MeSH term | MeSH ID | Detail |
---|---|---|
Astrocytoma | D001254 | 15 associated lipids |
Asthma | D001249 | 52 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
MeSH term | MeSH ID | Detail |
---|---|---|
Astrocytoma | D001254 | 15 associated lipids |
Asthma | D001249 | 52 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhu F et al. | [Effect of emodin and apigenin on invasion of human ovarian carcinoma HO-8910PM cells in vitro]. | 2003 | Ai Zheng | pmid:12703988 |
Chang H et al. | [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60]. | 2007 | Ai Zheng | pmid:18076792 |
Critchfield JW et al. | Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8825617 |
Kawai M et al. | Flavonoids and related compounds as anti-allergic substances. | 2007 | Allergol Int | pmid:17384531 |
Amsterdam JD et al. | Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study. | 2012 Sep-Oct | Altern Ther Health Med | pmid:22894890 |
Brantner AH et al. | HET-CAM bioassay as in vitro alternative to the croton oil test for investigating steroidal and non-steroidal compounds. | 2002 | ALTEX | pmid:12098009 |
Chledzik S et al. | Pharmacological Effects of Scutellarin, An Active Component of Genus Scutellaria and Erigeron: A Systematic Review. | 2018 | Am. J. Chin. Med. | pmid:29433387 |
Tsai JC et al. | Hepatoprotective effect of Scoparia dulcis on carbon tetrachloride induced acute liver injury in mice. | 2010 | Am. J. Chin. Med. | pmid:20626061 |
Jiang DP et al. | Scutellarin attenuates human-neutrophil-elastase-induced mucus production by inhibiting the PKC-ERK signaling pathway in vitro and in vivo. | 2011 | Am. J. Chin. Med. | pmid:22083990 |
Shin JW et al. | Scutellarin Ameliorates Learning and Memory Deficit via Suppressing [Formula: see text]-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion. | 2018 | Am. J. Chin. Med. | pmid:30149759 |