| MeSH term | MeSH ID | Detail |
|---|---|---|
| Premature Birth | D047928 | 6 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ye Q et al. | Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion. | 2013 | J. Mol. Biol. | pmid:23238254 |
| Praveena R et al. | Experimental and DFT studies on the antioxidant activity of a C-glycoside from Rhynchosia capitata. | 2013 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:23246319 |
| Li L et al. | Effects of spray-drying and choice of solid carriers on concentrations of Labrasol® and Transcutol® in solid self-microemulsifying drug delivery systems (SMEDDS). | 2013 | Molecules | pmid:23282540 |
| Falé PL et al. | Effect of luteolin and apigenin on rosmarinic acid bioavailability in Caco-2 cell monolayers. | 2013 | Food Funct | pmid:23223784 |
| Kim EY et al. | Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through ERK-dependent up-regulation of TRAIL receptor DR5. | 2013 | Mol. Cells | pmid:23224239 |
| Horibe I et al. | Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells. | 2013 | J Nat Med | pmid:23208771 |
| Tong X and Pelling JC | Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention. | 2013 | Anticancer Agents Med Chem | pmid:23272913 |
| Lampropoulos P et al. | The role of apigenin in an experimental model of acute pancreatitis. | 2013 | J. Surg. Res. | pmid:23273883 |
| Wang YC and Huang KM | In vitro anti-inflammatory effect of apigenin in the Helicobacter pylori-infected gastric adenocarcinoma cells. | 2013 | Food Chem. Toxicol. | pmid:23266501 |
| Pawlikowska-Pawlęga B et al. | FTIR, (1)H NMR and EPR spectroscopy studies on the interaction of flavone apigenin with dipalmitoylphosphatidylcholine liposomes. | 2013 | Biochim. Biophys. Acta | pmid:23088916 |
| Awaad AS et al. | Antiulcerogenic activities of the extracts and isolated flavonoids of Euphorbia cuneata Vahl. | 2013 | Phytother Res | pmid:23097351 |
| Can ÖD et al. | Anti-depressant-like effect of vitexin in BALB/c mice and evidence for the involvement of monoaminergic mechanisms. | 2013 | Eur. J. Pharmacol. | pmid:23099258 |
| Narwal M et al. | Screening and structural analysis of flavones inhibiting tankyrases. | 2013 | J. Med. Chem. | pmid:23574272 |
| Pandith H et al. | Effect of Siam weed extract and its bioactive component scutellarein tetramethyl ether on anti-inflammatory activity through NF-κB pathway. | 2013 | J Ethnopharmacol | pmid:23535395 |
| Li H et al. | Potentiation of scutellarin on human tongue carcinoma xenograft by low-intensity ultrasound. | 2013 | PLoS ONE | pmid:23536878 |
| Wiejak J et al. | Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. | 2013 | Biochem. J. | pmid:23782265 |
| Wu DW et al. | Inactivation of jack bean urease by scutellarin: elucidation of inhibitory efficacy, kinetics and mechanism. | 2013 | Fitoterapia | pmid:23978581 |
| Bao YY et al. | Anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers. | 2013 | Future Oncol | pmid:23980682 |
| Zhou J et al. | Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway. | 2013 | Anticancer Drugs | pmid:23965728 |
| Zhao L et al. | Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer's disease mouse model. | 2013 | Molecules | pmid:23966081 |
| Maggioni D et al. | Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis. | 2013 | Int. J. Oncol. | pmid:23969487 |
| Li Y et al. | Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. | 2013 | Environ. Health Perspect. | pmid:23384675 |
| Spoerlein C et al. | Effects of chrysin, apigenin, genistein and their homoleptic copper(II) complexes on the growth and metastatic potential of cancer cells. | 2013 | J. Inorg. Biochem. | pmid:23973682 |
| Iizumi Y et al. | The flavonoid apigenin downregulates CDK1 by directly targeting ribosomal protein S9. | 2013 | PLoS ONE | pmid:24009741 |
| Hasegawa E et al. | Effect of polyphenols on production of steroid hormones from human adrenocortical NCI-H295R cells. | 2013 | Biol. Pharm. Bull. | pmid:23370353 |
| Chai L et al. | Scutellarin and caffeic acid ester fraction, active components of Dengzhanxixin injection, upregulate neurotrophins synthesis and release in hypoxia/reoxygenation rat astrocytes. | 2013 | J Ethnopharmacol | pmid:24012966 |
| Alcaraz M et al. | Effects of bisphosphonates in combination with ionizing radiation and antioxidants on the growth of prostate and melanoma cells lines. | 2013 | Anticancer Res. | pmid:23898082 |
| Das S et al. | Apigenin, a bioactive flavonoid from Lycopodium clavatum, stimulates nucleotide excision repair genes to protect skin keratinocytes from ultraviolet B-induced reactive oxygen species and DNA damage. | 2013 | J Acupunct Meridian Stud | pmid:24139463 |
| Wang Y et al. | Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro. | 2013 | Chem. Biol. Interact. | pmid:24144774 |
| Kim SH et al. | Akt inhibition enhances the cytotoxic effect of apigenin in combination with PLX4032 in anaplastic thyroid carcinoma cells harboring BRAFV600E. | 2013 | J. Endocrinol. Invest. | pmid:24084189 |
| Chen X et al. | Scutellarin attenuates hypertension-induced expression of brain Toll-like receptor 4/nuclear factor kappa B. | 2013 | Mediators Inflamm. | pmid:24223475 |
| Zhang XF et al. | The effect of the skeleton structure of flavanone and flavonoid on interaction with transferrin. | 2013 | Bioorg. Med. Chem. Lett. | pmid:24239187 |
| Ding B et al. | Preparation and in vitro evaluation of apigenin loaded lipid nanocapsules. | 2013 | J Nanosci Nanotechnol | pmid:24245113 |
| Shao H et al. | Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263. | 2013 | Mol. Cancer Ther. | pmid:24126433 |
| Mafuvadze B et al. | Effects of dietary apigenin on tumor latency, incidence and multiplicity in a medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced breast cancer model. | 2013 | Nutr Cancer | pmid:24127693 |
| Guo LL et al. | The neurotoxicity of β-amyloid peptide toward rat brain is associated with enhanced oxidative stress, inflammation and apoptosis, all of which can be attenuated by scutellarin. | 2013 | Exp. Toxicol. Pathol. | pmid:22739358 |
| Huang CS et al. | Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes. | 2013 | Arch. Toxicol. | pmid:22864849 |
| Patanayindee J et al. | Antidiarrheal efficacy of a quinazolin CFTR inhibitor on human intestinal epithelial cell and in mouse model of cholera. | 2012 Sep-Oct | Indian J Pharmacol | pmid:23112425 |
| Amsterdam JD et al. | Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study. | 2012 Sep-Oct | Altern Ther Health Med | pmid:22894890 |
| Bertelli D et al. | ¹H-NMR simultaneous identification of health-relevant compounds in propolis extracts. | 2012 May-Jun | Phytochem Anal | pmid:21853496 |
| He B et al. | [A new method of calibration and positioning in quantitative analysis of multicomponents by single marker]. | 2012 | Yao Xue Xue Bao | pmid:23460972 |
| Das S et al. | Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria. | 2012 | Exp. Biol. Med. (Maywood) | pmid:23354402 |
| D'Orazio N et al. | Marine bioactives: pharmacological properties and potential applications against inflammatory diseases. | 2012 | Mar Drugs | pmid:22690145 |
| Riaz N et al. | Lipoxygenase inhibitory sphingolipids from Launaea nudicaulis. | 2012 | J Asian Nat Prod Res | pmid:22587795 |
| Toh MF et al. | Biological characterization of non-steroidal progestins from botanicals used for women's health. | 2012 | Steroids | pmid:22484153 |
| Makino T et al. | Biocatalytic synthesis of flavones and hydroxyl-small molecules by recombinant Escherichia coli cells expressing the cyanobacterial CYP110E1 gene. | 2012 | Microb. Cell Fact. | pmid:22809492 |
| de Souza MR et al. | Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents. | 2012 | J Ethnopharmacol | pmid:22732730 |
| Liu R et al. | Nitrogen-containing apigenin analogs: preparation and biological activity. | 2012 | Molecules | pmid:23519250 |
| Wang HC et al. | Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90. | 2012 | PLoS ONE | pmid:22701533 |
| Lee CC et al. | Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway. | 2012 | Evid Based Complement Alternat Med | pmid:22701509 |
| Brito SA et al. | Evaluation of the antifungal activity and modulation between Cajanus cajan (L.) Millsp. leaves and roots ethanolic extracts and conventional antifungals. | 2012 | Pharmacogn Mag | pmid:22701281 |
| Nugroho AE et al. | Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats. | 2012 | Indian J Pharmacol | pmid:22701250 |
| Tai ZF et al. | Identification of small molecule activators of the janus kinase/signal transducer and activator of transcription pathway using a cell-based screen. | 2012 | Biol. Pharm. Bull. | pmid:22223339 |
| Waki T et al. | Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives. | 2012 | Chem. Pharm. Bull. | pmid:22223373 |
| Jiang Y et al. | Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin. | 2012 | EMBO J. | pmid:22491013 |
| Li J et al. | Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. | 2012 | J. Nat. Prod. | pmid:22475308 |
| Adnani N et al. | Universal quantification of structurally diverse natural products using an evaporative light scattering detector. | 2012 | J. Nat. Prod. | pmid:22471612 |
| Teng Z et al. | Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells. | 2012 | PLoS ONE | pmid:22253753 |
| Tang LI et al. | Screening of anti-dengue activity in methanolic extracts of medicinal plants. | 2012 | BMC Complement Altern Med | pmid:22244370 |
| Williams G | A searchable cross-platform gene expression database reveals connections between drug treatments and disease. | 2012 | BMC Genomics | pmid:22233519 |
| Loizzo MR et al. | Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities. | 2012 | J. Sci. Food Agric. | pmid:22589172 |
| Zhu M et al. | Relationship between the composition of flavonoids and flower colors variation in tropical water lily (Nymphaea) cultivars. | 2012 | PLoS ONE | pmid:22485167 |
| Liu YH et al. | Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal Cancer Cell Growth and Metastasis. | 2012 | Evid Based Complement Alternat Med | pmid:22028734 |
| Zhao XN et al. | Spectroscopic studies on the interaction of bovine serum albumin with surfactants and apigenin. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22561754 |
| Mafuvadze B et al. | Apigenin induces apoptosis and blocks growth of medroxyprogesterone acetate-dependent BT-474 xenograft tumors. | 2012 | Horm Cancer | pmid:22569706 |
| Lamy S et al. | Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway. | 2012 | Exp. Cell Res. | pmid:22522122 |
| Wang Y et al. | Evaluating cell migration in vitro by the method based on cell patterning within microfluidic channels. | 2012 | Electrophoresis | pmid:22522534 |
| Wang J et al. | Apigenin inhibits the expression of IL-6, IL-8, and ICAM-1 in DEHP-stimulated human umbilical vein endothelial cells and in vivo. | 2012 | Inflammation | pmid:22527144 |
| Seo HS et al. | Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells. | 2012 | Mol. Cell. Biochem. | pmid:22527937 |
| Feng Y et al. | Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells. | 2012 | Leuk. Lymphoma | pmid:22582896 |
| Forgo P et al. | Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L. | 2012 | Fitoterapia | pmid:22537643 |
| MartÃnez-Vázquez M et al. | Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: sedative effect and chemical analysis of an aqueous extract. | 2012 | J Ethnopharmacol | pmid:22469767 |
| Liao YF et al. | Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells. | 2012 | Food Chem. Toxicol. | pmid:22634262 |
| Engelbertz J et al. | Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect. | 2012 | J Ethnopharmacol | pmid:22465593 |
| Yu MS et al. | Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22578462 |
| Kil JS et al. | Okanin, a chalcone found in the genus Bidens, and 3-penten-2-one inhibit inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with lipopolysaccharide. | 2012 | J Clin Biochem Nutr | pmid:22247601 |
| Gazzani G et al. | Food components with anticaries activity. | 2012 | Curr. Opin. Biotechnol. | pmid:22030309 |
| Rithidech KN et al. | Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation. | 2012 | Mutat. Res. | pmid:23010607 |
| An YT et al. | A neuroprotective mechanism of YGY-E in cerebral ischemic injury in rats. | 2012 | CNS Neurosci Ther | pmid:22280158 |
| Dixit D et al. | Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition. | 2012 | Cell Death Dis | pmid:22318540 |
| Zhang L et al. | Two new flavonoid glycosides from Semen Ziziphi Spinosae. | 2012 | J Asian Nat Prod Res | pmid:22296152 |
| Ghanbari R et al. | Valuable nutrients and functional bioactives in different parts of olive (Olea europaea L.)-a review. | 2012 | Int J Mol Sci | pmid:22489153 |
| Lee CY et al. | Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway. | 2012 | Oncol. Rep. | pmid:22941432 |
| Gadi D et al. | Flavonoids purified from parsley inhibit human blood platelet aggregation and adhesion to collagen under flow. | 2012 | J Complement Integr Med | pmid:22944717 |
| Sun XY et al. | [Chemical constituents of Trichosanthes kirilowii Maxim]. | 2012 | Yao Xue Xue Bao | pmid:22993858 |
| Liu Y et al. | Effects of the natural flavone trimethylapigenin on cardiac potassium currents. | 2012 | Biochem. Pharmacol. | pmid:22583923 |
| Çelik H and Koşar M | Inhibitory effects of dietary flavonoids on purified hepatic NADH-cytochrome b5 reductase: structure-activity relationships. | 2012 | Chem. Biol. Interact. | pmid:22542668 |
| Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
| Ganugapati J et al. | Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus. | 2012 | Bioinformation | pmid:22493522 |
| Cesca TG et al. | Antinociceptive, anti-inflammatory and wound healing features in animal models treated with a semisolid herbal medicine based on Aleurites moluccana L. Willd. Euforbiaceae standardized leaf extract: semisolid herbal. | 2012 | J Ethnopharmacol | pmid:22776834 |
| Pinheiro MM et al. | Antinociceptive effect of the Orbignya speciosa Mart. (Babassu) leaves: evidence for the involvement of apigenin. | 2012 | Life Sci. | pmid:22749864 |
| Frank JH et al. | Variable-temperature ¹H-NMR studies on two C-glycosylflavones. | 2012 | Molecules | pmid:22751258 |
| Ramallo IA et al. | Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis. | 2012 | Med Chem | pmid:22420559 |
| Weng Z et al. | Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. | 2012 | PLoS ONE | pmid:22470478 |
| Su Y et al. | Scutellarin inhibits translocation of protein kinase C in diabetic thoracic aorta of the rat. | 2012 | Clin. Exp. Pharmacol. Physiol. | pmid:22092277 |
| Guan H et al. | Apigenin attenuates neointima formation via suppression of vascular smooth muscle cell phenotypic transformation. | 2012 | J. Cell. Biochem. | pmid:22095643 |
| Ma X et al. | Apigenin, a plant-derived flavone, activates transient receptor potential vanilloid 4 cation channel. | 2012 | Br. J. Pharmacol. | pmid:22049911 |
| Hanqing C et al. | Research on scutellarin parenteral solution's protective effects in rats with severe acute pancreatitis and multiple organ injuries. | 2012 | Inflammation | pmid:22105928 |
| Azimi H et al. | A review of animal and human studies for management of benign prostatic hyperplasia with natural products: perspective of new pharmacological agents. | 2012 | Inflamm Allergy Drug Targets | pmid:22512478 |
| Pham H et al. | Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells. | 2012 | Pancreas | pmid:22889981 |