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration. |
2017 |
Curr. Med. Chem. |
pmid:27855618
|
Guo TT et al. |
Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. |
2017 |
J Asian Nat Prod Res |
pmid:27848262
|
Sharma N et al. |
Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativus Targeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena. |
2017 |
Med Chem |
pmid:27834134
|
Tang D et al. |
Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. |
2017 |
Expert Opin Drug Metab Toxicol |
pmid:27766890
|
Tan YQ et al. |
Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. |
2017 |
Mol. Cell. Biochem. |
pmid:27778136
|
Wen L et al. |
Identification of a flavonoid C-glycoside as potent antioxidant. |
2017 |
Free Radic. Biol. Med. |
pmid:28587909
|
Pápay ZE et al. |
Controlled Release Oral Delivery of Apigenin Containing Pellets with Antioxidant Activity. |
2017 |
Curr Drug Deliv |
pmid:27264725
|
Gutiérrez-Venegas G and González-Rosas Z |
Apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells. |
2017 |
Arch. Pharm. Res. |
pmid:27193174
|
Wong TY et al. |
Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. |
2017 |
Biomed. Pharmacother. |
pmid:29198743
|
Wang J et al. |
Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. |
2017 |
Int J Nanomedicine |
pmid:29158673
|
Hassan SM et al. |
Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. |
2017 |
Pharm Biol |
pmid:28064632
|
Salazar-Aguilar S et al. |
Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. |
2017 |
Nutrients |
pmid:28757593
|
Golea L et al. |
Phytochemical components and biological activities of Silene arenarioides Desf. |
2017 |
Nat. Prod. Res. |
pmid:28278644
|
Gómez-Zorita S et al. |
Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes. |
2017 |
J Transl Med |
pmid:29162103
|