| MeSH term | MeSH ID | Detail |
|---|---|---|
| Chromosomal Instability | D043171 | 5 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Cocaine-Related Disorders | D019970 | 3 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rodriguez IF et al. | Morphological, histological, chemical and functional characterization of Prosopis alba flours of different particle sizes. | 2019 | Food Chem | pmid:30372982 |
| Li ZM et al. | Vitexin alleviates streptozotocin-induced sexual dysfunction and fertility impairments in male mice via modulating the hypothalamus-pituitary-gonadal axis. | 2019 | Chem. Biol. Interact. | pmid:30365938 |
| Baruah TJ et al. | Vicenin-2: a potential radiosensitizer of non-small cell lung cancer cells. | 2018 | Mol. Biol. Rep. | pmid:30099686 |
| Chen S et al. | A UPLC-ESI-MS/MS Method for Simultaneous Quantitation of Chlorogenic Acid, Scutellarin, and Scutellarein in Rat Plasma: Application to a Comparative Pharmacokinetic Study in Sham-Operated and MCAO Rats after Oral Administration of Extract. | 2018 | Molecules | pmid:30037063 |
| Yang M et al. | Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway. | 2018 | Biomed. Pharmacother. | pmid:30021365 |
| van Dooren I et al. | In vitro gastrointestinal biotransformation and characterization of a Desmodium adscendens decoction: the first step in unravelling its behaviour in the human body. | 2018 | J. Pharm. Pharmacol. | pmid:30003542 |
| Okitsu N et al. | Identification and Characterization of Novel Nemophila menziesii Flavone Glucosyltransferases that Catalyze Biosynthesis of Flavone 7,4'-O-Diglucoside, a Key Component of Blue Metalloanthocyanins. | 2018 | Plant Cell Physiol. | pmid:29986079 |
| Mekawy AMM et al. | Apigenin pretreatment enhances growth and salinity tolerance of rice seedlings. | 2018 | Plant Physiol. Biochem. | pmid:29980098 |
| Lorizola IM et al. | Beet Stalks and Leaves ( L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice. | 2018 | Nutrients | pmid:29976910 |
| Gao AM et al. | Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis. | 2018 | Chem. Biol. Interact. | pmid:29191453 |
| Zhang Y et al. | Apigenin suppresses mouse peritoneal fibrosis by down-regulating miR34a expression. | 2018 | Biomed. Pharmacother. | pmid:29966983 |
| Wong TY et al. | Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters. | 2018 | J. Pharm. Pharmacol. | pmid:29943490 |
| Bai HH et al. | Hydroxycinnamoylmalated flavone C-glycosides from Lemna japonica. | 2018 | Fitoterapia | pmid:29154864 |
| Jiang PY et al. | Protective effects of apigenin on LPS-induced endometritis via activating Nrf2 signaling pathway. | 2018 | Microb. Pathog. | pmid:29928944 |
| Zhou Z et al. | Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway. | 2018 | Mol Med Rep | pmid:29901074 |
| Yang D et al. | Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line. | 2018 | Drug Des Devel Ther | pmid:29849451 |
| Bhattacharya S et al. | Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats. | 2018 | Nanomedicine | pmid:29802937 |
| Gu CB et al. | Characterization, culture medium optimization and antioxidant activity of an endophytic vitexin-producing fungus Dichotomopilus funicola Y3 from pigeon pea [Cajanus cajan (L.) Millsp.]. | 2018 | J. Appl. Microbiol. | pmid:29791772 |
| Zhu J et al. | Protective effects of Hand.- Mazz. (EBHM) extract in retinal neurodegeneration models. | 2018 | Mol. Vis. | pmid:29769797 |
| Amiri M et al. | Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice. | 2018 | Phytother Res | pmid:29748995 |
| Oliveira DR et al. | Flavones-bound in benzodiazepine site on GABA receptor: Concomitant anxiolytic-like and cognitive-enhancing effects produced by Isovitexin and 6-C-glycoside-Diosmetin. | 2018 | Eur. J. Pharmacol. | pmid:29738701 |
| Wu TC et al. | Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. | 2018 | Chem. Biol. Interact. | pmid:30016632 |
| Lim H et al. | Flavonoids interfere with NLRP3 inflammasome activation. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29960001 |
| Malar DS et al. | Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro-2a cells from glutamate toxicity. | 2018 | Life Sci. | pmid:29704481 |
| Hadrich F and Sayadi S | Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPARγ and CEBP-α. | 2018 | Lipids Health Dis | pmid:29695233 |
| Lu Y et al. | Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway. | 2018 | PLoS ONE | pmid:29694408 |
| Gurunathan S et al. | Antibacterial Efficacy of Silver Nanoparticles on Endometritis Caused by and in Dairy Cattle. | 2018 | Int J Mol Sci | pmid:29659523 |
| Karamać M et al. | Phenolic contents and antioxidant capacities of wild and cultivated white lupin (Lupinus albus L.) seeds. | 2018 | Food Chem | pmid:29655709 |
| Mo J et al. | Scutellarin protects against vascular endothelial dysfunction and prevents atherosclerosis via antioxidation. | 2018 | Phytomedicine | pmid:29655699 |
| Kumar KS et al. | Isolation, identification and characterization of apigenin from Justicia gendarussa and its anti-inflammatory activity. | 2018 | Int. Immunopharmacol. | pmid:29655057 |
| Paredes MD et al. | Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. | 2018 | Nutrients | pmid:29652818 |
| Zeng YQ et al. | Scutellarin Mitigates Aβ-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice. | 2018 | Molecules | pmid:29642616 |
| Gentile D et al. | The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. | 2018 | PLoS ONE | pmid:29641549 |
| Kalogiouri NP et al. | Application of an advanced and wide scope non-target screening workflow with LC-ESI-QTOF-MS and chemometrics for the classification of the Greek olive oil varieties. | 2018 | Food Chem | pmid:29606472 |
| Hu WJ et al. | Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling. | 2018 | Biomed. Pharmacother. | pmid:29604587 |
| Hu M et al. | Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway. | 2018 | Drug Des Devel Ther | pmid:29588573 |
| Elhennawy MG and Lin HS | Dose- and time-dependent pharmacokinetics of apigenin trimethyl ether. | 2018 | Eur J Pharm Sci | pmid:29574080 |
| Malar DS et al. | Vitexin inhibits Aβ induced toxicity in Neuro-2a cells by augmenting Nrf-2/HO-1 dependent antioxidant pathway and regulating lipid homeostasis by the activation of LXR-α. | 2018 | Toxicol In Vitro | pmid:29545167 |
| Yang YC and Wei MC | Development and characterization of a green procedure for apigenin extraction from Scutellaria barbata D. Don. | 2018 | Food Chem | pmid:29478557 |
| Jin UH et al. | Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. | 2018 | Toxicol. Sci. | pmid:29584932 |
| Venturini CL et al. | Vitexin inhibits inflammation in murine ovalbumin-induced allergic asthma. | 2018 | Biomed. Pharmacother. | pmid:29091859 |
| Yang B et al. | Pharmacokinetic comparison of seven major bioactive components in normal and depression model rats after oral administration of Baihe Zhimu decoction by liquid chromatography-tandem mass spectrometry. | 2018 | J Pharm Biomed Anal | pmid:28987996 |
| Akogou FU et al. | Extraction methods and food uses of a natural red colorant from dye sorghum. | 2018 | J. Sci. Food Agric. | pmid:28600852 |
| Bougioukas I et al. | Apigenin Reduces NF-κB and Subsequent Cytokine Production as Protective Effect in a Rodent Animal Model of Lung Ischemia-Reperfusion Injury. | 2018 | J Invest Surg | pmid:28340319 |
| Gadioli IL et al. | A systematic review on phenolic compounds in Passiflora plants: Exploring biodiversity for food, nutrition, and popular medicine. | 2018 | Crit Rev Food Sci Nutr | pmid:27645583 |
| Crascì L et al. | Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation. | 2018 | Drug Res (Stuttg) | pmid:29108086 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| van Vugt-Lussenburg BMA et al. | Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity. | 2018 | Reprod. Toxicol. | pmid:29162470 |
| Zhong Y et al. | Protective effects of apigenin against 3-MCPD-induced renal injury in rat. | 2018 | Chem. Biol. Interact. | pmid:30107153 |
| Kang CH et al. | Apigenin promotes TRAIL-mediated apoptosis regardless of ROS generation. | 2018 | Food Chem. Toxicol. | pmid:29247770 |