| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asthma | D001249 | 52 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Ventricular Dysfunction, Left | D018487 | 33 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Myhrstad MC et al. | Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. | 2002 | Free Radic. Biol. Med. | pmid:11864778 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Afaq F et al. | Botanical antioxidants for chemoprevention of photocarcinogenesis. | 2002 | Front. Biosci. | pmid:11897547 |
| Liu Y and Hu M | Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. | 2002 | Drug Metab. Dispos. | pmid:11901089 |
| Sun J et al. | [Investigation on method speliality in identifying Fructus Crataegi with vitexin rhamnoside]. | 2001 | Zhong Yao Cai | pmid:11917841 |
| Zhang YH et al. | Endothelium-dependent vasorelaxant and antiproliferative effects of apigenin. | 2000 | Gen. Pharmacol. | pmid:11922965 |
| Salah AM et al. | Estrogenic and cholinergic properties of the methanol extract of Ruellia praetermissa Sceinf. ex. Lindau (Acanthaceae) in female rats. | 2002 | Phytomedicine | pmid:11924764 |
| Kim MK et al. | Relationships of urinary phyto-oestrogen excretion to BMD in postmenopausal women. | 2002 | Clin. Endocrinol. (Oxf) | pmid:11940043 |
| Vanhoenacker G et al. | Chemotaxonomic features associated with flavonoids of cannabinoid-free cannabis (Cannabis sativa subsp. sativa L.) in relation to hops (Humulus lupulus L.). | 2002 | Nat Prod Lett | pmid:11942684 |
| Ohno S et al. | Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells. | 2002 | J. Steroid Biochem. Mol. Biol. | pmid:11948020 |
| Walle UK and Walle T | Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements. | 2002 | Drug Metab. Dispos. | pmid:11950788 |
| Breinholt VM et al. | In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. | 2002 | Food Chem. Toxicol. | pmid:11955666 |
| Lin CM et al. | Prevention of cellular ROS damage by isovitexin and related flavonoids. | 2002 | Planta Med. | pmid:11988866 |
| Kim HR et al. | Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A2. | 2001 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11993721 |
| Rager I et al. | Rapid quantification of constituents in St. John's wort extracts by NIR spectroscopy. | 2002 | J Pharm Biomed Anal | pmid:12008122 |
| Zhu CC et al. | Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. | 2002 | J. Biol. Chem. | pmid:12023974 |
| Usia T et al. | Constituents of Chinese propolis and their antiproliferative activities. | 2002 | J. Nat. Prod. | pmid:12027739 |
| Gupta S et al. | Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells. | 2002 | Oncogene | pmid:12032841 |
| Bito T et al. | Flavonoids differentially regulate IFN gamma-induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action. | 2002 | FEBS Lett. | pmid:12044887 |
| Zou L et al. | Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. | 2002 | Phytomedicine | pmid:12046870 |
| Lin CM et al. | Molecular modeling of flavonoids that inhibits xanthine oxidase. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054758 |
| Ross JA and Kasum CM | Dietary flavonoids: bioavailability, metabolic effects, and safety. | 2002 | Annu. Rev. Nutr. | pmid:12055336 |
| Rawel HM et al. | Interactions of different phenolic acids and flavonoids with soy proteins. | 2002 | Int. J. Biol. Macromol. | pmid:12063116 |
| Tsai SC and Seto E | Regulation of histone deacetylase 2 by protein kinase CK2. | 2002 | J. Biol. Chem. | pmid:12082111 |
| Brantner AH et al. | HET-CAM bioassay as in vitro alternative to the croton oil test for investigating steroidal and non-steroidal compounds. | 2002 | ALTEX | pmid:12098009 |
| Takahama U et al. | Oxidation of quercetin by salivary components. Quercetin-dependent reduction of salivary nitrite under acidic conditions producing nitric oxide. | 2002 | J. Agric. Food Chem. | pmid:12105964 |
| Prescott AG et al. | In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana. | 2002 | Phytochemistry | pmid:12126705 |
| Grayer RJ et al. | Scutellarein 4'-methyl ether glycosides as taxonomic markers in Teucridium and Tripora (Lamiaceae, Ajugoideae). | 2002 | Phytochemistry | pmid:12127590 |
| Nagao T et al. | Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. | 2002 | Biol. Pharm. Bull. | pmid:12132661 |
| Lee S et al. | Phytochemical constituents from the herba of Artemisia apiacea. | 2002 | Arch. Pharm. Res. | pmid:12135098 |
| Kim TJ et al. | Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells. | 2002 | Planta Med. | pmid:12142993 |
| Channavajhala P and Seldin DC | Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis. | 2002 | Oncogene | pmid:12149649 |
| Mastuda H et al. | Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells. | 2002 | Bioorg. Med. Chem. | pmid:12150856 |
| Ma T et al. | High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. | 2002 | J. Biol. Chem. | pmid:12161441 |
| Marder M and Paladini AC | GABA(A)-receptor ligands of flavonoid structure. | 2002 | Curr Top Med Chem | pmid:12171576 |
| Gil-Izquierdo A et al. | Effect of processing techniques at industrial scale on orange juice antioxidant and beneficial health compounds. | 2002 | J. Agric. Food Chem. | pmid:12188615 |
| Exarchou V et al. | Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory. | 2002 | J. Agric. Food Chem. | pmid:12207464 |
| Droillard M et al. | Different protein kinase families are activated by osmotic stresses in Arabidopsis thaliana cell suspensions. Involvement of the MAP kinases AtMPK3 and AtMPK6. | 2002 | FEBS Lett. | pmid:12220631 |
| Han DH et al. | Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224631 |
| Matławska I and Sikorska M | Flavonoid compounds in the flowers of Abutilon indicum (L.) Sweet (Malvaceae). | 2002 May-Jun | Acta Pol Pharm | pmid:12230251 |
| Cohen MF et al. | Synergistic effect of deoxyanthocyanins from symbiotic fern Azolla spp. on hrmA gene induction in the cyanobacterium Nostoc punctiforme. | 2002 | Mol. Plant Microbe Interact. | pmid:12236594 |
| Aboutabl EA et al. | Phytochemical and pharmacological studies on Sideritis taurica Stephan ex Wild. | 2002 | J Ethnopharmacol | pmid:12241993 |
| Zétola M et al. | CNS activities of liquid and spray-dried extracts from Lippia alba-Verbenaceae (Brazilian false melissa). | 2002 | J Ethnopharmacol | pmid:12241997 |
| Chen S et al. | [Studies on flavonoids from Aquilegia oxysepala Trautv. et Mey]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12242797 |
| Cao Y et al. | Analysis of flavonoids in Ginkgo biloba L. and its phytopharmaceuticals by capillary electrophoresis with electrochemical detection. | 2002 | Anal Bioanal Chem | pmid:12324852 |
| Miro FA et al. | Persistent nuclear accumulation of protein kinase CK2 during the G1-phase of the cell cycle does not depend on the ERK1/2 pathway but requires active protein synthesis. | 2002 | Arch. Biochem. Biophys. | pmid:12361704 |
| Patora J and Klimek B | Flavonoids from lemon balm (Melissa officinalis L., Lamiaceae). | 2002 Mar-Apr | Acta Pol Pharm | pmid:12365606 |
| Sampson L et al. | Flavonol and flavone intakes in US health professionals. | 2002 | J Am Diet Assoc | pmid:12396158 |
| Engelmann C et al. | Apigenin--strong cytostatic and anti-angiogenic action in vitro contrasted by lack of efficacy in vivo. | 2002 | Phytomedicine | pmid:12403156 |
| Agati G et al. | Flavonoid distribution in tissues of Phillyrea latifolia L. leaves as estimated by microspectrofluorometry and multispectral fluorescence microimaging. | 2002 | Photochem. Photobiol. | pmid:12403458 |
| Modolo LV et al. | Nitric oxide synthase-mediated phytoalexin accumulation in soybean cotyledons in response to the Diaporthe phaseolorum f. sp. meridionalis elicitor. | 2002 | Plant Physiol. | pmid:12427995 |
| Couladis M et al. | Antioxidant activity of polyphenols from Hypericum triquetrifolium Turra. | 2002 | Phytother Res | pmid:12458485 |
| Gradolatto A et al. | Could apigenin metabolism explain the estrogenic effect of this flavonoid in the female immature rat? | 2002 | IARC Sci. Publ. | pmid:12484224 |
| Koo H et al. | Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. | 2002 | Oral Microbiol. Immunol. | pmid:12485324 |
| Leslie EM et al. | Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). | 2003 | Drug Metab. Dispos. | pmid:12485947 |
| Snyder RD and Gillies PJ | Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells. | 2002 | Environ. Mol. Mutagen. | pmid:12489117 |
| Wang H et al. | Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex. | 2002 | Planta Med. | pmid:12494329 |
| Xing Y et al. | [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation]. | 2002 | Zhonghua Yi Xue Za Zhi | pmid:12509912 |
| Sang SM et al. | [Studies on the flavonol glycosides from the seeds of Vaccaria segetalis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512436 |
| Olszanecki R et al. | Flavonoids and nitric oxide synthase. | 2002 | J. Physiol. Pharmacol. | pmid:12512693 |
| Zhang WD et al. | [Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516462 |
| Zhang J et al. | [Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516463 |
| Morimoto M et al. | Insect antifeedant activity of flavones and chromones against Spodoptera litura. | 2003 | J. Agric. Food Chem. | pmid:12517100 |
| Sánchez-Rabaneda F et al. | Liquid chromatographic/electrospray ionization tandem mass spectrometric study of the phenolic composition of cocoa (Theobroma cacao). | 2003 | J Mass Spectrom | pmid:12526004 |
| Wang M et al. | Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). | 2003 | J. Agric. Food Chem. | pmid:12537429 |
| Fan CQ and Yue JM | Biologically active phenols from Saussurea medusa. | 2003 | Bioorg. Med. Chem. | pmid:12537999 |
| Li J and Chen YT | [Two flavonoids from Lagopsis supina]. | 2002 | Yao Xue Xue Bao | pmid:12579758 |
| Ren YL and Yang JS | [Study on chemical constituents of Hemistepta lyrata Bunge]. | 2001 | Yao Xue Xue Bao | pmid:12579973 |
| Goutman JD et al. | Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. | 2003 | Eur. J. Pharmacol. | pmid:12586201 |
| Huet M | Factors affecting the molecular structure and the agglutinating ability of concanavalin A and other lectins. | 1975 | Eur. J. Biochem. | pmid:1259 |
| Basile A et al. | Effects of seven pure flavonoids from mosses on germination and growth of Tortula muralis HEDW (Bryophyta) and Raphanus sativus L (Magnoliophyta). | 2003 | Phytochemistry | pmid:12591270 |
| Liu H et al. | [Study on effects of scutellarin on scavenging reactive oxygen]. | 2002 | Zhong Yao Cai | pmid:12599762 |
| Chen J et al. | Metabolism of flavonoids via enteric recycling: role of intestinal disposition. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12604700 |
| Sasaki N et al. | Protective effects of flavonoids on the cytotoxicity of linoleic acid hydroperoxide toward rat pheochromocytoma PC12 cells. | 2003 | Chem. Biol. Interact. | pmid:12606158 |
| Rojas S et al. | Calmodulin inhibitors from Leucophyllum ambiguum. | 2003 | J. Nat. Prod. | pmid:12608853 |
| Mead JR et al. | Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription. | 2003 | J. Biol. Chem. | pmid:12609974 |
| Whitehead SA and Lacey M | Phytoestrogens inhibit aromatase but not 17beta-hydroxysteroid dehydrogenase (HSD) type 1 in human granulosa-luteal cells: evidence for FSH induction of 17beta-HSD. | 2003 | Hum. Reprod. | pmid:12615812 |
| McPhail DB et al. | Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. | 2003 | J. Agric. Food Chem. | pmid:12617605 |
| Suominen L et al. | Activation of the nodA promoter by the nodD genes of Rhizobium galegae induced by synthetic flavonoids or Galega orientalis root exudate. | 2003 | FEMS Microbiol. Lett. | pmid:12620625 |
| Kavvadias D et al. | Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. | 2003 | Planta Med. | pmid:12624814 |
| Ahlenstiel T et al. | Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions. | 2003 | Kidney Int. | pmid:12631120 |
| Yee SB et al. | Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells. | 2003 | Arch. Pharm. Res. | pmid:12643593 |
| Orska-GawryÅ› J et al. | Identification of natural dyes in archeological Coptic textiles by liquid chromatography with diode array detection. | 2003 | J Chromatogr A | pmid:12650256 |
| Caci E et al. | CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12651632 |
| Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
| Owen RW et al. | Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes. | 2003 | Food Chem. Toxicol. | pmid:12659724 |
| Matsuda H et al. | Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action. | 2003 | Bioorg. Med. Chem. | pmid:12670650 |
| Nakazawa T et al. | Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test. | 2003 | Biol. Pharm. Bull. | pmid:12673028 |
| Oliveira RR et al. | High-speed countercurrent chromatography as a valuable tool to isolate C-glycosylflavones from Cecropia lyratiloba Miquel. | 2003 Mar-Apr | Phytochem Anal | pmid:12693634 |
| Greenham J et al. | Identification of lipophilic flavones and flavonols by comparative HPLC, TLC and UV spectral analysis. | Phytochem Anal | pmid:12693635 | |
| Boué SM et al. | Identification of flavone aglycones and glycosides in soybean pods by liquid chromatography-tandem mass spectrometry. | 2003 | J Chromatogr A | pmid:12703901 |
| Zhu F et al. | [Effect of emodin and apigenin on invasion of human ovarian carcinoma HO-8910PM cells in vitro]. | 2003 | Ai Zheng | pmid:12703988 |
| Ogawa M et al. | Nuclear translocation of Xenopus laevis paxillin. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12727207 |
| Sadhu SK et al. | Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant activities. | 2003 | Chem. Pharm. Bull. | pmid:12736464 |
| Lin YT et al. | Degradation of flavonoid aglycones by rabbit, rat and human fecal flora. | 2003 | Biol. Pharm. Bull. | pmid:12736527 |
| Agrelli J et al. | Herbivore-induced responses in alfalfa (Medicago sativa). | 2003 | J. Chem. Ecol. | pmid:12737260 |
| Hessenauer A et al. | Inhibition of CK2 activity provokes different responses in hormone-sensitive and hormone-refractory prostate cancer cells. | 2003 | Int. J. Oncol. | pmid:12738992 |
| Kim MH | Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases. | 2003 | J. Cell. Biochem. | pmid:12761886 |
| Hou CC et al. | Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica. | 2003 | J. Nat. Prod. | pmid:12762795 |
| Konstantinopoulou M et al. | Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity. | 2003 | J. Nat. Prod. | pmid:12762812 |