| MeSH term | MeSH ID | Detail |
|---|---|---|
| Encephalitis | D004660 | 15 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Cocaine-Related Disorders | D019970 | 3 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li F et al. | Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy. | 2017 | Oxid Med Cell Longev | pmid:28828145 |
| Tan GF et al. | AgFNS overexpression increase apigenin and decrease anthocyanins in petioles of transgenic celery. | 2017 | Plant Sci. | pmid:28818381 |
| Wang M et al. | Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus. | 2017 | Molecules | pmid:28771188 |
| Wang J et al. | Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy. | 2017 | J Nanobiotechnology | pmid:28249594 |
| Souza RP et al. | Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines. | 2017 | Oxid Med Cell Longev | pmid:28191273 |
| Nelson N et al. | Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer. | 2017 | PLoS ONE | pmid:28152014 |
| Wang F et al. | Vitexin alleviates lipopolysaccharide‑induced islet cell injury by inhibiting HMGB1 release. | 2017 | Mol Med Rep | pmid:28098903 |
| Yao H et al. | DPPH·-luminol chemiluminescence system and its application in the determination of scutellarin in pharmaceutical injections and rat plasma with flow injection analysis. | 2017 | Luminescence | pmid:27860193 |
| Mokashi P et al. | Swertisin rich fraction from Enicostema littorale ameliorates hyperglycemia and hyperlipidemia in high-fat fed diet and low dose streptozotacin induced type 2 diabetes mellitus in rats. | 2017 | Biomed. Pharmacother. | pmid:29031588 |
| Choi WH et al. | Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. | 2017 | Mol Nutr Food Res | pmid:28971573 |
| Zhao T et al. | Novel apigenin-loaded sodium hyaluronate nano-assemblies for targeting tumor cells. | 2017 | Carbohydr Polym | pmid:28962787 |
| Han T et al. | Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation. | 2017 | Eur J Med Chem | pmid:28458133 |
| Adaszyńska-Skwirzyńska M and Dzięcioł M | Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. | 2017 | Nat. Prod. Res. | pmid:28449600 |
| Mohammad F E et al. | Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. | 2017 | J. Biochem. Mol. Toxicol. | pmid:28422384 |
| Feng X et al. | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Biochem. Pharmacol. | pmid:28414138 |
| Bai Y et al. | Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications. | 2017 | Appl. Biochem. Biotechnol. | pmid:27933483 |
| Sheeja Malar D et al. | Cholinesterase inhibitory, anti-amyloidogenic and neuroprotective effect of the medicinal plant Grewia tiliaefolia - An in vitro and in silico study. | 2017 | Pharm Biol | pmid:27931177 |
| Guzelmeric E et al. | Quality assessment of marketed chamomile tea products by a validated HPTLC method combined with multivariate analysis. | 2017 | J Pharm Biomed Anal | pmid:27693951 |
| Oliveira KG et al. | Effect of the storage time and temperature on phenolic compounds of sorghum grain and flour. | 2017 | Food Chem | pmid:27596435 |
| Das A et al. | Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28456117 |