| MeSH term | MeSH ID | Detail |
|---|---|---|
| Encephalitis | D004660 | 15 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Cocaine-Related Disorders | D019970 | 3 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gao HM et al. | [Pharmacokinetics and metabolites of scutellarin in normal and model rats]. | 2005 | Yao Xue Xue Bao | pmid:16499088 |
| He B et al. | [A new method of calibration and positioning in quantitative analysis of multicomponents by single marker]. | 2012 | Yao Xue Xue Bao | pmid:23460972 |
| Jiang XH et al. | [Study on the pharmacokinetics of scutellarin in dogs]. | 2003 | Yao Xue Xue Bao | pmid:12958843 |
| Li J and Chen YT | [Two flavonoids from Lagopsis supina]. | 2002 | Yao Xue Xue Bao | pmid:12579758 |
| Ren YL and Yang JS | [Study on chemical constituents of Hemistepta lyrata Bunge]. | 2001 | Yao Xue Xue Bao | pmid:12579973 |
| Lo WL et al. | [Pharmacokinetics of breviscapine liposomes following intravenous injection in Beagle dogs]. | 2006 | Yao Xue Xue Bao | pmid:16683523 |
| Feng WS et al. | Chemical constituents from the leaves of Broussonetia papyrifera. | 2008 | Yao Xue Xue Bao | pmid:18507345 |
| Tian Y et al. | [Apigenin glycosides from Euphorbia humifusa wild]. | 2009 | Yao Xue Xue Bao | pmid:19618725 |
| Chen ZN et al. | [Spectral analysis of clerodendrin, isolated from Clerodendron trichotomum Thunb]. | 1988 | Yao Xue Xue Bao | pmid:3257032 |
| Gong YJ et al. | [Intestinal lymphatic transport of breviscapine orally administered in rat]. | 2011 | Yao Xue Xue Bao | pmid:22242462 |
| Lin M and Li SZ | [Studies on the chemical constituents of Populus tomentosa carr]. | 1993 | Yao Xue Xue Bao | pmid:8249602 |
| Sun XY et al. | [Chemical constituents of Trichosanthes kirilowii Maxim]. | 2012 | Yao Xue Xue Bao | pmid:22993858 |
| Li LL and Chen XM | [Preparation and spectral characterization of apigenin molecularly imprinted polymer]. | 2009 | Yao Xue Xue Bao | pmid:20055154 |
| Fu XZ et al. | [Design, synthesis and anti-oxidative evaluation of L-amino acid prodrugs of scutellarein]. | 2011 | Yao Xue Xue Bao | pmid:21800542 |
| Luo P et al. | Scutellarin isolated from Erigeron multiradiatus inhibits high glucose-mediated vascular inflammation. | 2008 | Yakugaku Zasshi | pmid:18758143 |
| Yasukawa K et al. | [Studies on the constituents in the water extracts in crude drugs. IV. On the roots of Stellaria dichotoma L. var lanceolata Bge. (2(2)) (author's transl)]. | 1982 | Yakugaku Zasshi | pmid:7108760 |
| Zheng YN et al. | Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism. | 2005 | Yakugaku Zasshi | pmid:16327246 |
| Liang ZD et al. | [Effect of Apigenin on proliferation, cell cycle and apoptosis of mouse T cells in vitro]. | 2008 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:18394337 |
| Galijatovic A et al. | Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. | 1999 | Xenobiotica | pmid:10647910 |
| de Santi C et al. | Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. | 2000 | Xenobiotica | pmid:11197066 |