apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Chromosomal Instability D043171 5 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
Cocaine-Related Disorders D019970 3 associated lipids
Lymphoma, Primary Effusion D054685 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
pmid:
Aljancić I et al. Flavones and sesquiterpene lactones from Achillea atrata subsp. multifida: antimicrobial activity. 1999 J. Nat. Prod. pmid:10395518
Jeong HJ et al. Inhibition of aromatase activity by flavonoids. 1999 Arch. Pharm. Res. pmid:10403137
Takasaki M et al. Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens. 1999 J. Nat. Prod. pmid:10425119
Afifi FU et al. Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs. 1999 J Ethnopharmacol pmid:10465658
Dekermendjian K et al. Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex. 1999 J. Med. Chem. pmid:10543878
Yin F et al. Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). 1999 Sep-Oct Anticancer Res. pmid:10628390
Breinholt V et al. Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. 1999 Xenobiotica pmid:10647909
Galijatovic A et al. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. 1999 Xenobiotica pmid:10647910
Segaert S et al. The flavonoid apigenin suppresses vitamin D receptor expression and vitamin D responsiveness in normal human keratinocytes. 2000 Biochem. Biophys. Res. Commun. pmid:10652242
Chan EC et al. Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. 2000 J. Cardiovasc. Pharmacol. pmid:10672869
Wang IK et al. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. 1999 Eur. J. Cancer pmid:10673981
Pieroni A and Pachaly P Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L. 2000 Pharmazie pmid:10683879
Trochon V et al. Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression. 2000 Int. J. Cancer pmid:10699950
Nakazawa T and Ohsawa K Metabolites of orally administered Perilla frutescens extract in rats and humans. 2000 Biol. Pharm. Bull. pmid:10706426
Hiremath SP et al. Antifertility and hormonal properties of flavones of Striga orobanchioides. 2000 Eur. J. Pharmacol. pmid:10720651
Romanová D et al. Determination of apigenin in rat plasma by high-performance liquid chromatography. 2000 J Chromatogr A pmid:10722103
Avallone R et al. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. 2000 Biochem. Pharmacol. pmid:10751547
McVean M et al. Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes. 2000 Carcinogenesis pmid:10753197
O'Gorman DM et al. Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals. 2000 Leukemia pmid:10764145
Song DH et al. Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. 2000 J. Biol. Chem. pmid:10806215
Bible KC et al. Flavopiridol binds to duplex DNA. 2000 Cancer Res. pmid:10811119
Pieroni A et al. Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae). 2000 J Ethnopharmacol pmid:10837985
Wang W et al. Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines. 2000 Mol. Carcinog. pmid:10900467
Caltagirone S et al. Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. 2000 Int. J. Cancer pmid:10918203
Yoshikawa M et al. Medicinal foodstuffs. XVIII. Phytoestrogens from the aerial part of Petroselinum crispum MIll. (Parsley) and structures of 6"-acetylapiin and a new monoterpene glycoside, petroside. 2000 Chem. Pharm. Bull. pmid:10923837
Ecay TW et al. Wortmannin inhibition of forskolin-stimulated chloride secretion by T84 cells. 2000 Biochim. Biophys. Acta pmid:10930508
Zanoli P et al. Behavioral characterisation of the flavonoids apigenin and chrysin. 2000 Fitoterapia pmid:10930722
Breinholt V et al. Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. 2000 Food Chem. Toxicol. pmid:10942316
Mucaji P et al. [Apigenin-7-methylglucuronide from Cynara cardunculus L]. 2000 Ceska Slov Farm pmid:10953447
Uma Devi P et al. Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. 2000 Radiat. Res. pmid:11023610
De Santi C et al. Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. 2000 Xenobiotica pmid:11055264
Iwashita K et al. Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. 2000 Biosci. Biotechnol. Biochem. pmid:11055382
Illek B et al. Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin. 2000 Am. J. Physiol., Cell Physiol. pmid:11078699
Wang CN et al. The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. 2001 J. Biol. Chem. pmid:11083861
Chen SB et al. Aquiledine and isoaquiledine, novel flavonoid alkaloids from Aquilegia ecalcarata. 2001 J. Nat. Prod. pmid:11170673
Galati G et al. Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation. 2001 Free Radic. Biol. Med. pmid:11182292
de Santi C et al. Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. 2000 Xenobiotica pmid:11197066
Greenham J et al. A distinctive flavonoid chemistry for the anomalous genus Biebersteinia. 2001 Phytochemistry pmid:11198823
Carini M et al. LC coupled to ion-trap MS for the rapid screening and detection of polyphenol antioxidants from Helichrysum stoechas. 2001 J Pharm Biomed Anal pmid:11199231
Al-Okla S et al. Involvement of alpha5beta1 integrins in interleukin 8 production induced by oral viridans streptococcal protein I/IIf in cultured endothelial cells. 1999 Cell. Microbiol. pmid:11207549
Raso GM et al. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. 2001 Life Sci. pmid:11213362
Ashida H Suppressive effects of flavonoids on dioxin toxicity. 2000 Biofactors pmid:11216487
Heijnen CG et al. Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. 2001 Toxicol In Vitro pmid:11259863
Mitchell KA et al. Flavonoid characters contributing to the taxonomic revision of the Hebe parviflora complex. 2001 Phytochemistry pmid:11261578
Stochmal A et al. Alfalfa (Medicago sativa L.) flavonoids. 1. Apigenin and luteolin glycosides from aerial parts. 2001 J. Agric. Food Chem. pmid:11262024
Makino T et al. Inhibitory effect of decoction of Perilla frutescens on cultured murine mesangial cell proliferation and quantitative analysis of its active constituents. 2001 Planta Med. pmid:11270716
Hanyaloglu AC et al. Casein kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimeric gonadotropin-releasing hormone receptors contribute to beta-arrestin-dependent internalization. 2001 J. Biol. Chem. pmid:11278484
Yin F et al. Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. 2001 Jan-Feb Anticancer Res. pmid:11299771
Leslie EM et al. Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. 2001 Mol. Pharmacol. pmid:11306701