| MeSH term | MeSH ID | Detail |
|---|---|---|
| Nerve Degeneration | D009410 | 53 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oku H et al. | Antipruritic effects of the fruits of Chaenomeles sinensis. | 2003 | Biol. Pharm. Bull. | pmid:12843634 |
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| Sikorska M et al. | Application of mass spectrometric techniques for structural analysis of apigenin 8-C-(6"-O-glucopyranosyl) glucopyranoside--a novel flavonoid C-diglycoside. | 2003 | Rapid Commun. Mass Spectrom. | pmid:12811762 |
| Miller CP et al. | Constrained phytoestrogens and analogues as ERbeta selective ligands. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12824043 |
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| Schulte-Löbbert S et al. | Development of a high-performance-liquid-chromatographic method for the determination of biapigenin in biorelevant media. | 2003 | J Pharm Biomed Anal | pmid:12946531 |
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| Boué SM et al. | Identification of flavone aglycones and glycosides in soybean pods by liquid chromatography-tandem mass spectrometry. | 2003 | J Chromatogr A | pmid:12703901 |
| Zhu F et al. | [Effect of emodin and apigenin on invasion of human ovarian carcinoma HO-8910PM cells in vitro]. | 2003 | Ai Zheng | pmid:12703988 |
| Nakazawa T et al. | Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test. | 2003 | Biol. Pharm. Bull. | pmid:12673028 |
| Ogawa M et al. | Nuclear translocation of Xenopus laevis paxillin. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12727207 |
| Hessenauer A et al. | Inhibition of CK2 activity provokes different responses in hormone-sensitive and hormone-refractory prostate cancer cells. | 2003 | Int. J. Oncol. | pmid:12738992 |
| Wang M et al. | Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). | 2003 | J. Agric. Food Chem. | pmid:12537429 |
| Beyer G and Melzig MF | Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells. | 2003 | Planta Med. | pmid:14750029 |
| Smolinski AT and Pestka JJ | Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew). | 2003 | Food Chem. Toxicol. | pmid:12909272 |
| Dias C et al. | Structural elucidation of natural 2-hydroxy di- and tricarboxylic acids and esters, phenylpropanoid esters and a flavonoid from Autonoë madeirensis using gas chromatographic/electron ionization, electrospray ionization and tandem mass spectrometric techniques. | 2003 | J Mass Spectrom | pmid:14696202 |
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| Simirgiotis MJ et al. | New dammarane triterpenes from the aerial parts of Ibicella lutea grown in Argentina. | 2003 | J. Nat. Prod. | pmid:14695802 |
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| Hou CC et al. | Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica. | 2003 | J. Nat. Prod. | pmid:12762795 |
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| Owen RW et al. | Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes. | 2003 | Food Chem. Toxicol. | pmid:12659724 |
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| McPhail DB et al. | Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. | 2003 | J. Agric. Food Chem. | pmid:12617605 |
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| Koo H et al. | Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. | 2003 | J. Antimicrob. Chemother. | pmid:14563892 |
| Naderi GA et al. | Anti-oxidant effect of flavonoids on the susceptibility of LDL oxidation. | 2003 | Mol. Cell. Biochem. | pmid:12841362 |
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| Zhong D et al. | Determination of scutellarin in rat plasma by high-performance liquid chromatography with ultraviolet detection. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14581083 |
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| Cushnie TP et al. | Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports. | 2003 | Microbiol. Res. | pmid:14717448 |
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| Kim MH | Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases. | 2003 | J. Cell. Biochem. | pmid:12761886 |
| Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
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| Sasaki N et al. | Protective effects of flavonoids on the cytotoxicity of linoleic acid hydroperoxide toward rat pheochromocytoma PC12 cells. | 2003 | Chem. Biol. Interact. | pmid:12606158 |
| Orska-GawryÅ› J et al. | Identification of natural dyes in archeological Coptic textiles by liquid chromatography with diode array detection. | 2003 | J Chromatogr A | pmid:12650256 |
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| Engelmann C et al. | Apigenin--strong cytostatic and anti-angiogenic action in vitro contrasted by lack of efficacy in vivo. | 2002 | Phytomedicine | pmid:12403156 |
| Droillard M et al. | Different protein kinase families are activated by osmotic stresses in Arabidopsis thaliana cell suspensions. Involvement of the MAP kinases AtMPK3 and AtMPK6. | 2002 | FEBS Lett. | pmid:12220631 |
| Takahama U et al. | Oxidation of quercetin by salivary components. Quercetin-dependent reduction of salivary nitrite under acidic conditions producing nitric oxide. | 2002 | J. Agric. Food Chem. | pmid:12105964 |
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| Salah AM et al. | Estrogenic and cholinergic properties of the methanol extract of Ruellia praetermissa Sceinf. ex. Lindau (Acanthaceae) in female rats. | 2002 | Phytomedicine | pmid:11924764 |
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| Koo H et al. | Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. | 2002 | Oral Microbiol. Immunol. | pmid:12485324 |
| Wang H et al. | Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex. | 2002 | Planta Med. | pmid:12494329 |
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| Han DH et al. | Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224631 |
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