| MeSH term | MeSH ID | Detail |
|---|---|---|
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brauch D et al. | Changes in isovitexin-O-glycosylation during the development of young barley plants. | 2018 | Phytochemistry | pmid:29421507 |
| Sun Q et al. | Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29408335 |
| Ling T et al. | Novel vitexin-inspired scaffold against leukemia. | 2018 | Eur J Med Chem | pmid:29407975 |
| Ashokkumar R et al. | Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29406244 |
| Liu X et al. | Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches. | 2018 | Nat Commun | pmid:29386648 |
| Oliveira DR et al. | Flavones-bound in benzodiazepine site on GABA receptor: Concomitant anxiolytic-like and cognitive-enhancing effects produced by Isovitexin and 6-C-glycoside-Diosmetin. | 2018 | Eur. J. Pharmacol. | pmid:29738701 |
| Dang Y et al. | Protective Effect of Apigenin on Acrylonitrile-Induced Inflammation and Apoptosis in Testicular Cells via the NF-κB Pathway in Rats. | 2018 | Inflammation | pmid:29687413 |
| You P et al. | Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-κB and p38/JNK pathway in LPS-induced BV-2 microglial cells. | 2018 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:29680917 |
| Yang J et al. | Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells. | 2018 | Biomed. Pharmacother. | pmid:29680738 |
| Hu JJ et al. | Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation. | 2018 | Microb. Pathog. | pmid:29604422 |
| Vrhovac Madunić I et al. | Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells. | 2018 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:29541820 |
| Zhang X et al. | Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway. | 2018 | Free Radic. Res. | pmid:29400110 |
| Kim A and Lee CS | Apigenin reduces the Toll-like receptor-4-dependent activation of NF-κB by suppressing the Akt, mTOR, JNK, and p38-MAPK. | 2018 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:29264665 |
| Radulovic K et al. | A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation. | 2018 | Mucosal Immunol | pmid:29139477 |
| Nabavi SF et al. | Apigenin as neuroprotective agent: Of mice and men. | 2018 | Pharmacol. Res. | pmid:29055745 |
| Abu Bakar AR et al. | Experimental and computational approaches to reveal the potential of Ficus deltoidea leaves extract as α-amylase inhibitor. | 2018 | Nat. Prod. Res. | pmid:28391727 |
| Ren K et al. | Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing Inflammation. | 2018 | Cell. Physiol. Biochem. | pmid:29975943 |
| Xia Y et al. | Apigenin Suppresses the IL-1β-Induced Expression of the Urokinase-Type Plasminogen Activator Receptor by Inhibiting MAPK-Mediated AP-1 and NF-κB Signaling in Human Bladder Cancer T24 Cells. | 2018 | J. Agric. Food Chem. | pmid:29945448 |
| Wang J et al. | Scutellarin enhances osteoblast proliferation and function via NF-κB-mediated CXCR4 induction. | 2018 | Gene | pmid:29936266 |
| Wong TY et al. | Traversal of the Blood-Brain Barrier by Cleavable l-Lysine Conjugates of Apigenin. | 2018 | J. Agric. Food Chem. | pmid:29923397 |
| Šarić Mustapić D et al. | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. | 2018 | Molecules | pmid:30301254 |
| Ravisankar S et al. | Structural profile of soluble and bound phenolic compounds in teff (Eragrostis tef) reveals abundance of distinctly different flavones in white and brown varieties. | 2018 | Food Chem | pmid:29784316 |
| Alzoman NZ et al. | CE-DAD Determination of Scutellarein and Caffeic Acid in Abelia triflora Crude Extract. | 2018 | J Chromatogr Sci | pmid:29750262 |
| Witkowska-Banaszczak E | Flavonoids from Trollius europaeus flowers and evaluation of their biological activity. | 2018 | J. Pharm. Pharmacol. | pmid:29466602 |
| Chledzik S et al. | Pharmacological Effects of Scutellarin, An Active Component of Genus Scutellaria and Erigeron: A Systematic Review. | 2018 | Am. J. Chin. Med. | pmid:29433387 |
| Zhu Q et al. | Comparison of flavonoids and isoflavonoids to inhibit rat and human 11β-hydroxysteroid dehydrogenase 1 and 2. | 2018 | Steroids | pmid:29425740 |
| Tao Y et al. | Pharmacokinetic comparisons of six components from raw and vinegar-processed Daphne genkwa aqueous extracts following oral administration in rats by employing UHPLC-MS/MS approaches. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29428673 |
| Srivastava A et al. | Swertisin ameliorates diabetes by triggering pancreatic progenitors for islet neogenesis in Streptozotocin treated BALB/c mice. | 2018 | Biomed. Pharmacother. | pmid:29428671 |
| Melguizo-RodrÃguez L et al. | Effect of olive oil phenolic compounds on osteoblast differentiation. | 2018 | Eur. J. Clin. Invest. | pmid:29392706 |
| Ni G et al. | Synthesis of Scutellarein Derivatives with a Long Aliphatic Chain and Their Biological Evaluation against Human Cancer Cells. | 2018 | Molecules | pmid:29389889 |
| Rimal H et al. | Hydroxylation of Resveratrol with DoxA In Vitro: An Enzyme with the Potential for the Bioconversion of a Bioactive Stilbene. | 2018 | J. Microbiol. Biotechnol. | pmid:29385664 |
| Zhang G et al. | Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells. | 2018 | Mol Med Rep | pmid:29328424 |
| Madunić J et al. | Apigenin: A dietary flavonoid with diverse anticancer properties. | 2018 | Cancer Lett. | pmid:29097249 |
| Zhong Y et al. | Scaffold Hopping Strategy for the Design, Synthesis and Biological Activity Evaluation of Novel Hexacyclic Scutellarein Derivatives with a 1,3-Oxazine Ring Fused at A-ring. | 2018 | Med Chem | pmid:28875860 |
| Renda G et al. | Evaluation of in vivo analgesic activity of Scrophularia kotscyhana and isolation of bioactive compounds through activity-guided fractionation. | 2018 | Nat. Prod. Res. | pmid:28758426 |
| Gaspar MC et al. | Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract. | 2018 | Nat. Prod. Res. | pmid:28627294 |
| Zengin G et al. | Multiple pharmacological approaches on Fibigia eriocarpa extracts by in vitro and computational assays. | 2018 | Fundam Clin Pharmacol | pmid:29505673 |
| Xin Z et al. | UPLC-Orbitrap-MS/MS combined with chemometrics establishes variations in chemical components in green tea from Yunnan and Hunan origins. | 2018 | Food Chem | pmid:30381222 |
| Mendel M et al. | Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study. | 2018 | J. Vet. Pharmacol. Ther. | pmid:28913883 |
| Cornara L et al. | Zornia latifolia: a smart drug being adulterated by Stylosanthes guianensis. | 2018 | Int. J. Legal Med. | pmid:29362872 |
| Cheruvu HS et al. | LC-MS/MS method for the simultaneous quantification of luteolin, wedelolactone and apigenin in mice plasma using hansen solubility parameters for liquid-liquid extraction: Application to pharmacokinetics of Eclipta alba chloroform fraction. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29518720 |
| Xu L et al. | Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects. | 2018 | J. Exp. Clin. Cancer Res. | pmid:30373602 |
| Vieira FN et al. | Long-Term Effect on Bioactive Components and Antioxidant Activity of Thermal and High-Pressure Pasteurization of Orange Juice. | 2018 | Molecules | pmid:30347848 |
| Wang X et al. | Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro. | 2018 | Ren Fail | pmid:30278824 |
| Han T et al. | Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. | 2018 | Eur J Med Chem | pmid:30243153 |
| Ojo OA et al. | Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. | 2018 | J Basic Clin Physiol Pharmacol | pmid:29381472 |
| Thangaiyan R et al. | Preventive effect of apigenin against isoproterenol-induced apoptosis in cardiomyoblasts. | 2018 | J. Biochem. Mol. Toxicol. | pmid:30152906 |
| Shin JW et al. | Scutellarin Ameliorates Learning and Memory Deficit via Suppressing [Formula: see text]-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion. | 2018 | Am. J. Chin. Med. | pmid:30149759 |
| Kim HJ et al. | Spirodela polyrhiza and its Chemical Constituent Vitexin Exert Anti-Allergic Effect via ORAI1 Channel Inhibition. | 2018 | Am. J. Chin. Med. | pmid:30149756 |
| Feng X et al. | Characterization of the In Vivo and In Vitro Metabolites of Linarin in Rat Biosamples and Intestinal Flora Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. | 2018 | Molecules | pmid:30149616 |