| MeSH term | MeSH ID | Detail |
|---|---|---|
| Encephalitis | D004660 | 15 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Cocaine-Related Disorders | D019970 | 3 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Song DH et al. | Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. | 2000 | J. Biol. Chem. | pmid:10806215 |
| Bible KC et al. | Flavopiridol binds to duplex DNA. | 2000 | Cancer Res. | pmid:10811119 |
| Pieroni A et al. | Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae). | 2000 | J Ethnopharmacol | pmid:10837985 |
| Wang W et al. | Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines. | 2000 | Mol. Carcinog. | pmid:10900467 |
| Caltagirone S et al. | Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. | 2000 | Int. J. Cancer | pmid:10918203 |
| Yoshikawa M et al. | Medicinal foodstuffs. XVIII. Phytoestrogens from the aerial part of Petroselinum crispum MIll. (Parsley) and structures of 6"-acetylapiin and a new monoterpene glycoside, petroside. | 2000 | Chem. Pharm. Bull. | pmid:10923837 |
| Ecay TW et al. | Wortmannin inhibition of forskolin-stimulated chloride secretion by T84 cells. | 2000 | Biochim. Biophys. Acta | pmid:10930508 |
| Zanoli P et al. | Behavioral characterisation of the flavonoids apigenin and chrysin. | 2000 | Fitoterapia | pmid:10930722 |
| Breinholt V et al. | Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. | 2000 | Food Chem. Toxicol. | pmid:10942316 |
| Mucaji P et al. | [Apigenin-7-methylglucuronide from Cynara cardunculus L]. | 2000 | Ceska Slov Farm | pmid:10953447 |
| Uma Devi P et al. | Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. | 2000 | Radiat. Res. | pmid:11023610 |
| De Santi C et al. | Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. | 2000 | Xenobiotica | pmid:11055264 |
| Iwashita K et al. | Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11055382 |
| Illek B et al. | Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11078699 |
| Wang CN et al. | The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. | 2001 | J. Biol. Chem. | pmid:11083861 |
| Chen SB et al. | Aquiledine and isoaquiledine, novel flavonoid alkaloids from Aquilegia ecalcarata. | 2001 | J. Nat. Prod. | pmid:11170673 |
| Galati G et al. | Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation. | 2001 | Free Radic. Biol. Med. | pmid:11182292 |
| de Santi C et al. | Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. | 2000 | Xenobiotica | pmid:11197066 |
| Greenham J et al. | A distinctive flavonoid chemistry for the anomalous genus Biebersteinia. | 2001 | Phytochemistry | pmid:11198823 |
| Carini M et al. | LC coupled to ion-trap MS for the rapid screening and detection of polyphenol antioxidants from Helichrysum stoechas. | 2001 | J Pharm Biomed Anal | pmid:11199231 |