| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mekawy AMM et al. | Apigenin pretreatment enhances growth and salinity tolerance of rice seedlings. | 2018 | Plant Physiol. Biochem. | pmid:29980098 |
| Lorizola IM et al. | Beet Stalks and Leaves ( L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice. | 2018 | Nutrients | pmid:29976910 |
| Ren K et al. | Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing Inflammation. | 2018 | Cell. Physiol. Biochem. | pmid:29975943 |
| Zhang Y et al. | Apigenin suppresses mouse peritoneal fibrosis by down-regulating miR34a expression. | 2018 | Biomed. Pharmacother. | pmid:29966983 |
| Lim H et al. | Flavonoids interfere with NLRP3 inflammasome activation. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29960001 |
| Xia Y et al. | Apigenin Suppresses the IL-1β-Induced Expression of the Urokinase-Type Plasminogen Activator Receptor by Inhibiting MAPK-Mediated AP-1 and NF-κB Signaling in Human Bladder Cancer T24 Cells. | 2018 | J. Agric. Food Chem. | pmid:29945448 |
| Wong TY et al. | Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters. | 2018 | J. Pharm. Pharmacol. | pmid:29943490 |
| Wang J et al. | Scutellarin enhances osteoblast proliferation and function via NF-κB-mediated CXCR4 induction. | 2018 | Gene | pmid:29936266 |
| Jiang PY et al. | Protective effects of apigenin on LPS-induced endometritis via activating Nrf2 signaling pathway. | 2018 | Microb. Pathog. | pmid:29928944 |
| Wong TY et al. | Traversal of the Blood-Brain Barrier by Cleavable l-Lysine Conjugates of Apigenin. | 2018 | J. Agric. Food Chem. | pmid:29923397 |
| Zhou Z et al. | Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway. | 2018 | Mol Med Rep | pmid:29901074 |
| Yang D et al. | Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line. | 2018 | Drug Des Devel Ther | pmid:29849451 |
| Bhattacharya S et al. | Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats. | 2018 | Nanomedicine | pmid:29802937 |
| Gu CB et al. | Characterization, culture medium optimization and antioxidant activity of an endophytic vitexin-producing fungus Dichotomopilus funicola Y3 from pigeon pea [Cajanus cajan (L.) Millsp.]. | 2018 | J. Appl. Microbiol. | pmid:29791772 |
| Ravisankar S et al. | Structural profile of soluble and bound phenolic compounds in teff (Eragrostis tef) reveals abundance of distinctly different flavones in white and brown varieties. | 2018 | Food Chem | pmid:29784316 |
| Zhu J et al. | Protective effects of Hand.- Mazz. (EBHM) extract in retinal neurodegeneration models. | 2018 | Mol. Vis. | pmid:29769797 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| Alzoman NZ et al. | CE-DAD Determination of Scutellarein and Caffeic Acid in Abelia triflora Crude Extract. | 2018 | J Chromatogr Sci | pmid:29750262 |
| Amiri M et al. | Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice. | 2018 | Phytother Res | pmid:29748995 |
| Oliveira DR et al. | Flavones-bound in benzodiazepine site on GABA receptor: Concomitant anxiolytic-like and cognitive-enhancing effects produced by Isovitexin and 6-C-glycoside-Diosmetin. | 2018 | Eur. J. Pharmacol. | pmid:29738701 |