| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insulin Resistance | D007333 | 99 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sang SM et al. | [Studies on the flavonol glycosides from the seeds of Vaccaria segetalis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512436 |
| Zhang WD et al. | [Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516462 |
| Zhang J et al. | [Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516463 |
| Zanoli P et al. | Behavioral characterisation of the flavonoids apigenin and chrysin. | 2000 | Fitoterapia | pmid:10930722 |
| Trochon V et al. | Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression. | 2000 | Int. J. Cancer | pmid:10699950 |
| Nakazawa T and Ohsawa K | Metabolites of orally administered Perilla frutescens extract in rats and humans. | 2000 | Biol. Pharm. Bull. | pmid:10706426 |
| Hiremath SP et al. | Antifertility and hormonal properties of flavones of Striga orobanchioides. | 2000 | Eur. J. Pharmacol. | pmid:10720651 |
| Caltagirone S et al. | Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. | 2000 | Int. J. Cancer | pmid:10918203 |
| Romanová D et al. | Determination of apigenin in rat plasma by high-performance liquid chromatography. | 2000 | J Chromatogr A | pmid:10722103 |
| Pieroni A and Pachaly P | Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L. | 2000 | Pharmazie | pmid:10683879 |
| Ashida H | Suppressive effects of flavonoids on dioxin toxicity. | 2000 | Biofactors | pmid:11216487 |
| Tatsuta A et al. | Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. | 2000 | Clin. Exp. Metastasis | pmid:11827069 |
| Casagrande F and Darbon JM | Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. | 2001 | Biochem. Pharmacol. | pmid:11322924 |
| Abou-Zaid MM et al. | Acylated flavone C-glycosides from Cucumis sativus. | 2001 | Phytochemistry | pmid:11524127 |
| Haribal M and Renwick JA | Seasonal and population variation in flavonoid and alliarinoside content of Alliaria petiolata. | 2001 | J. Chem. Ecol. | pmid:11521398 |
| Oberdörster E et al. | Common phytochemicals are ecdysteroid agonists and antagonists: a possible evolutionary link between vertebrate and invertebrate steroid hormones. | 2001 | J. Steroid Biochem. Mol. Biol. | pmid:11457661 |
| Miean KH and Mohamed S | Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. | 2001 | J. Agric. Food Chem. | pmid:11410016 |
| Sun J et al. | [Investigation on method speliality in identifying Fructus Crataegi with vitexin rhamnoside]. | 2001 | Zhong Yao Cai | pmid:11917841 |
| Kitada C et al. | Differential expression of two cytochrome P450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of Perilla frutescens. | 2001 | Plant Cell Physiol. | pmid:11773526 |
| Begum AA et al. | Specific flavonoids induced nod gene expression and pre-activated nod genes of Rhizobium leguminosarum increased pea (Pisum sativum L.) and lentil (Lens culinaris L.) nodulation in controlled growth chamber environments. | 2001 | J. Exp. Bot. | pmid:11457914 |