apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Encephalitis D004660 15 associated lipids
Weight Loss D015431 56 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Memory Disorders D008569 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Cocaine-Related Disorders D019970 3 associated lipids
Premature Birth D047928 6 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Genomic Instability D042822 7 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
Chromosomal Instability D043171 5 associated lipids
Lymphoma, Primary Effusion D054685 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Sang SM et al. [Studies on the flavonol glycosides from the seeds of Vaccaria segetalis]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12512436
Zhang WD et al. [Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12516462
Zhang J et al. [Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12516463
Trochon V et al. Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression. 2000 Int. J. Cancer pmid:10699950
Nakazawa T and Ohsawa K Metabolites of orally administered Perilla frutescens extract in rats and humans. 2000 Biol. Pharm. Bull. pmid:10706426
Hiremath SP et al. Antifertility and hormonal properties of flavones of Striga orobanchioides. 2000 Eur. J. Pharmacol. pmid:10720651
Romanová D et al. Determination of apigenin in rat plasma by high-performance liquid chromatography. 2000 J Chromatogr A pmid:10722103
Pieroni A and Pachaly P Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L. 2000 Pharmazie pmid:10683879
Breinholt V et al. Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. 2000 Food Chem. Toxicol. pmid:10942316
Ashida H Suppressive effects of flavonoids on dioxin toxicity. 2000 Biofactors pmid:11216487
Chan EC et al. Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. 2000 J. Cardiovasc. Pharmacol. pmid:10672869
Segaert S et al. The flavonoid apigenin suppresses vitamin D receptor expression and vitamin D responsiveness in normal human keratinocytes. 2000 Biochem. Biophys. Res. Commun. pmid:10652242
Griffith AP and Collison MW Improved methods for the extraction and analysis of isoflavones from soy-containing foods and nutritional supplements by reversed-phase high-performance liquid chromatography and liquid chromatography-mass spectrometry. 2001 J Chromatogr A pmid:11355838
Liu JQ et al. [Studies on the chemical constituents from Chrysanthemum morifolium Ramat]. 2001 Zhongguo Zhong Yao Za Zhi pmid:12776368
Aquino R et al. Phenolic constituents and antioxidant activity of an extract of Anthuriumversicolor leaves. 2001 J. Nat. Prod. pmid:11520218
Kyriakopoulou I et al. Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia. 2001 J. Nat. Prod. pmid:11520237
Martens S et al. Cloning of parsley flavone synthase I. 2001 Phytochemistry pmid:11524111
Landesman-Bollag E et al. Protein kinase CK2: signaling and tumorigenesis in the mammary gland. 2001 Mol. Cell. Biochem. pmid:11827167
Sun J et al. [Investigation on method speliality in identifying Fructus Crataegi with vitexin rhamnoside]. 2001 Zhong Yao Cai pmid:11917841
Qu J et al. Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry. 2001 J Chromatogr A pmid:11587333