| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia | D007938 | 74 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Ventricular Dysfunction, Left | D018487 | 33 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gao Q et al. | The first total synthesis of 7-O-beta-D-glucopyranosyl-4'-O-alpha-L-rhamnopyranosyl apigenin via a hexanoyl ester-based protection strategy. | 2009 | Carbohydr. Res. | pmid:19187930 |
| Chen J et al. | The efficient total synthesis of bis-glycosyl apigenin from naringenin: a greener way. | 2009 | Carbohydr. Res. | pmid:19729151 |
| Simsek S et al. | An apigenin-induced decrease in K-antigen production by Sinorhizobium sp. NGR234 is y4gM- and nodD1-dependent. | 2009 | Carbohydr. Res. | pmid:19679303 |
| Nassar MI | Flavonoid triglycosides from the seeds of Syzygium aromaticum. | 2006 | Carbohydr. Res. | pmid:16297892 |
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| Fang J et al. | Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. | 2007 | Carcinogenesis | pmid:17071632 |
| Puppala D et al. | Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation. | 2007 | Carcinogenesis | pmid:17012224 |
| Hu XW et al. | Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase. | 2008 | Carcinogenesis | pmid:18974065 |
| Byun S et al. | Src kinase is a direct target of apigenin against UVB-induced skin inflammation. | 2013 | Carcinogenesis | pmid:23161610 |
| Lin FM et al. | Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells. | 2007 | Carcinogenesis | pmid:17942463 |
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| Gao AM et al. | Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway. | 2013 | Carcinogenesis | pmid:23563091 |
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