| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ventricular Dysfunction, Left | D018487 | 33 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Cocaine-Related Disorders | D019970 | 3 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xie LP et al. | Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase. | 2003 | Biochemistry Mosc. | pmid:12765534 |
| Liu JQ et al. | [Studies on the chemical constituents from Chrysanthemum morifolium Ramat]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776368 |
| Martens S et al. | Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley. | 2003 | FEBS Lett. | pmid:12782296 |
| Kim K et al. | Galectin-3 expression in macrophages is signaled by Ras/MAP kinase pathway and up-regulated by modified lipoproteins. | 2003 | Biochim. Biophys. Acta | pmid:12788225 |
| Loetchutinat C et al. | Synthesis and evaluation of 5-Aryl-3-(4-hydroxyphenyl)-1,3,4-oxadiazole-2-(3H)-thiones as P-glycoprotein inhibitors. | 2003 | Chem. Pharm. Bull. | pmid:12808255 |
| Sikorska M et al. | Application of mass spectrometric techniques for structural analysis of apigenin 8-C-(6"-O-glucopyranosyl) glucopyranoside--a novel flavonoid C-diglycoside. | 2003 | Rapid Commun. Mass Spectrom. | pmid:12811762 |
| Sarno S et al. | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). | 2003 | Biochem. J. | pmid:12816539 |
| Miller CP et al. | Constrained phytoestrogens and analogues as ERbeta selective ligands. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12824043 |
| Naderi GA et al. | Anti-oxidant effect of flavonoids on the susceptibility of LDL oxidation. | 2003 | Mol. Cell. Biochem. | pmid:12841362 |
| Farah M et al. | 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12842827 |
| Oku H et al. | Antipruritic effects of the fruits of Chaenomeles sinensis. | 2003 | Biol. Pharm. Bull. | pmid:12843634 |
| Nazaruk J and Gudej J | Flavonoid compounds from the flowers of Cirsium rivulare (Jacq.) All. | 2003 Jan-Feb | Acta Pol Pharm | pmid:12848373 |
| Stroheker T et al. | Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats: a comparative study. | 2003 Jul-Aug | Reprod. Toxicol. | pmid:12849853 |
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| Materska M et al. | Isolation and structure elucidation of flavonoid and phenolic acid glycosides from pericarp of hot pepper fruit Capsicum annuum L. | 2003 | Phytochemistry | pmid:12895536 |
| Smolinski AT and Pestka JJ | Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew). | 2003 | Food Chem. Toxicol. | pmid:12909272 |
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| Schoefer L et al. | Anaerobic degradation of flavonoids by Clostridium orbiscindens. | 2003 | Appl. Environ. Microbiol. | pmid:14532034 |
| Basu NK et al. | Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. | 2004 | J. Biol. Chem. | pmid:14557274 |
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| Koo H et al. | Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. | 2003 | J. Antimicrob. Chemother. | pmid:14563892 |
| Scippo ML et al. | Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. | 2004 | Anal Bioanal Chem | pmid:14579009 |
| Zhong D et al. | Determination of scutellarin in rat plasma by high-performance liquid chromatography with ultraviolet detection. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14581083 |
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| Yingprasertchai S et al. | Hyaluronidase inhibitors (sodium cromoglycate and sodium auro-thiomalate) reduce the local tissue damage and prolong the survival time of mice injected with Naja kaouthia and Calloselasma rhodostoma venoms. | 2003 | Toxicon | pmid:14602119 |
| Way TD et al. | Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. | 2004 | J. Biol. Chem. | pmid:14602723 |
| Zhang JL et al. | Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR. | 2003 | J Asian Nat Prod Res | pmid:14604233 |
| Van Dross R et al. | The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines. | 2003 | J. Nutr. | pmid:14608117 |