| MeSH term | MeSH ID | Detail |
|---|---|---|
| Premature Birth | D047928 | 6 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee W and Bae JS | Antithrombotic and antiplatelet activities of vicenin-2. | 2015 | Blood Coagul. Fibrinolysis | pmid:26126169 |
| Andueza A et al. | Oxidation pathways underlying the pro-oxidant effects of apigenin. | 2015 | Free Radic. Biol. Med. | pmid:26119779 |
| Granica S et al. | The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid sources of Agrimoniae herba--The pharmacopoeial plant material. | 2015 | J Pharm Biomed Anal | pmid:26092224 |
| Chen YJ et al. | Scutellarin attenuates endothelium-dependent aasodilation impairment induced by hypoxia reoxygenation, through regulating the PKG signaling pathway in rat coronary artery. | 2015 | Chin J Nat Med | pmid:25908623 |
| Paredes-Gonzalez X et al. | Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin. | 2015 | Biopharm Drug Dispos | pmid:25904312 |
| Li Y et al. | Pharmacokinetics and tissue distribution study of Isovitexin in rats by HPLC-MS/MS. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25902051 |
| Wang Q et al. | Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis. | 2015 | Int. Immunopharmacol. | pmid:25899084 |
| Shi T et al. | [Effect of apigenin on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis]. | 2015 | Zhonghua Gan Zang Bing Za Zhi | pmid:25880979 |
| Xu C et al. | Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines. | 2015 | Xenobiotica | pmid:25869249 |
| Wei L et al. | Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions. | 2015 | J Sep Sci | pmid:25866087 |
| Zhang G et al. | Effects of germination on the nutritional properties, phenolic profiles, and antioxidant activities of buckwheat. | 2015 | J. Food Sci. | pmid:25858540 |
| Wang Y et al. | Vitexin protects brain against ischemia/reperfusion injury via modulating mitogen-activated protein kinase and apoptosis signaling in mice. | 2015 | Phytomedicine | pmid:25837275 |
| Sang Z et al. | Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. | 2015 | Eur J Med Chem | pmid:25778991 |
| Fonseca-Silva F et al. | Effect of Apigenin on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction. | 2015 | J. Nat. Prod. | pmid:25768915 |
| Ju WZ et al. | Clinical tolerability and pharmacokinetics of Erigerontis hydroxybenzene injection: results of a randomized phase I study in healthy Chinese volunteers. | 2015 | Phytomedicine | pmid:25765839 |
| Nabavi SM et al. | Apigenin and Breast Cancers: From Chemistry to Medicine. | 2015 | Anticancer Agents Med Chem | pmid:25738871 |
| Barlas N and Karabulut G | Haematological and histopathological effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar female albino rats. | 2015 | Hum Exp Toxicol | pmid:25378093 |
| Zhang S et al. | Studies on the interaction of apigenin with calf thymus DNA by spectroscopic methods. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25459730 |
| Russo D et al. | Antioxidant activities and quali-quantitative analysis of different Smallanthus sonchifolius [(Poepp. and Endl.) H. Robinson] landrace extracts. | 2015 | Nat. Prod. Res. | pmid:25533266 |
| Heredia-Vieira SC et al. | Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves. | 2015 | J. Nat. Prod. | pmid:25517504 |
| Germanò MP et al. | Anti-angiogenic activity of Entada africana root. | 2015 | Nat. Prod. Res. | pmid:25482106 |
| Saeed M et al. | Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking. | 2015 | J. Nutr. Biochem. | pmid:25459885 |
| Scholz P and Keck CM | Flavonoid nanocrystals produced by ARTcrystal®-technology. | 2015 | Int J Pharm | pmid:25448550 |
| Wang XS et al. | Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats. | 2015 | Phytother Res | pmid:25447838 |
| Singh V et al. | Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells. | 2015 | Eur J Nutr | pmid:25408199 |
| Tang AQ et al. | Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3‑derived sphere-forming cells. | 2015 | Mol Med Rep | pmid:25405327 |
| Hu J et al. | Protective effect of apigenin on ischemia/reperfusion injury of the isolated rat heart. | 2015 | Cardiovasc. Toxicol. | pmid:25377428 |
| Hasnat MA et al. | Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition. | 2015 | Molecules | pmid:26633318 |
| Lee JA et al. | Resveratrol as a Bioenhancer to Improve Anti-Inflammatory Activities of Apigenin. | 2015 | Nutrients | pmid:26610561 |
| Fang M et al. | Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats. | 2015 | BMC Neurosci | pmid:26608466 |
| Mangoyi R et al. | Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri. | 2015 | BMC Complement Altern Med | pmid:26573005 |
| Morimoto Y et al. | Apigenin as an anti-quinolone-resistance antibiotic. | 2015 | Int. J. Antimicrob. Agents | pmid:26526895 |
| Seo HS et al. | Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. | 2015 | Biosci. Rep. | pmid:26500281 |
| Xia F et al. | Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus. | 2015 | Appl. Environ. Microbiol. | pmid:26475103 |
| Li L et al. | Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα. | 2015 | PLoS ONE | pmid:26440524 |
| Willenberg I et al. | Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity. | 2015 | PLoS ONE | pmid:26440517 |
| Shukla S et al. | Apigenin blocks IKKα activation and suppresses prostate cancer progression. | 2015 | Oncotarget | pmid:26435478 |
| Lakshmanan A et al. | Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin. | 2015 | Oncotarget | pmid:26397139 |
| Gao R et al. | Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. | 2015 | Biomed. Chromatogr. | pmid:25042239 |
| Long L et al. | Protective effects of scutellarin on type II diabetes mellitus-induced testicular damages related to reactive oxygen species/Bcl-2/Bax and reactive oxygen species/microcirculation/staving pathway in diabetic rat. | 2015 | J Diabetes Res | pmid:25861655 |
| Lin H et al. | A new and practical synthetic method for the synthesis of 6-O-methyl-scutellarein: one metabolite of scutellarin in vivo. | 2015 | Int J Mol Sci | pmid:25854429 |
| Qian S et al. | Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity. | 2015 | Viruses | pmid:25835532 |
| Kang I et al. | Effects of Mung Bean (Vigna radiata L.) Ethanol Extracts Decrease Proinflammatory Cytokine-Induced Lipogenesis in the KK-Ay Diabese Mouse Model. | 2015 | J Med Food | pmid:25826234 |
| Liu L et al. | Effect of luteolin and apigenin on the expression of Oct-4, Sox2, and c-Myc in dental pulp cells with in vitro culture. | 2015 | Biomed Res Int | pmid:25815323 |
| Nakamura K et al. | Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. | 2015 | Biol. Pharm. Bull. | pmid:25810454 |
| Mrazek AA et al. | Apigenin inhibits pancreatic stellate cell activity in pancreatitis. | 2015 | J. Surg. Res. | pmid:25799526 |
| Liu L et al. | Characterization of the intestinal absorption of seven flavonoids from the flowers of Trollius chinensis using the Caco-2 cell monolayer model. | 2015 | PLoS ONE | pmid:25789809 |
| Ji P et al. | Antiviral activity of Paulownia tomentosa against enterovirus 71 of hand, foot, and mouth disease. | 2015 | Biol. Pharm. Bull. | pmid:25744451 |
| Yuan Y et al. | Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia. | 2015 | J Neuroinflammation | pmid:25600517 |
| Li KC et al. | Apigenin-7-glycoside prevents LPS-induced acute lung injury via downregulation of oxidative enzyme expression and protein activation through inhibition of MAPK phosphorylation. | 2015 | Int J Mol Sci | pmid:25590301 |
| Huang H et al. | effects of natural flavonoids on photosynthetic activity and cell integrity in Microcystis aeruginosa. | 2015 | Toxins (Basel) | pmid:25584428 |
| Wright B et al. | GRID and docking analyses reveal a molecular basis for flavonoid inhibition of Src family kinase activity. | 2015 | J. Nutr. Biochem. | pmid:26140983 |
| Chang X et al. | Protective effect of apigenin on Freund's complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway. | 2015 | Chem. Biol. Interact. | pmid:25935278 |
| Yamagata K et al. | Dietary polyphenols regulate endothelial function and prevent cardiovascular disease. | 2015 | Nutrition | pmid:25466651 |
| Santos BL et al. | Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. | 2015 | Chem. Biol. Interact. | pmid:26408079 |
| Kim SH et al. | Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. | 2015 | Anticancer Res. | pmid:26637867 |
| Li H et al. | Separation of vitexin-4″-O-glucoside and vitexin-2″-O-rhamnoside from hawthorn leaves extracts using macroporous resins. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26562804 |
| Zemanova L et al. | Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment. | 2015 | J. Nat. Prod. | pmid:26529431 |
| Shi ZH et al. | Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. | 2015 | Eur J Med Chem | pmid:26523667 |
| Kang H et al. | Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo. | 2015 | Inflamm. Res. | pmid:26482935 |
| Bhardwaj M et al. | Potential role of vitexin in alleviating heat stress-induced cytotoxicity: Regulatory effect of Hsp90 on ER stress-mediated autophagy. | 2015 | Life Sci. | pmid:26475763 |
| Zhang X et al. | Stable knock-down of efflux transporters leads to reduced glucuronidation in UGT1A1-overexpressing HeLa cells: the evidence for glucuronidation-transport interplay. | 2015 | Mol. Pharm. | pmid:25741749 |
| Lee W et al. | Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo. | 2015 | Can. J. Physiol. Pharmacol. | pmid:26243020 |
| Bao YY et al. | Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo. | 2015 | Oncol. Rep. | pmid:26238658 |
| Long HP et al. | Involvenflavones A-F, six new flavonoids with 3'-aryl substituent from Selaginella involven. | 2015 | Fitoterapia | pmid:26226107 |
| Zhan YY et al. | Inhibitory Effect of Apigenin on Pharmacokinetics of Venlafaxine in vivo and in vitro. | 2015 | Pharmacology | pmid:26202346 |
| Min JW et al. | Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. | 2015 | Neuropharmacology | pmid:26187393 |
| Swanson HI et al. | Impact of apigenin and kaempferol on human head and neck squamous cell carcinoma. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:24439916 |
| Mirzoeva S et al. | Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism. | 2014 | Mol. Carcinog. | pmid:23359392 |
| Barlas N et al. | The estrogenic effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar albino rats. | 2014 | Toxicol. Lett. | pmid:24487097 |
| Zhang X et al. | Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25289789 |
| Kim KC et al. | Axl receptor tyrosine kinase is a novel target of apigenin for the inhibition of cell proliferation. | 2014 | Int. J. Mol. Med. | pmid:24926787 |
| Wang E et al. | Protective effects of apigenin against furan-induced toxicity in mice. | 2014 | Food Funct | pmid:24914499 |
| Caruso ÃP et al. | Binding of antioxidant flavone isovitexin to human serum albumin investigated by experimental and computational assays. | 2014 | J Pharm Biomed Anal | pmid:24905290 |
| Li LZ et al. | Flavonoids and other constituents from Aletris spicata and their chemotaxonomic significance. | 2014 | Nat. Prod. Res. | pmid:24896299 |
| Song HP et al. | Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC-MS combined with enzyme channel blocking. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24861872 |
| Zheng CJ et al. | Antiinflammatory effects and chemical constituents of Veronicastrum axillare. | 2014 | Phytother Res | pmid:24817590 |
| Chen J et al. | The apoptotic effect of apigenin on human gastric carcinoma cells through mitochondrial signal pathway. | 2014 | Tumour Biol. | pmid:24805829 |
| Tong X et al. | Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1. | 2014 | Oncotarget | pmid:25526033 |
| Xu H et al. | Antioxidative activities and active compounds of extracts from Catalpa plant leaves. | 2014 | ScientificWorldJournal | pmid:25431795 |
| Yuan Y et al. | Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia. | 2014 | BMC Neurosci | pmid:25416145 |
| Chelyn JL et al. | Analysis of flavone C-glycosides in the leaves of Clinacanthus nutans (Burm. f.) Lindau by HPTLC and HPLC-UV/DAD. | 2014 | ScientificWorldJournal | pmid:25405231 |
| Wang H et al. | Microwave-assisted simultaneous extraction of luteolin and apigenin from tree peony pod and evaluation of its antioxidant activity. | 2014 | ScientificWorldJournal | pmid:25405227 |
| Paramaguru R et al. | Antidiabetic activity of Pterospermum acerifolium flowers and glucose uptake potential of bioactive fraction in L6 muscle cell lines with its HPLC fingerprint. | 2014 | Biomed Res Int | pmid:25401101 |
| Zhang M et al. | Comparison of flavonoid compounds in the flavedo and juice of two pummelo cultivars (Citrus grandis L. Osbeck) from different cultivation regions in China. | 2014 | Molecules | pmid:25353383 |
| Lopez-Jornet P et al. | Effects of potassium apigenin and verbena extract on the wound healing process of SKH-1 mouse skin. | 2014 | Int Wound J | pmid:23136845 |
| Choi JS et al. | Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin. | 2014 | Food Chem. Toxicol. | pmid:24291393 |
| Wang JG et al. | Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma. | 2014 | Oncol. Rep. | pmid:24247909 |
| Shen LN et al. | Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes. | 2014 | Int J Pharm | pmid:24269286 |
| Liu LH et al. | Induction of apoptosis by VB1 in breast cancer cells: the role of reactive oxygen species and Bcl-2 family proteins. | 2014 | Int. J. Mol. Med. | pmid:24276280 |
| Sahreen S et al. | Comprehensive assessment of phenolics and antiradical potential of Rumex hastatus D. Don. roots. | 2014 | BMC Complement Altern Med | pmid:24507200 |
| Lakshmanan A et al. | Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells. | 2014 | Thyroid | pmid:24400871 |
| Liu Q et al. | Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis. | 2014 | J. Nat. Prod. | pmid:24955889 |
| Gouvea DR et al. | Evaluation of intestinal permeability of vicenin-2 and lychnopholic acid from Lychnophora salicifolia (Brazilian arnicão) using Caco-2 cells. | 2014 | J. Nat. Prod. | pmid:24279746 |
| You HS et al. | Influence of the gastrointestinal microflora and efflux transporters on the absorption of scutellarin and scutellarein. | 2014 | Phytother Res | pmid:24504668 |
| Kuo CH et al. | Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils. | 2014 | J Ethnopharmacol | pmid:24374236 |
| Tang H et al. | Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats. | 2014 | Pharmacol. Biochem. Behav. | pmid:24423938 |
| Zhang F et al. | Neuroprotective effect of apigenin in rats after contusive spinal cord injury. | 2014 | Neurol. Sci. | pmid:24166720 |
| Jin H et al. | Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II. | 2014 | Fitoterapia | pmid:24468190 |
| Pisonero-Vaquero S et al. | Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin. | 2014 | Lab. Invest. | pmid:24492281 |