| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chan JY et al. | Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation. | 2009 | Anticancer Res. | pmid:19661313 |
| Cheong JW et al. | Inhibition of CK2{alpha} and PI3K/Akt synergistically induces apoptosis of CD34+CD38- leukaemia cells while sparing haematopoietic stem cells. | 2010 | Anticancer Res. | pmid:21115916 |
| Kim SH et al. | Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. | 2015 | Anticancer Res. | pmid:26637867 |
| Yin F et al. | Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. | 2001 Jan-Feb | Anticancer Res. | pmid:11299771 |
| Koo H et al. | Influence of apigenin on gtf gene expression in Streptococcus mutans UA159. | 2006 | Antimicrob. Agents Chemother. | pmid:16436708 |
| Wong IL et al. | Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania. | 2007 | Antimicrob. Agents Chemother. | pmid:17194831 |
| Bach A et al. | The antioxidant quercetin inhibits cellular proliferation via HIF-1-dependent induction of p21WAF. | 2010 | Antioxid. Redox Signal. | pmid:19958256 |
| Mahmood N et al. | Inhibition of HIV infection by flavanoids. | 1993 | Antiviral Res. | pmid:8279812 |
| Lv X et al. | Apigenin inhibits enterovirus 71 replication through suppressing viral IRES activity and modulating cellular JNK pathway. | 2014 | Antiviral Res. | pmid:24971492 |
| Nagai T et al. | In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase. | 1992 | Antiviral Res. | pmid:1444327 |
| Choi HJ et al. | Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus. | 2009 | Antiviral Res. | pmid:18992773 |
| Evers DL et al. | Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action. | 2005 | Antiviral Res. | pmid:16188329 |
| Shukla S et al. | Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer. | 2014 | Apoptosis | pmid:24563225 |
| Bhandari D et al. | Dual function surface-enhanced Raman active extractor for the detection of environmental contaminants. | 2009 | Appl Spectrosc | pmid:19470216 |
| Nisha VM et al. | Apigenin and quercetin ameliorate mitochondrial alterations by tunicamycin-induced ER stress in 3T3-L1 adipocytes. | 2014 | Appl. Biochem. Biotechnol. | pmid:25106896 |
| Bai Y et al. | Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications. | 2017 | Appl. Biochem. Biotechnol. | pmid:27933483 |
| Schoefer L et al. | Anaerobic degradation of flavonoids by Clostridium orbiscindens. | 2003 | Appl. Environ. Microbiol. | pmid:14532034 |
| Xia F et al. | Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus. | 2015 | Appl. Environ. Microbiol. | pmid:26475103 |
| Braune A and Blaut M | Intestinal bacterium Eubacterium cellulosolvens deglycosylates flavonoid C- and O-glucosides. | 2012 | Appl. Environ. Microbiol. | pmid:22961906 |
| Miyahisa I et al. | Combinatorial biosynthesis of flavones and flavonols in Escherichia coli. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16133333 |