apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Asthma D001249 52 associated lipids
Thrombosis D013927 49 associated lipids
Precancerous Conditions D011230 48 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Memory Disorders D008569 33 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Abdelhady MI et al. Bioassay-guided isolation and POM analyses of a new immunomodulatory polyphenolic constituent from Callistemon viridiflorus. 2016 Nat. Prod. Res. pmid:26156551
Veltmann M et al. Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. 2016 PLoS ONE pmid:26800359
Chen M et al. Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner. 2016 Sci Rep pmid:27752089
Zhang YY et al. Enzymatic production of oroxylin A and hispidulin using a liverwort flavone 6-O-methyltransferase. 2016 FEBS Lett. pmid:27432544
Schuster R et al. Cajanus cajan- a source of PPARγ activators leading to anti-inflammatory and cytotoxic effects. 2016 Food Funct pmid:27603115
Siragusa L et al. Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case. 2016 ChemMedChem pmid:27404817
He JD et al. Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway. 2016 Oncotarget pmid:27588401
Feng X et al. Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization. 2016 EBioMedicine pmid:27374313
Muhammad AA et al. Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. 2016 Drug Des Devel Ther pmid:27307703
Qin Y et al. Apigenin inhibits NF-κB and snail signaling, EMT and metastasis in human hepatocellular carcinoma. 2016 Oncotarget pmid:27203387
Xie Y et al. Preparative Separation and Purification of the Total Flavonoids in Scorzonera austriaca with Macroporous Resins. 2016 Molecules pmid:27304948
Hu Y et al. Synthetic investigation toward apigenin 5-O-glycoside camellianin B as well as the chemical structure revision. 2016 Org. Biomol. Chem. pmid:27145917
Peng HY et al. Apigenin-7-O-β-D-glycoside isolation from the highly copper-tolerant plant Elsholtzia splendens. 2016 J Zhejiang Univ Sci B pmid:27256678
Hawrył A et al. TLC Profiles of Selected Cirsium Species with Chemometrics in Construction of Their Fingerprints. 2016 J Chromatogr Sci pmid:27130878
Jung UJ et al. Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice. 2016 Nutrients pmid:27213439
Yuan Y et al. Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia. 2016 Neuromolecular Med. pmid:27103430
Pérez-Montaño F et al. RNA-seq analysis of the Rhizobium tropici CIAT 899 transcriptome shows similarities in the activation patterns of symbiotic genes in the presence of apigenin and salt. 2016 BMC Genomics pmid:26951045
Cardenas H et al. Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function. 2016 Int J Mol Sci pmid:26938530
García-Martínez O et al. Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation. 2016 PLoS ONE pmid:26930190
Dong ZX et al. An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin. 2016 Molecules pmid:26927039
Cao HH et al. Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma. 2016 Sci Rep pmid:26911838
Wu G et al. Growth temperature and genotype both play important roles in sorghum grain phenolic composition. 2016 Sci Rep pmid:26907726
Bridgeman BB et al. Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention. 2016 Cell. Signal. pmid:26876613
Verma S et al. Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations. 2016 PLoS ONE pmid:26863418
Fonseca-Silva F et al. Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action. 2016 PLoS Negl Trop Dis pmid:26862901
Zhu Q et al. Antinociceptive effects of vitexin in a mouse model of postoperative pain. 2016 Sci Rep pmid:26763934
Wang W et al. Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor. 2016 PLoS ONE pmid:26730961
Lv H et al. Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways. 2016 Int. J. Biol. Sci. pmid:26722219
Asanagi M et al. Tributyltin induces G2/M cell cycle arrest via NAD(+)-dependent isocitrate dehydrogenase in human embryonic carcinoma cells. 2016 J Toxicol Sci pmid:26961604
Ginwala R et al. Apigenin, a Natural Flavonoid, Attenuates EAE Severity Through the Modulation of Dendritic Cell and Other Immune Cell Functions. 2016 J Neuroimmune Pharmacol pmid:26040501
Balez R et al. Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease. 2016 Sci Rep pmid:27514990
Zhu H et al. Apigenin induced apoptosis in esophageal carcinoma cells by destruction membrane structures. 2016 Scanning pmid:26435325
Lin F et al. [Inhibitory effect of jianpi-jiedu prescription-contained serum on colorectal cancer SW48 cell proliferation by mTOR-P53-P21 signalling pathway]. 2016 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:27932756
Shu L et al. [Effects of apigenin on self-renewal and 
uPAR expression in NCI-H446 cell line]. 2016 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:27932755
Yagishita Y et al. Photochromic Properties of 3-Deoxyanthocyanidin Pigments in Nontoxic Solvents. 2016 J. Food Sci. pmid:27925261
Wakx A et al. New in vitro biomarkers to detect toxicity in human placental cells: The example of benzo[A]pyrene. 2016 Toxicol In Vitro pmid:26657896
Chen L et al. Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways. 2016 Mol Med Rep pmid:27878303
Lim HS et al. Apigetrin from Scutellaria baicalensis Georgi Inhibits Neuroinflammation in BV-2 Microglia and Exerts Neuroprotective Effect in HT22 Hippocampal Cells. 2016 J Med Food pmid:27845861
Kim A et al. Apigenin Reduces Proteasome Inhibition-Induced Neuronal Apoptosis by Suppressing the Cell Death Process. 2016 Neurochem. Res. pmid:27473386
Das MC et al. Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin. 2016 Sci Rep pmid:27000525
Hakobyan A et al. Apigenin inhibits African swine fever virus infection in vitro. 2016 Arch. Virol. pmid:27638776
Coelho PL et al. The flavonoid apigenin from Croton betulaster Mull inhibits proliferation, induces differentiation and regulates the inflammatory profile of glioma cells. 2016 Anticancer Drugs pmid:27622606
Xiao L et al. A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP. 2016 Eur J Pharm Sci pmid:27586020
Zeng L et al. Inhibitory Mechanism of Apigenin on α-Glucosidase and Synergy Analysis of Flavonoids. 2016 J. Agric. Food Chem. pmid:27581205
Erdogan S et al. The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling. 2016 Life Sci. pmid:27569589
Mendel M et al. Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study. 2016 Animal pmid:27534882
Huang Y et al. Preparation of inclusion complex of apigenin-hydroxypropyl-β-cyclodextrin by using supercritical antisolvent process for dissolution and bioavailability enhancement. 2016 Int J Pharm pmid:27515291
Večeřová K et al. Changes of primary and secondary metabolites in barley plants exposed to CdO nanoparticles. 2016 Environ. Pollut. pmid:27503055
Qin W et al. Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose. 2016 Vascul. Pharmacol. pmid:27473516
Aseervatham GS et al. Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice. 2016 Biomed. Pharmacother. pmid:27470339
Salami M et al. Inhibitory effect of different fennel (Foeniculum vulgare) samples and their phenolic compounds on formation of advanced glycation products and comparison of antimicrobial and antioxidant activities. 2016 Food Chem pmid:27451172
Liu L et al. Luteolin and apigenin activate the Oct-4/Sox2 signal via NFATc1 in human periodontal ligament cells. 2016 Cell Biol. Int. pmid:27449921
Pan G et al. Total synthesis of 8-(6″-umbelliferyl)-apigenin and its analogs as anti-diabetic reagents. 2016 Eur J Med Chem pmid:27448923
Chen XJ et al. Apigenin inhibits glioma cell growth through promoting microRNA-16 and suppression of BCL-2 and nuclear factor-κB/MMP‑9. 2016 Mol Med Rep pmid:27430517
Das LK et al. Three new acyltyramines from Anisodus luridus Link et Otto (Solanaceae). 2016 Nat. Prod. Res. pmid:27406583
He X et al. Protective role of apigenin in cisplatin-induced renal injury. 2016 Eur. J. Pharmacol. pmid:27388142
Coombs MR et al. Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells. 2016 Cancer Lett. pmid:27378243
Velikova V et al. Physiological significance of isoprenoids and phenylpropanoids in drought response of Arundinoideae species with contrasting habitats and metabolism. 2016 Plant Cell Environ. pmid:27351898
Cattaneo F et al. Flour from Prosopis alba cotyledons: A natural source of nutrient and bioactive phytochemicals. 2016 Food Chem pmid:27132827
Freitas JV and Gaspar LR In vitro photosafety and efficacy screening of apigenin, chrysin and beta-carotene for UVA and VIS protection. 2016 Eur J Pharm Sci pmid:27130544
Seydi E et al. Selective Toxicity of Apigenin on Cancerous Hepatocytes by Directly Targeting their Mitochondria. 2016 Anticancer Agents Med Chem pmid:27109019
Fang M et al. Scutellarin promotes microglia-mediated astrogliosis coupled with improved behavioral function in cerebral ischemia. 2016 Neurochem. Int. pmid:27105682
Wang X et al. Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer. 2016 Fitoterapia pmid:27102611
Dubois N et al. Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential. 2016 Int. J. Oncol. pmid:27098015
Simeonova R et al. Antidiabetic and antioxidant effects of saponarin from Gypsophila trichotoma on streptozotocin-induced diabetic normotensive and hypertensive rats. 2016 Phytomedicine pmid:27064007
Kim BK et al. Enhancing oral bioavailability using preparations of apigenin-loaded W/O/W emulsions: In vitro and in vivo evaluations. 2016 Food Chem pmid:27041302
Jiang Z et al. Determination of scutellarin in breviscapine preparations using quantitative proton nuclear magnetic resonance spectroscopy. 2016 J Food Drug Anal pmid:28911594
Márquez-Flores YK et al. Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways. 2016 J. Nutr. Biochem. pmid:27012631
Lee HE et al. Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property. 2016 Behav. Brain Res. pmid:26996316
Zhu ZY et al. Apigenin ameliorates hypertension-induced cardiac hypertrophy and down-regulates cardiac hypoxia inducible factor-lα in rats. 2016 Food Funct pmid:26987380
Lim W et al. Apigenin Reduces Survival of Choriocarcinoma Cells by Inducing Apoptosis via the PI3K/AKT and ERK1/2 MAPK Pathways. 2016 J. Cell. Physiol. pmid:26970256
Xiong Z et al. Mushroom (Agaricus bisporus) polyphenoloxidase inhibited by apigenin: Multi-spectroscopic analyses and computational docking simulation. 2016 Food Chem pmid:26948635
Fu L et al. Mechanism evaluation of the interactions between flavonoids and bovine serum albumin based on multi-spectroscopy, molecular docking and Q-TOF HR-MS analyses. 2016 Food Chem pmid:26948600
Srinivas NR Is the inhibition of the liver uptake and biliary excretion, via transporters, the likely mechanism for the increased exposure of vitexin-2''-O-rhamnoside with bile salts in rats? 2016 Biomed. Chromatogr. pmid:26928602
Kesavan R et al. Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration. 2016 Nutr Metab Cardiovasc Dis pmid:26868432
Abugri DA et al. In vitro activity of Sorghum bicolor extracts, 3-deoxyanthocyanidins, against Toxoplasma gondii. 2016 Exp. Parasitol. pmid:26855040
Weng L et al. Apigenin reverses depression-like behavior induced by chronic corticosterone treatment in mice. 2016 Eur. J. Pharmacol. pmid:26826594
Dong ZX et al. Design, Synthesis, and Biological Evaluation of Scutellarein Derivatives Based on Scutellarin Metabolic Mechanism In Vivo. 2016 Chem Biol Drug Des pmid:26808289
Han F et al. Application of alkyl polyglycoside surfactant in ultrasonic-assisted extraction followed by macroporous resin enrichment for the separation of vitexin-2″-O-rhamnoside and vitexin from Crataegus pinnatifida leaves. 2016 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:26807707
Yang MH et al. A new flavone C-glycoside and a new bibenzyl from Bulbophyllum retusiusculum. 2016 Nat. Prod. Res. pmid:26729275
Nasr-Bouzaiene N et al. Immunomodulatory and cellular antioxidant activities of pure compounds from Teucrium ramosissimum Desf. 2016 Tumour Biol. pmid:26692099
Zhang S et al. Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice. 2016 Inflammation pmid:26658748
Fan J et al. Shear rheology and in-vitro release kinetic study of apigenin from lyotropic liquid crystal. 2016 Int J Pharm pmid:26657272
Nasr Bouzaiene N et al. Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. 2016 Life Sci. pmid:26656314
Romero GB et al. Simple low-cost miniaturization approach for pharmaceutical nanocrystals production. 2016 Int J Pharm pmid:26642945
Basios N et al. Apigenin Attenuates Inflammation in Experimentally Induced Acute Pancreatitis-Associated Lung Injury. 2016 J Invest Surg pmid:26631908
Lee IC and Bae JS Anti-inflammatory effects of vicenin-2 and scolymoside on polyphosphate-mediated vascular inflammatory responses. 2016 Inflamm. Res. pmid:26621502
Lou SN et al. Phenolic content, antioxidant activity and effective compounds of kumquat extracted by different solvents. 2016 Food Chem pmid:26616917
Mostafa NM et al. Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae). 2016 Nat. Prod. Res. pmid:26594904
Kawamura H et al. Ultrasonically enhanced extraction of luteolin and apigenin from the leaves of Perilla frutescens (L.) Britt. using liquid carbon dioxide and ethanol. 2016 Ultrason Sonochem pmid:26584980
Lee YM et al. Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress. 2016 Int. J. Oncol. pmid:26573871
Wang WW et al. Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells. 2016 J. Mol. Neurosci. pmid:26514969
Chen C et al. Involvement of Bcl-2 Signal Pathway in the Protective Effects of Apigenin on Anoxia/Reoxygenation-induced Myocardium Injury. 2016 J. Cardiovasc. Pharmacol. pmid:26466327
Rosa SI et al. Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway. 2016 Phytomedicine pmid:26902402
Patil RH et al. Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells. 2016 Inflammation pmid:26276128
Cochran DB et al. Degradable poly(apigenin) polymer inhibits tumor cell adhesion to vascular endothelial cells. 2016 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:26251070
Zou H et al. Two new flavonoids from Selaginella uncinata. 2016 J Asian Nat Prod Res pmid:26238803
Kubínová R et al. Anticholinesterase, antioxidant activity and phytochemical investigation into aqueous extracts from five species of Agrimonia genus. 2016 Nat. Prod. Res. pmid:26235662
Iqbal MK et al. Recovery of Chicken Growth Plate by Heat-Shock Protein 90 Inhibitors Epigallocatechin-3-Gallate and Apigenin in Thiram-Induced Tibial Dyschondroplasia. 2016 Avian Dis. pmid:27902918
Buwa CC et al. Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System. 2016 Cardiovasc. Toxicol. pmid:26186996