apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Asthma D001249 52 associated lipids
Thrombosis D013927 49 associated lipids
Precancerous Conditions D011230 48 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Memory Disorders D008569 33 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Kowalczyk A et al. Insights into novel anticancer applications for apigenin. 2017 Adv Clin Exp Med pmid:29211364
Pate KM et al. Anthoxanthin Polyphenols Attenuate Aβ Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease. 2017 CNS Neurosci Ther pmid:27864869
Ghazanfar K et al. Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. 2017 J Complement Integr Med pmid:28731312
Sun Y et al. Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. 2017 Molecules pmid:28696360
Seo HS et al. Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. 2017 Oncol. Rep. pmid:28656316
Spilovska K et al. Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. 2017 Molecules pmid:28621747
Salmani JMM et al. Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives. 2017 Chin J Nat Med pmid:28558867
Elmasri WA et al. Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization. 2017 J. Proteome Res. pmid:28541047
Yang PM et al. Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. 2017 Oncotarget pmid:28526810
Zhong Y et al. Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. 2017 Toxicon pmid:28734981
Elhennawy MG and Lin HS Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. 2017 J Pharm Biomed Anal pmid:28494337
Alvin JW and Lacy DB Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. 2017 J. Struct. Biol. pmid:28433497
Min JW et al. Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. 2017 Oncotarget pmid:28424420
Perrott KM et al. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. 2017 Geroscience pmid:28378188
Stump TA et al. The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. 2017 J. Pharm. Pharmacol. pmid:28349530
Sun XP et al. Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. 2017 Arch. Pharm. Res. pmid:28315259
Anusha C et al. Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. 2017 Chem. Biol. Interact. pmid:28389404
Naik PM and Al-Khayri JM Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. 2017 Methods Mol. Biol. pmid:28755356
Grigalius I and Petrikaite V Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. 2017 Molecules pmid:29215574
Granato M et al. Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. 2017 J. Exp. Clin. Cancer Res. pmid:29179721
Liao M et al. Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29127056
Medhat AM et al. Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. 2017 Tumour Biol. pmid:29022496
Ganesan K and Xu B Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. 2017 Ann. N. Y. Acad. Sci. pmid:28891090
Zhou RJ et al. Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. 2017 Biochem. Biophys. Res. Commun. pmid:28867192
Shan S et al. Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. 2017 J. Agric. Food Chem. pmid:28829588
Britto SM et al. Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. 2017 Mutat. Res. pmid:28735741
Wen L et al. An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. 2017 Molecules pmid:28486427
Jangdey MS et al. Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. 2017 Drug Deliv pmid:28687053
Lee JA et al. Effects of friedelin on the intestinal permeability and bioavailability of apigenin. 2017 Pharmacol Rep pmid:28939344
Tamayose CI et al. Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. 2017 Int J Mol Sci pmid:28906474
Zhang L et al. Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. 2017 Mol Med Rep pmid:28849116
Tu F et al. Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. 2017 Med. Sci. Monit. pmid:28821706
Liu S and Ho PC Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. 2017 J. Pharm. Pharmacol. pmid:28809432
Fallatah O and Georges E Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. 2017 Int. J. Antimicrob. Agents pmid:28807879
Che Ahmad Tantowi NA et al. Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. 2017 Menopause pmid:28640163
Li J et al. Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. 2017 World J. Gastroenterol. pmid:28611514
Wu W et al. Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. 2017 Drug Dev Ind Pharm pmid:28402147
Chen JL and Ko WC Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. 2017 Eur. J. Pharmacol. pmid:28603044
Wan Y et al. miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. 2017 Tumour Biol. pmid:28381178
Singhal SS et al. Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. 2017 Biochim Biophys Acta Rev Cancer pmid:28359741
Zhang Z et al. Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. 2017 Drug Dev Ind Pharm pmid:28358225
Han Y et al. Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. 2017 J Clin Neurosci pmid:28342702
Bian M et al. Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. 2017 Brain Res. pmid:28336272
Crascì L et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. 2017 Planta Med. pmid:28288492
Zhang S et al. Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation. 2017 Mol. Immunol. pmid:28288411
Zhao G et al. Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. 2017 Oncol. Rep. pmid:28260058
Bolzon LB et al. Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems. 2017 J. Inorg. Biochem. pmid:28236787
Liu HJ et al. Apigenin alleviates STZ-induced diabetic cardiomyopathy. 2017 Mol. Cell. Biochem. pmid:28176247
Maher HM et al. Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS. 2017 J Pharm Biomed Anal pmid:28167419
Wei X et al. Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. 2017 Clin. Sci. pmid:28143892
Espargaró A et al. Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. 2017 J. Nat. Prod. pmid:28128562
Zhou Z et al. Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. 2017 Anticancer Drugs pmid:28125432
Erdogan S et al. The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. 2017 Biomed. Pharmacother. pmid:28107698
Thirusangu P et al. Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. 2017 Biochem. Biophys. Res. Commun. pmid:28104392
Wang F et al. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. 2017 Chem. Biol. Interact. pmid:28803762
Gaballah HH et al. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. 2017 Toxicol. Appl. Pharmacol. pmid:28025107
Hithamani G et al. Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells. 2017 J. Biosci. pmid:29229878
Tseng TH et al. Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. 2017 Environ. Toxicol. pmid:26872304
Zou Z et al. Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii. 2017 Fitoterapia pmid:27889540
Zou Z et al. Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. 2017 Phytochemistry pmid:27889245
Ketkaew Y et al. Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. 2017 Arch. Oral Biol. pmid:27886571
Liu H et al. Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. 2017 J Chromatogr Sci pmid:27884870
Wu CY et al. Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration. 2017 Curr. Med. Chem. pmid:27855618
Guo TT et al. Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. 2017 J Asian Nat Prod Res pmid:27848262
Sharma N et al. Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativus Targeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena. 2017 Med Chem pmid:27834134
Tang D et al. Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. 2017 Expert Opin Drug Metab Toxicol pmid:27766890
Wen L et al. Identification of a flavonoid C-glycoside as potent antioxidant. 2017 Free Radic. Biol. Med. pmid:28587909
Wong TY et al. Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. 2017 Biomed. Pharmacother. pmid:29198743
Salazar-Aguilar S et al. Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. 2017 Nutrients pmid:28757593
Gao Y et al. Hepatic, gastric and intestinal first-pass effects of vitexin-2''-O-rhamnoside in rats by ultra-high-performance liquid chromatography. 2016 Biomed. Chromatogr. pmid:26031900
Cardenas H et al. Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function. 2016 Int J Mol Sci pmid:26938530
García-Martínez O et al. Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation. 2016 PLoS ONE pmid:26930190
Dong ZX et al. An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin. 2016 Molecules pmid:26927039
Cao HH et al. Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma. 2016 Sci Rep pmid:26911838
Wu G et al. Growth temperature and genotype both play important roles in sorghum grain phenolic composition. 2016 Sci Rep pmid:26907726
Bridgeman BB et al. Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention. 2016 Cell. Signal. pmid:26876613
Verma S et al. Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations. 2016 PLoS ONE pmid:26863418
Asanagi M et al. Tributyltin induces G2/M cell cycle arrest via NAD(+)-dependent isocitrate dehydrogenase in human embryonic carcinoma cells. 2016 J Toxicol Sci pmid:26961604
Pápay ZE et al. Development of oral site-specific pellets containing flavonoid extract with antioxidant activity. 2016 Eur J Pharm Sci pmid:27989856
He M et al. A review on the pharmacological effects of vitexin and isovitexin. 2016 Fitoterapia pmid:27693342
Dai J et al. Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. 2016 Toxicol. Appl. Pharmacol. pmid:27664007
Mudge EM et al. Single-Laboratory Validation for the Determination of Flavonoids in Hawthorn Leaves and Finished Products by LC-UV. 2016 Planta Med. pmid:27776376
Whitehouse S et al. Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties. 2016 Phytomedicine pmid:27765370
Li Q et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. 2016 J Clin Neurosci pmid:27742373
Choi S et al. Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo. 2016 Int. J. Mol. Med. pmid:27279007
Hlila MB et al. Characterisation of phenolic antioxidants in Scabiosa arenaria flowers by LC-ESI-MS/MS and NMR. 2016 J. Pharm. Pharmacol. pmid:27230582
Terpinc P et al. LC-MS analysis of phenolic compounds and antioxidant activity of buckwheat at different stages of malting. 2016 Food Chem pmid:27211614
Kandhare AD et al. Development and validation of HPLC method for vicenin-1 isolated from fenugreek seeds in rat plasma: application to pharmacokinetic, tissue distribution and excretion studies. 2016 Pharm Biol pmid:27181500
Liu M et al. Rapid screening of transferrin-binders in the flowers of Bauhinia blakeana Dunn by on-line high-performance liquid chromatography-diode-array detector-electrospray ionization-ion-trap-time-of-flight-mass spectrometry-transferrin-fluorescence detection system. 2016 J Chromatogr A pmid:27178150
Karamese M et al. Anti-oxidant and anti-inflammatory effects of apigenin in a rat model of sepsis: an immunological, biochemical, and histopathological study. 2016 Immunopharmacol Immunotoxicol pmid:27144896
Ren B et al. Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats. 2016 Eur. J. Pharmacol. pmid:26801071
Dos Santos KC et al. Passiflora actinia hydroalcoholic extract and its major constituent, isovitexin, are neuroprotective against glutamate-induced cell damage in mice hippocampal slices. 2016 J. Pharm. Pharmacol. pmid:26800497
Luan RL et al. Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice. 2016 Inflammation pmid:26782361
Wang Z et al. Scutellarin protects cardiomyocyte ischemia-reperfusion injury by reducing apoptosis and oxidative stress. 2016 Life Sci. pmid:26775564
Ku SK and Bae JS Vicenin-2 and scolymoside inhibit high-glucose-induced vascular inflammation in vitro and in vivo. 2016 Can. J. Physiol. Pharmacol. pmid:26766560
Hou K et al. Ionic liquids-lithium salts pretreatment followed by ultrasound-assisted extraction of vitexin-4″-O-glucoside, vitexin-2″-O-rhamnoside and vitexin from Phyllostachys edulis leaves. 2016 J Chromatogr A pmid:26763300
Guimarães R et al. Wild Roman chamomile extracts and phenolic compounds: enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase. 2016 Food Funct pmid:26446815
Li R et al. Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain. 2016 Behav. Brain Res. pmid:26416673
Pápay ZE et al. Comparative evaluation of the effect of cyclodextrins and pH on aqueous solubility of apigenin. 2016 J Pharm Biomed Anal pmid:26363816
Venditti A et al. Phytochemical analysis of Achillea ligustica All. from Lipari Island (Aeolian Islands). 2016 Nat. Prod. Res. pmid:26327332