| MeSH term | MeSH ID | Detail |
|---|---|---|
| Melanoma | D008545 | 69 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Viacava GE et al. | Characterization of phenolic compounds in green and red oak-leaf lettuce cultivars by UHPLC-DAD-ESI-QToF/MS using MS scan mode. | 2017 | J Mass Spectrom | pmid:28833875 |
| Li F et al. | Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy. | 2017 | Oxid Med Cell Longev | pmid:28828145 |
| Tan GF et al. | AgFNS overexpression increase apigenin and decrease anthocyanins in petioles of transgenic celery. | 2017 | Plant Sci. | pmid:28818381 |
| Souza RP et al. | Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines. | 2017 | Oxid Med Cell Longev | pmid:28191273 |
| Nelson N et al. | Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer. | 2017 | PLoS ONE | pmid:28152014 |
| Yao H et al. | DPPH·-luminol chemiluminescence system and its application in the determination of scutellarin in pharmaceutical injections and rat plasma with flow injection analysis. | 2017 | Luminescence | pmid:27860193 |
| Choi WH et al. | Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. | 2017 | Mol Nutr Food Res | pmid:28971573 |
| Adaszyńska-Skwirzyńska M and Dzięcioł M | Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. | 2017 | Nat. Prod. Res. | pmid:28449600 |
| Das A et al. | Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28456117 |
| Brunschwig C et al. | Chemical Composition and Antioxidant Activity of Euterpe oleracea Roots and Leaflets. | 2016 | Int J Mol Sci | pmid:28036089 |
| Schuster R et al. | Cajanus cajan- a source of PPARγ activators leading to anti-inflammatory and cytotoxic effects. | 2016 | Food Funct | pmid:27603115 |
| He JD et al. | Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway. | 2016 | Oncotarget | pmid:27588401 |
| Cai M et al. | Apigenin-7-O-β-D-(-6''-p-coumaroyl)-Glucopyranoside Treatment Elicits Neuroprotective Effect against Experimental Ischemic Stroke. | 2016 | Int. J. Biol. Sci. | pmid:26722216 |
| Yagishita Y et al. | Photochromic Properties of 3-Deoxyanthocyanidin Pigments in Nontoxic Solvents. | 2016 | J. Food Sci. | pmid:27925261 |
| Xiao L et al. | A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP. | 2016 | Eur J Pharm Sci | pmid:27586020 |
| Fang M et al. | Scutellarin promotes microglia-mediated astrogliosis coupled with improved behavioral function in cerebral ischemia. | 2016 | Neurochem. Int. | pmid:27105682 |
| Wang X et al. | Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer. | 2016 | Fitoterapia | pmid:27102611 |
| Fan J et al. | Shear rheology and in-vitro release kinetic study of apigenin from lyotropic liquid crystal. | 2016 | Int J Pharm | pmid:26657272 |
| Nasr Bouzaiene N et al. | Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. | 2016 | Life Sci. | pmid:26656314 |
| Romero GB et al. | Simple low-cost miniaturization approach for pharmaceutical nanocrystals production. | 2016 | Int J Pharm | pmid:26642945 |