| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jiang J et al. | Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR/Ulk1 pathway. | 2018 | Biomed. Pharmacother. | pmid:29710456 |
| Pei Y et al. | Combined effect of apigenin and ferulic acid on frozen-thawed boar sperm quality. | 2018 | Anim. Sci. J. | pmid:29708294 |
| Feng Y et al. | Apigenin-7-O-β-d-(-6″-p-coumaroyl)-glucopyranoside pretreatment attenuates myocardial ischemia/reperfusion injury via activating AMPK signaling. | 2018 | Life Sci. | pmid:29705352 |
| Malar DS et al. | Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro-2a cells from glutamate toxicity. | 2018 | Life Sci. | pmid:29704481 |
| Hadrich F and Sayadi S | Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPARγ and CEBP-α. | 2018 | Lipids Health Dis | pmid:29695233 |
| Lu Y et al. | Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway. | 2018 | PLoS ONE | pmid:29694408 |
| Dang Y et al. | Protective Effect of Apigenin on Acrylonitrile-Induced Inflammation and Apoptosis in Testicular Cells via the NF-κB Pathway in Rats. | 2018 | Inflammation | pmid:29687413 |
| You P et al. | Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-κB and p38/JNK pathway in LPS-induced BV-2 microglial cells. | 2018 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:29680917 |
| Yang J et al. | Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells. | 2018 | Biomed. Pharmacother. | pmid:29680738 |
| Gurunathan S et al. | Antibacterial Efficacy of Silver Nanoparticles on Endometritis Caused by and in Dairy Cattle. | 2018 | Int J Mol Sci | pmid:29659523 |
| Karamać M et al. | Phenolic contents and antioxidant capacities of wild and cultivated white lupin (Lupinus albus L.) seeds. | 2018 | Food Chem | pmid:29655709 |
| Mo J et al. | Scutellarin protects against vascular endothelial dysfunction and prevents atherosclerosis via antioxidation. | 2018 | Phytomedicine | pmid:29655699 |
| Kumar KS et al. | Isolation, identification and characterization of apigenin from Justicia gendarussa and its anti-inflammatory activity. | 2018 | Int. Immunopharmacol. | pmid:29655057 |
| Paredes MD et al. | Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. | 2018 | Nutrients | pmid:29652818 |
| Zeng YQ et al. | Scutellarin Mitigates Aβ-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice. | 2018 | Molecules | pmid:29642616 |
| Gentile D et al. | The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. | 2018 | PLoS ONE | pmid:29641549 |
| Kalogiouri NP et al. | Application of an advanced and wide scope non-target screening workflow with LC-ESI-QTOF-MS and chemometrics for the classification of the Greek olive oil varieties. | 2018 | Food Chem | pmid:29606472 |
| Hu WJ et al. | Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling. | 2018 | Biomed. Pharmacother. | pmid:29604587 |
| Hu JJ et al. | Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation. | 2018 | Microb. Pathog. | pmid:29604422 |
| Hu M et al. | Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway. | 2018 | Drug Des Devel Ther | pmid:29588573 |