apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Leukemia D007938 74 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Melanoma D008545 69 associated lipids
Colitis D003092 69 associated lipids
Neuroblastoma D009447 66 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Pain D010146 64 associated lipids
Weight Loss D015431 56 associated lipids
Nerve Degeneration D009410 53 associated lipids
Parkinson Disease D010300 53 associated lipids
Asthma D001249 52 associated lipids
Thrombosis D013927 49 associated lipids
Precancerous Conditions D011230 48 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Memory Disorders D008569 33 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Gao Y et al. Hepatic, gastric and intestinal first-pass effects of vitexin-2''-O-rhamnoside in rats by ultra-high-performance liquid chromatography. 2016 Biomed. Chromatogr. pmid:26031900
Kiraly AJ et al. Apigenin inhibits COX-2, PGE2, and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26802941
Veltmann M et al. Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. 2016 PLoS ONE pmid:26800359
Hu W et al. Apigenin-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock. 2016 Food Funct pmid:26750400
Brunschwig C et al. Chemical Composition and Antioxidant Activity of Euterpe oleracea Roots and Leaflets. 2016 Int J Mol Sci pmid:28036089
Tsaroucha AK et al. Intraperitoneal administration of apigenin in liver ischemia/reperfusion injury protective effects. 2016 Saudi J Gastroenterol pmid:27976636
Hwang SH et al. Simultaneous Ultra Performance Liquid Chromatography Determination and Antioxidant Activity of Linarin, Luteolin, Chlorogenic Acid and Apigenin in Different Parts of Compositae Species. 2016 Molecules pmid:27886116
Lee SW et al. Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis. 2016 PLoS ONE pmid:27851782
Basílio N et al. Analogs of Natural 3-Deoxyanthocyanins: O-Glucosides of the 4',7-Dihydroxyflavylium Ion and the Deep Influence of Glycosidation on Color. 2016 Int J Mol Sci pmid:27775619
Chen M et al. Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner. 2016 Sci Rep pmid:27752089
Schuster R et al. Cajanus cajan- a source of PPARγ activators leading to anti-inflammatory and cytotoxic effects. 2016 Food Funct pmid:27603115
He JD et al. Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway. 2016 Oncotarget pmid:27588401
Qin Y et al. Apigenin inhibits NF-κB and snail signaling, EMT and metastasis in human hepatocellular carcinoma. 2016 Oncotarget pmid:27203387
Hu Y et al. Synthetic investigation toward apigenin 5-O-glycoside camellianin B as well as the chemical structure revision. 2016 Org. Biomol. Chem. pmid:27145917
Hawrył A et al. TLC Profiles of Selected Cirsium Species with Chemometrics in Construction of Their Fingerprints. 2016 J Chromatogr Sci pmid:27130878
Yuan Y et al. Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia. 2016 Neuromolecular Med. pmid:27103430
Pérez-Montaño F et al. RNA-seq analysis of the Rhizobium tropici CIAT 899 transcriptome shows similarities in the activation patterns of symbiotic genes in the presence of apigenin and salt. 2016 BMC Genomics pmid:26951045
Cardenas H et al. Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function. 2016 Int J Mol Sci pmid:26938530
García-Martínez O et al. Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation. 2016 PLoS ONE pmid:26930190
Dong ZX et al. An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin. 2016 Molecules pmid:26927039
Cao HH et al. Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma. 2016 Sci Rep pmid:26911838
Wu G et al. Growth temperature and genotype both play important roles in sorghum grain phenolic composition. 2016 Sci Rep pmid:26907726
Bridgeman BB et al. Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention. 2016 Cell. Signal. pmid:26876613
Verma S et al. Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations. 2016 PLoS ONE pmid:26863418
Fonseca-Silva F et al. Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action. 2016 PLoS Negl Trop Dis pmid:26862901
Zhu Q et al. Antinociceptive effects of vitexin in a mouse model of postoperative pain. 2016 Sci Rep pmid:26763934
Wang W et al. Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor. 2016 PLoS ONE pmid:26730961
Lv H et al. Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways. 2016 Int. J. Biol. Sci. pmid:26722219
Cai M et al. Apigenin-7-O-β-D-(-6''-p-coumaroyl)-Glucopyranoside Treatment Elicits Neuroprotective Effect against Experimental Ischemic Stroke. 2016 Int. J. Biol. Sci. pmid:26722216
Tian X et al. Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C. 2016 Biol. Pharm. Bull. pmid:26581323
Asanagi M et al. Tributyltin induces G2/M cell cycle arrest via NAD(+)-dependent isocitrate dehydrogenase in human embryonic carcinoma cells. 2016 J Toxicol Sci pmid:26961604
Ginwala R et al. Apigenin, a Natural Flavonoid, Attenuates EAE Severity Through the Modulation of Dendritic Cell and Other Immune Cell Functions. 2016 J Neuroimmune Pharmacol pmid:26040501
Balez R et al. Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease. 2016 Sci Rep pmid:27514990
Zhu H et al. Apigenin induced apoptosis in esophageal carcinoma cells by destruction membrane structures. 2016 Scanning pmid:26435325
Pápay ZE et al. Development of oral site-specific pellets containing flavonoid extract with antioxidant activity. 2016 Eur J Pharm Sci pmid:27989856
Lin F et al. [Inhibitory effect of jianpi-jiedu prescription-contained serum on colorectal cancer SW48 cell proliferation by mTOR-P53-P21 signalling pathway]. 2016 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:27932756
Shu L et al. [Effects of apigenin on self-renewal and 
uPAR expression in NCI-H446 cell line]. 2016 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:27932755
Yagishita Y et al. Photochromic Properties of 3-Deoxyanthocyanidin Pigments in Nontoxic Solvents. 2016 J. Food Sci. pmid:27925261
Kandhare AD et al. Acute and repeated doses (28 days) oral toxicity study of Vicenin-1, a flavonoid glycoside isolated from fenugreek seeds in laboratory mice. 2016 Regul. Toxicol. Pharmacol. pmid:27773753
Song M et al. Apigenin protects mice from pneumococcal pneumonia by inhibiting the cytolytic activity of pneumolysin. 2016 Fitoterapia pmid:27693741
He M et al. A review on the pharmacological effects of vitexin and isovitexin. 2016 Fitoterapia pmid:27693342
Dai J et al. Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. 2016 Toxicol. Appl. Pharmacol. pmid:27664007
Mudge EM et al. Single-Laboratory Validation for the Determination of Flavonoids in Hawthorn Leaves and Finished Products by LC-UV. 2016 Planta Med. pmid:27776376
Whitehouse S et al. Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties. 2016 Phytomedicine pmid:27765370
Li Q et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. 2016 J Clin Neurosci pmid:27742373
Das MC et al. Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin. 2016 Sci Rep pmid:27000525
Zhao S et al. Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. 2016 Int. Immunopharmacol. pmid:27728897
Hakobyan A et al. Apigenin inhibits African swine fever virus infection in vitro. 2016 Arch. Virol. pmid:27638776
Coelho PL et al. The flavonoid apigenin from Croton betulaster Mull inhibits proliferation, induces differentiation and regulates the inflammatory profile of glioma cells. 2016 Anticancer Drugs pmid:27622606
Xiao L et al. A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP. 2016 Eur J Pharm Sci pmid:27586020
Zeng L et al. Inhibitory Mechanism of Apigenin on α-Glucosidase and Synergy Analysis of Flavonoids. 2016 J. Agric. Food Chem. pmid:27581205
Erdogan S et al. The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling. 2016 Life Sci. pmid:27569589
Mendel M et al. Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study. 2016 Animal pmid:27534882
Huang Y et al. Preparation of inclusion complex of apigenin-hydroxypropyl-β-cyclodextrin by using supercritical antisolvent process for dissolution and bioavailability enhancement. 2016 Int J Pharm pmid:27515291
Večeřová K et al. Changes of primary and secondary metabolites in barley plants exposed to CdO nanoparticles. 2016 Environ. Pollut. pmid:27503055
Shukla R et al. Fabrication of Apigenin loaded gellan gum-chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing. 2016 Int. J. Biol. Macromol. pmid:27344952
Wang Z et al. Inhibitory Effect of Apigenin on Losartan Metabolism and CYP2C9 Activity in vitro. 2016 Pharmacology pmid:27287328
Choi S et al. Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo. 2016 Int. J. Mol. Med. pmid:27279007
Hlila MB et al. Characterisation of phenolic antioxidants in Scabiosa arenaria flowers by LC-ESI-MS/MS and NMR. 2016 J. Pharm. Pharmacol. pmid:27230582
Terpinc P et al. LC-MS analysis of phenolic compounds and antioxidant activity of buckwheat at different stages of malting. 2016 Food Chem pmid:27211614
Kandhare AD et al. Development and validation of HPLC method for vicenin-1 isolated from fenugreek seeds in rat plasma: application to pharmacokinetic, tissue distribution and excretion studies. 2016 Pharm Biol pmid:27181500
Liu M et al. Rapid screening of transferrin-binders in the flowers of Bauhinia blakeana Dunn by on-line high-performance liquid chromatography-diode-array detector-electrospray ionization-ion-trap-time-of-flight-mass spectrometry-transferrin-fluorescence detection system. 2016 J Chromatogr A pmid:27178150
Karamese M et al. Anti-oxidant and anti-inflammatory effects of apigenin in a rat model of sepsis: an immunological, biochemical, and histopathological study. 2016 Immunopharmacol Immunotoxicol pmid:27144896
Huang C et al. Chrysin, Abundant in Morinda citrifolia Fruit Water-EtOAc Extracts, Combined with Apigenin Synergistically Induced Apoptosis and Inhibited Migration in Human Breast and Liver Cancer Cells. 2016 J. Agric. Food Chem. pmid:27137679
Cattaneo F et al. Flour from Prosopis alba cotyledons: A natural source of nutrient and bioactive phytochemicals. 2016 Food Chem pmid:27132827
Freitas JV and Gaspar LR In vitro photosafety and efficacy screening of apigenin, chrysin and beta-carotene for UVA and VIS protection. 2016 Eur J Pharm Sci pmid:27130544
Seydi E et al. Selective Toxicity of Apigenin on Cancerous Hepatocytes by Directly Targeting their Mitochondria. 2016 Anticancer Agents Med Chem pmid:27109019
Fang M et al. Scutellarin promotes microglia-mediated astrogliosis coupled with improved behavioral function in cerebral ischemia. 2016 Neurochem. Int. pmid:27105682
Wang X et al. Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer. 2016 Fitoterapia pmid:27102611
Dubois N et al. Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential. 2016 Int. J. Oncol. pmid:27098015
Simeonova R et al. Antidiabetic and antioxidant effects of saponarin from Gypsophila trichotoma on streptozotocin-induced diabetic normotensive and hypertensive rats. 2016 Phytomedicine pmid:27064007
Kim BK et al. Enhancing oral bioavailability using preparations of apigenin-loaded W/O/W emulsions: In vitro and in vivo evaluations. 2016 Food Chem pmid:27041302
Jiang Z et al. Determination of scutellarin in breviscapine preparations using quantitative proton nuclear magnetic resonance spectroscopy. 2016 J Food Drug Anal pmid:28911594
Han F et al. Application of alkyl polyglycoside surfactant in ultrasonic-assisted extraction followed by macroporous resin enrichment for the separation of vitexin-2″-O-rhamnoside and vitexin from Crataegus pinnatifida leaves. 2016 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:26807707
Ren B et al. Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats. 2016 Eur. J. Pharmacol. pmid:26801071
Dos Santos KC et al. Passiflora actinia hydroalcoholic extract and its major constituent, isovitexin, are neuroprotective against glutamate-induced cell damage in mice hippocampal slices. 2016 J. Pharm. Pharmacol. pmid:26800497
Luan RL et al. Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice. 2016 Inflammation pmid:26782361
Steuck M et al. Food Polyphenol Apigenin Inhibits the Cytochrome P450 Monoxygenase Branch of the Arachidonic Acid Cascade. 2016 J. Agric. Food Chem. pmid:27933871
Wang Z et al. Scutellarin protects cardiomyocyte ischemia-reperfusion injury by reducing apoptosis and oxidative stress. 2016 Life Sci. pmid:26775564
Ku SK and Bae JS Vicenin-2 and scolymoside inhibit high-glucose-induced vascular inflammation in vitro and in vivo. 2016 Can. J. Physiol. Pharmacol. pmid:26766560
Hou K et al. Ionic liquids-lithium salts pretreatment followed by ultrasound-assisted extraction of vitexin-4″-O-glucoside, vitexin-2″-O-rhamnoside and vitexin from Phyllostachys edulis leaves. 2016 J Chromatogr A pmid:26763300
Schmidt J Negative ion electrospray high-resolution tandem mass spectrometry of polyphenols. 2016 J Mass Spectrom pmid:26757070
Yang MH et al. A new flavone C-glycoside and a new bibenzyl from Bulbophyllum retusiusculum. 2016 Nat. Prod. Res. pmid:26729275
Nasr-Bouzaiene N et al. Immunomodulatory and cellular antioxidant activities of pure compounds from Teucrium ramosissimum Desf. 2016 Tumour Biol. pmid:26692099
Zhang S et al. Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice. 2016 Inflammation pmid:26658748
Fan J et al. Shear rheology and in-vitro release kinetic study of apigenin from lyotropic liquid crystal. 2016 Int J Pharm pmid:26657272
Nasr Bouzaiene N et al. Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. 2016 Life Sci. pmid:26656314
Romero GB et al. Simple low-cost miniaturization approach for pharmaceutical nanocrystals production. 2016 Int J Pharm pmid:26642945
Basios N et al. Apigenin Attenuates Inflammation in Experimentally Induced Acute Pancreatitis-Associated Lung Injury. 2016 J Invest Surg pmid:26631908
Lee IC and Bae JS Anti-inflammatory effects of vicenin-2 and scolymoside on polyphosphate-mediated vascular inflammatory responses. 2016 Inflamm. Res. pmid:26621502
Lou SN et al. Phenolic content, antioxidant activity and effective compounds of kumquat extracted by different solvents. 2016 Food Chem pmid:26616917
Guimarães R et al. Wild Roman chamomile extracts and phenolic compounds: enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase. 2016 Food Funct pmid:26446815
Li R et al. Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain. 2016 Behav. Brain Res. pmid:26416673
Pápay ZE et al. Comparative evaluation of the effect of cyclodextrins and pH on aqueous solubility of apigenin. 2016 J Pharm Biomed Anal pmid:26363816
Venditti A et al. Phytochemical analysis of Achillea ligustica All. from Lipari Island (Aeolian Islands). 2016 Nat. Prod. Res. pmid:26327332
Patil RH et al. Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells. 2016 Inflammation pmid:26276128
Cochran DB et al. Degradable poly(apigenin) polymer inhibits tumor cell adhesion to vascular endothelial cells. 2016 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:26251070
Zou H et al. Two new flavonoids from Selaginella uncinata. 2016 J Asian Nat Prod Res pmid:26238803
Kubínová R et al. Anticholinesterase, antioxidant activity and phytochemical investigation into aqueous extracts from five species of Agrimonia genus. 2016 Nat. Prod. Res. pmid:26235662
Iqbal MK et al. Recovery of Chicken Growth Plate by Heat-Shock Protein 90 Inhibitors Epigallocatechin-3-Gallate and Apigenin in Thiram-Induced Tibial Dyschondroplasia. 2016 Avian Dis. pmid:27902918