apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Asthma D001249 52 associated lipids
Thrombosis D013927 49 associated lipids
Precancerous Conditions D011230 48 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Memory Disorders D008569 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Makino T et al. Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. 2001 Biol. Pharm. Bull. pmid:11642335
Vrinda B and Uma Devi P Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin. 2001 Mutat. Res. pmid:11673069
Shen J et al. Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. 2001 J. Immunol. pmid:11673497
Bylka W Isovitexin o-glucosides from Aquilegia vulgaris L. 2001 Jul-Aug Acta Pol Pharm pmid:11693732
Brahmbhatt SR et al. Study of biochemical prevalence indicators for the assessment of iodine deficiency disorders in adults at field conditions in Gujarat (India). 2001 Asia Pac J Clin Nutr pmid:11708609
Boveris AD et al. Antioxidant capacity of a 3-deoxyanthocyanidin from soybean. 2001 Phytochemistry pmid:11730874
Lans C et al. Medicinal and ethnoveterinary remedies of hunters in Trinidad. 2001 BMC Complement Altern Med pmid:11737880
Lu J et al. Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils. 2002 Clin. Chim. Acta pmid:11750278
Lautraite S et al. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. 2002 Mutagenesis pmid:11752233
Fiorani M et al. Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes. 2002 Free Radic. Biol. Med. pmid:11755318
Kitada C et al. Differential expression of two cytochrome P450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of Perilla frutescens. 2001 Plant Cell Physiol. pmid:11773526
Kobayashi T et al. Effect of flavonoids on cell cycle progression in prostate cancer cells. 2002 Cancer Lett. pmid:11790449
Llorens F et al. Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation. 2002 FEBS Lett. pmid:11801244
Lorentz A et al. Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins. 2002 Blood pmid:11807000
McVean M et al. A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin. 2002 Mol. Carcinog. pmid:11807956
Tatsuta A et al. Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. 2000 Clin. Exp. Metastasis pmid:11827069
Landesman-Bollag E et al. Protein kinase CK2: signaling and tumorigenesis in the mammary gland. 2001 Mol. Cell. Biochem. pmid:11827167
Lee WR et al. Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. 2002 Biochem. Pharmacol. pmid:11841797
Frangne N et al. Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. 2002 Plant Physiol. pmid:11842175
Rozema J et al. The role of UV-B radiation in aquatic and terrestrial ecosystems--an experimental and functional analysis of the evolution of UV-absorbing compounds. 2002 J. Photochem. Photobiol. B, Biol. pmid:11849977