| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yuan K et al. | [Simultaneous determination of four glycosylflavones from Lophatherum gracile by RP-HPLC]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166010 |
| Liu J and Xiong Y | [Advances in studies on pharmacokinetics of scutellarin and scutellarein]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20352990 |
| Ren DC et al. | [Chemical study on aerial parts of Ligusticum chuanxiong]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17966355 |
| Zhang S et al. | [Studies on chemical constituents of Eriophyton wallichii]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17639985 |
| Wang M et al. | [Studies on constituents of Dendrobium gratiosissimum]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17608224 |
| Dong Q et al. | [Studies on chemical constituents from stellaria media. I]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17672340 |
| Hu BB et al. | [Determination of main flavone glycosides in Flos Chrysanthemi and observation of factors influenced contents]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17260789 |
| Cheng YB et al. | [Study on chemical constituents in rhizome of Smilax perfoliate]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015307 |
| Zhao DB et al. | [Studies on chemical constituents in herb of Chondrilla piptocoma]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011281 |
| Zhang Y et al. | [Effect of caffeic acid, seopoletin and scutellarin on rat retinal neurons in vitro]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16124607 |
| Che QM et al. | [Study on bile excretion of scutellarein]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17225543 |
| Qu L et al. | [Determination of vitexin-rhamnoside in Beagle dog plasma and preliminary pharmacokinetics of Yixintong sustained release tablets]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18720869 |
| Huang Y et al. | [Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound hongcao for injection by UPLC-MS/MS]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22375405 |
| Han SL et al. | [Comparison of antioxidant activity between two species of chamomiles produced in Xinjiang by TLC-bioautography]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23672040 |
| Pang LL et al. | [Inhibitory effects of apigenin on the expression of GATA-3 and Th2 cytokines in asthmatic mice]. | 2010 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:20669675 |
| Guo LL et al. | [Effect of scutellarin on expressions of nicotinic acetylcholine receptor protein and mRNA in the brains of dementia rats]. | 2011 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:21823425 |
| Tian Y et al. | [The effect of apigenin on reproductive axis in female rats]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21845881 |
| Cehn YS et al. | [Studies on the lowering blood sugar substances from agrimony (II)]. | 2010 | Zhong Yao Cai | pmid:20873555 |
| Rao GX et al. | [Studies on the chemical constituents of the leaves of Polygonum multiflorum]. | 2009 | Zhong Yao Cai | pmid:19764327 |
| Tan XQ et al. | [Study on the flavonoids constituents of Trachelospermum jasminoides]. | 2010 | Zhong Yao Cai | pmid:20518306 |