| MeSH term | MeSH ID | Detail |
|---|---|---|
| Premature Birth | D047928 | 6 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Palmieri D et al. | Estrogen receptor activation protects against TNF-α-induced endothelial dysfunction. | 2014 | Angiology | pmid:23427281 |
| Swanson HI et al. | Impact of apigenin and kaempferol on human head and neck squamous cell carcinoma. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:24439916 |
| Mirzoeva S et al. | Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism. | 2014 | Mol. Carcinog. | pmid:23359392 |
| Zhang CJ et al. | [Simultaneous determination of four flavone C-glycosides in Phyllostachys edulis leaves by high-performance liquid chromatography with ultraviolet spectrometry]. | 2014 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:25532365 |
| Barlas N et al. | The estrogenic effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar albino rats. | 2014 | Toxicol. Lett. | pmid:24487097 |
| Zhang X et al. | Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25289789 |
| Chen T et al. | Preparation of two flavonoid glycosides with unique structures from barley seedlings by membrane separation technology and preparative high-performance liquid chromatography. | 2014 | J Sep Sci | pmid:25283274 |
| Wei Y et al. | Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles. | 2014 | Int J Pharm | pmid:25269007 |
| Jones MD et al. | Investigating sub-2 μm particle stationary phase supercritical fluid chromatography coupled to mass spectrometry for chemical profiling of chamomile extracts. | 2014 | Anal. Chim. Acta | pmid:25261902 |
| Cheng CY et al. | Inhibitory effects of scutellarein on proliferation of human lung cancer A549 cells through ERK and NFκB mediated by the EGFR pathway. | 2014 | Chin J Physiol | pmid:25246059 |
| Zargaran A et al. | Potential effect and mechanism of action of topical chamomile (Matricaria chammomila L.) oil on migraine headache: A medical hypothesis. | 2014 | Med. Hypotheses | pmid:25238714 |
| Seo KH et al. | Saponarin from barley sprouts inhibits NF-κB and MAPK on LPS-induced RAW 264.7 cells. | 2014 | Food Funct | pmid:25238253 |
| Guo H et al. | Apigenin mediated protection of OGD-evoked neuron-like injury in differentiated PC12 cells. | 2014 | Neurochem. Res. | pmid:25208641 |
| Wang D et al. | Scutellarin inhibits high glucose-induced and hypoxia-mimetic agent-induced angiogenic effects in human retinal endothelial cells through reactive oxygen species/hypoxia-inducible factor-1α/vascular endothelial growth factor pathway. | 2014 | J. Cardiovasc. Pharmacol. | pmid:25192544 |
| Yang X et al. | Nanosuspension development of scutellarein as an active and rapid orally absorbed precursor of its BCS class IV glycoside scutellarin. | 2014 | J Pharm Sci | pmid:25187229 |
| Watanabe Y et al. | Phytotoxic potential of Onopordum acanthium L. (Asteraceae). | 2014 | Chem. Biodivers. | pmid:25146768 |
| Fang L et al. | Application of isoabsorption plots generated by high-performance liquid chromatography with diode array detection to the development of multicomponent quantitative analysis of traditional herbal medicines. | 2014 | J Sep Sci | pmid:25146493 |
| Nisha VM et al. | Apigenin and quercetin ameliorate mitochondrial alterations by tunicamycin-induced ER stress in 3T3-L1 adipocytes. | 2014 | Appl. Biochem. Biotechnol. | pmid:25106896 |
| Patil SP et al. | Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice. | 2014 | Neuropharmacology | pmid:25087727 |
| Bhat G et al. | New phenolics from the root of Scutellaria prostrata JACQ. ex BENTH. | 2014 | Nat. Prod. Res. | pmid:25040064 |
| Khan HY et al. | Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action. | 2014 | Mol Nutr Food Res | pmid:24123728 |
| Song HP et al. | Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC-MS combined with enzyme channel blocking. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24861872 |
| Zheng CJ et al. | Antiinflammatory effects and chemical constituents of Veronicastrum axillare. | 2014 | Phytother Res | pmid:24817590 |
| Chen J et al. | The apoptotic effect of apigenin on human gastric carcinoma cells through mitochondrial signal pathway. | 2014 | Tumour Biol. | pmid:24805829 |
| Ali F et al. | Protective effect of apigenin against N-nitrosodiethylamine (NDEA)-induced hepatotoxicity in albino rats. | 2014 | Mutat Res Genet Toxicol Environ Mutagen | pmid:24755254 |
| Abd-Alla MH et al. | Rhizobium tibeticum activated with a mixture of flavonoids alleviates nickel toxicity in symbiosis with fenugreek (Trigonella foenum graecum L.). | 2014 | Ecotoxicology | pmid:24740320 |
| Islam MN et al. | Vicenin 2 isolated from Artemisia capillaris exhibited potent anti-glycation properties. | 2014 | Food Chem. Toxicol. | pmid:24713265 |
| Singh G et al. | Treatment of dermatophytosis by a new antifungal agent 'apigenin'. | 2014 | Mycoses | pmid:24708558 |
| Peng H et al. | Simultaneous separation of apigenin, luteolin and rosmarinic acid from the aerial parts of the copper-tolerant plant Elsholtzia splendens. | 2014 | Environ Sci Pollut Res Int | pmid:24671394 |
| Solmaz S et al. | Therapeutic potential of apigenin, a plant flavonoid, for imatinib-sensitive and resistant chronic myeloid leukemia cells. | 2014 | Nutr Cancer | pmid:24669768 |
| Li L et al. | Inhibition of human efflux transporter ABCC2 (MRP2) by self-emulsifying drug delivery system: influences of concentration and combination of excipients. | 2014 | J Pharm Pharm Sci | pmid:25579428 |
| Zheng X et al. | Synthesis and anti-cancer activities of apigenin derivatives. | 2014 | Med Chem | pmid:24605779 |
| Tong X et al. | Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1. | 2014 | Oncotarget | pmid:25526033 |
| Jung WW | Protective effect of apigenin against oxidative stress-induced damage in osteoblastic cells. | 2014 | Int. J. Mol. Med. | pmid:24573323 |
| Xu H et al. | Antioxidative activities and active compounds of extracts from Catalpa plant leaves. | 2014 | ScientificWorldJournal | pmid:25431795 |
| Xue HF et al. | Hepatic, gastric, and intestinal first-pass effects of vitexin in rats. | 2014 | Pharm Biol | pmid:24555505 |
| Simeonova R et al. | Protective effects of the apigenin-O/C-diglucoside saponarin from Gypsophila trichotoma on carbone tetrachloride-induced hepatotoxicity in vitro/in vivo in rats. | 2014 | Phytomedicine | pmid:24011529 |
| Yuan Y et al. | Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia. | 2014 | BMC Neurosci | pmid:25416145 |
| Wang F et al. | Host-guest inclusion system of scutellarein with 2-hydroxypropyl-beta-cyclodextrin: preparation, characterization, and anticancer activity. | 2014 | J Biomater Sci Polym Ed | pmid:24555409 |
| Chelyn JL et al. | Analysis of flavone C-glycosides in the leaves of Clinacanthus nutans (Burm. f.) Lindau by HPTLC and HPLC-UV/DAD. | 2014 | ScientificWorldJournal | pmid:25405231 |
| Wei W et al. | Effects of vitexin-2"-O-rhamnoside and vitexin-4"-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells. | 2014 | J. Pharm. Pharmacol. | pmid:24533889 |
| Wang H et al. | Microwave-assisted simultaneous extraction of luteolin and apigenin from tree peony pod and evaluation of its antioxidant activity. | 2014 | ScientificWorldJournal | pmid:25405227 |
| Kumar D and Bhat ZA | Apigenin 7-glucoside from Stachys tibetica Vatke and its anxiolytic effect in rats. | 2014 | Phytomedicine | pmid:24462214 |
| Paramaguru R et al. | Antidiabetic activity of Pterospermum acerifolium flowers and glucose uptake potential of bioactive fraction in L6 muscle cell lines with its HPLC fingerprint. | 2014 | Biomed Res Int | pmid:25401101 |
| Popović M et al. | The flavonoid apigenin delays forgetting of passive avoidance conditioning in rats. | 2014 | J. Psychopharmacol. (Oxford) | pmid:24284476 |
| Carbonneau MA et al. | Antioxidant properties of 3-deoxyanthocyanidins and polyphenolic extracts from Côte d'Ivoire's red and white sorghums assessed by ORAC and in vitro LDL oxidisability tests. | 2014 | Food Chem | pmid:24128534 |
| Zhang M et al. | Comparison of flavonoid compounds in the flavedo and juice of two pummelo cultivars (Citrus grandis L. Osbeck) from different cultivation regions in China. | 2014 | Molecules | pmid:25353383 |
| Choi JS et al. | Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin. | 2014 | Food Chem. Toxicol. | pmid:24291393 |
| Wang JG et al. | Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma. | 2014 | Oncol. Rep. | pmid:24247909 |
| Shen LN et al. | Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes. | 2014 | Int J Pharm | pmid:24269286 |
| Liu LH et al. | Induction of apoptosis by VB1 in breast cancer cells: the role of reactive oxygen species and Bcl-2 family proteins. | 2014 | Int. J. Mol. Med. | pmid:24276280 |
| Warat M et al. | Chrysin, apigenin and acacetin inhibit tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) on activated RAW264.7 macrophages. | 2014 | Int J Mol Sci | pmid:24979133 |
| Chen R et al. | Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells. | 2014 | Mol. Vis. | pmid:24623967 |
| Jiang NH et al. | Analysis of the transcriptome of Erigeron breviscapus uncovers putative scutellarin and chlorogenic acids biosynthetic genes and genetic markers. | 2014 | PLoS ONE | pmid:24956277 |
| Nakatsu D et al. | JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet. | 2014 | Genes Cells | pmid:24889144 |
| Ding SM et al. | Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion. | 2014 | Int J Nanomedicine | pmid:24872695 |
| Chen H et al. | Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo. | 2014 | Bioorg. Med. Chem. | pmid:24837156 |
| Paredes-Gonzalez X et al. | Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications. | 2014 | AAPS J | pmid:24830944 |
| Han YL et al. | In vitro inhibitory effects of scutellarin on six human/rat cytochrome P450 enzymes and P-glycoprotein. | 2014 | Molecules | pmid:24802986 |
| Michaelis M et al. | Karanjin interferes with ABCB1, ABCC1, and ABCG2. | 2014 | J Pharm Pharm Sci | pmid:24735762 |
| Liao Y et al. | Apigenin induces the apoptosis and regulates MAPK signaling pathways in mouse macrophage ANA-1 cells. | 2014 | PLoS ONE | pmid:24646936 |
| Sharma H et al. | Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells. | 2014 | PLoS ONE | pmid:24614817 |
| Silva DB et al. | Mass spectrometry of flavonoid vicenin-2, based sunlight barriers in Lychnophora species. | 2014 | Sci Rep | pmid:24603617 |
| Sahreen S et al. | Comprehensive assessment of phenolics and antiradical potential of Rumex hastatus D. Don. roots. | 2014 | BMC Complement Altern Med | pmid:24507200 |
| Lakshmanan A et al. | Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells. | 2014 | Thyroid | pmid:24400871 |
| Wu DG et al. | Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells. | 2014 | Toxicol. Lett. | pmid:24148603 |
| Han XJ et al. | Functional characterization of a Plagiochasma appendiculatum flavone synthase I showing flavanone 2-hydroxylase activity. | 2014 | FEBS Lett. | pmid:24859082 |
| Seo HS et al. | Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells. | 2014 | Anticancer Res. | pmid:24922650 |
| Lin Z et al. | In vivo effects of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 by cocktail probe drugs in rats. | 2014 | Pharmazie | pmid:25073400 |
| Shibata C et al. | The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels. | 2014 | Virology | pmid:25092460 |
| Zheng XX et al. | [Role of ERK/FoxO3a signal axis in inhibitory effect of vitexin 1 (VB-1) in HepG2 cell proliferation]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:25011268 |
| Moawad A et al. | Two new dihydroamentoflavone glycosides from Cycas revoluta. | 2014 | Nat. Prod. Res. | pmid:24404954 |
| Liu Q et al. | Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis. | 2014 | J. Nat. Prod. | pmid:24955889 |
| Gouvea DR et al. | Evaluation of intestinal permeability of vicenin-2 and lychnopholic acid from Lychnophora salicifolia (Brazilian arnicão) using Caco-2 cells. | 2014 | J. Nat. Prod. | pmid:24279746 |
| You HS et al. | Influence of the gastrointestinal microflora and efflux transporters on the absorption of scutellarin and scutellarein. | 2014 | Phytother Res | pmid:24504668 |
| Singh PP and Chauhan SM | Activity-guided isolation of antioxidants from the leaves of Terminalia arjuna. | 2014 | Nat. Prod. Res. | pmid:24484080 |
| Kuo CH et al. | Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils. | 2014 | J Ethnopharmacol | pmid:24374236 |
| Je HG et al. | The inhibitory effect of vitexin on the agonist-induced regulation of vascular contractility. | 2014 | Pharmazie | pmid:24716414 |
| Vázquez JA | Modeling of chemical inhibition from amyloid protein aggregation kinetics. | 2014 | BMC Pharmacol Toxicol | pmid:24572069 |
| Kim MA et al. | Apigenin isolated from Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion. | 2014 | Life Sci. | pmid:24582594 |
| Li YR et al. | [Quality standard study on Vigna radiata]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:24754176 |
| Lee Y et al. | Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells. | 2014 | Int. J. Oncol. | pmid:24626522 |
| Shukla S et al. | Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer. | 2014 | Apoptosis | pmid:24563225 |
| Harrison ME et al. | Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt. | 2014 | Exp. Mol. Pathol. | pmid:25019465 |
| Tang H et al. | Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats. | 2014 | Pharmacol. Biochem. Behav. | pmid:24423938 |
| Zhang F et al. | Neuroprotective effect of apigenin in rats after contusive spinal cord injury. | 2014 | Neurol. Sci. | pmid:24166720 |
| Jin H et al. | Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II. | 2014 | Fitoterapia | pmid:24468190 |
| Guedj F et al. | Prenatal treatment of Down syndrome: a reality? | 2014 | Curr. Opin. Obstet. Gynecol. | pmid:24573065 |
| Pisonero-Vaquero S et al. | Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin. | 2014 | Lab. Invest. | pmid:24492281 |
| Ross SM | Generalized anxiety disorder (GAD): efficacy of standardized Matricaria recutita (German chamomile) extract in the treatment of generalized anxiety disorder. | 2013 Nov-Dec | Holist Nurs Pract | pmid:24121702 |
| Lu CC et al. | Vitexin protects against cardiac hypertrophy via inhibiting calcineurin and CaMKII signaling pathways. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23624753 |
| Dong J et al. | Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin. | 2013 | FEMS Microbiol. Lett. | pmid:23113475 |
| Li J and Yu DQ | Two new constituents from Erigeron breviscapus. | 2013 | J Asian Nat Prod Res | pmid:24073637 |
| Li YL et al. | [Evaluation on preparation process of brevisapin colon-specific tables and its in vitro release]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23717958 |
| Das S et al. | Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro. | 2013 | Toxicol. Lett. | pmid:24070738 |
| Guimarães R et al. | Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations. | 2013 | Food Chem | pmid:23122119 |
| Dağdelen A et al. | Phenolics profiles of olive fruits (Olea europaea L.) and oils from Ayvalık, Domat and Gemlik varieties at different ripening stages. | 2013 | Food Chem | pmid:23017390 |
| Liu XY et al. | The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. | 2013 | Biomed Res Int | pmid:24369535 |
| Yuan M et al. | Contribution evaluation of the floral parts to orientin and vitexin concentrations in the flowers of Trollius chinensis. | 2013 | Chin J Nat Med | pmid:24345513 |
| Yan C et al. | Simultaneous determination of vitexin and isovitexin in rat plasma after oral administration of Santalum album L. leaves extract by liquid chromatography tandem mass spectrometry. | 2013 | Biomed. Chromatogr. | pmid:22706896 |