| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu M et al. | An acylated flavone C-glycoside from Glycyrrhiza eurycarpa. | 1994 | Phytochemistry | pmid:7765208 |
| Toki K et al. | (Delphinidin 3-gentiobiosyl) (apigenin 7-glucosyl) malonate from the flowers of Eichhornia crassipes. | 1994 | Phytochemistry | pmid:7765361 |
| Hertog MG et al. | Dietary flavonoids and cancer risk in the Zutphen Elderly Study. | 1994 | Nutr Cancer | pmid:14502846 |
| Green MD et al. | Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. | 1994 Sep-Oct | Drug Metab. Dispos. | pmid:7835232 |
| Schüssler M et al. | Functional and antiischaemic effects of Monoacetyl-vitexinrhamnoside in different in vitro models. | 1995 | Gen. Pharmacol. | pmid:8690247 |
| Venturella P et al. | Three acylated flavone glycosides from Sideritis syriaca. | 1995 | Phytochemistry | pmid:7772308 |
| Gaitan E et al. | Antithyroid effects in vivo and in vitro of vitexin: a C-glucosylflavone in millet. | 1995 | J. Clin. Endocrinol. Metab. | pmid:7714083 |
| Green MD et al. | Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. | 1995 | Arch. Biochem. Biophys. | pmid:7574722 |
| Critchfield JW et al. | Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8825617 |
| Lyckander IM and Malterud KE | Lipophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lipoxygenase. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804120 |
| Akama T et al. | Novel 5-aminoflavone derivatives as specific antitumor agents in breast cancer. | 1996 | J. Med. Chem. | pmid:8784443 |
| Palomino OM et al. | Isoscutellarein 7-glucosyl(1-->2)xyloside from sixteen species of Sideritis. | 1996 | Phytochemistry | pmid:8728059 |
| Aida Y et al. | Synthesis of 7-methoxyapigeninidin and its fungicidal activity against Gloeocercospora sorghi. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8987602 |
| Lin YM et al. | In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora. | 1997 | J. Nat. Prod. | pmid:9322359 |
| Shen YX et al. | [Studies on the flavonoids from Dendranthema lavandulifolium]. | 1997 | Yao Xue Xue Bao | pmid:11596327 |
| Bylka W and Matławska I | Flavonoids from Aquilegia vulgaris L. Part II. Derivatives of apigenin and luteolin. | 1997 Jul-Aug | Acta Pol Pharm | pmid:9511462 |
| Kitsos CM and Stadtländer CT | Helicobacter pylori in liquid culture: evaluation of growth rates and ultrastructure. | 1998 | Curr. Microbiol. | pmid:9705648 |
| Kuiper GG et al. | Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. | 1998 | Endocrinology | pmid:9751507 |
| Chen S et al. | [Studies on flavonoids from Aquilegia oxysepala Trautv. et Mey]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12242797 |
| Galijatovic A et al. | Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. | 1999 | Xenobiotica | pmid:10647910 |
| Wang IK et al. | Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. | 1999 | Eur. J. Cancer | pmid:10673981 |
| Kawai K et al. | Clerodendrin I, a New Neoclerodane Diterpenoid from Clerodendron trichotomum. | 1999 | Biosci. Biotechnol. Biochem. | pmid:26300171 |
| Aljancić I et al. | Flavones and sesquiterpene lactones from Achillea atrata subsp. multifida: antimicrobial activity. | 1999 | J. Nat. Prod. | pmid:10395518 |
| Jeong HJ et al. | Inhibition of aromatase activity by flavonoids. | 1999 | Arch. Pharm. Res. | pmid:10403137 |
| Dekermendjian K et al. | Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex. | 1999 | J. Med. Chem. | pmid:10543878 |
| Afifi FU et al. | Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs. | 1999 | J Ethnopharmacol | pmid:10465658 |
| Takasaki M et al. | Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens. | 1999 | J. Nat. Prod. | pmid:10425119 |
| Uma Devi P et al. | In vivo radioprotection by ocimum flavonoids: survival of mice. | 1999 | Radiat. Res. | pmid:9973087 |
| Breinholt V et al. | Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. | 1999 | Xenobiotica | pmid:10647909 |
| Al-Okla S et al. | Involvement of alpha5beta1 integrins in interleukin 8 production induced by oral viridans streptococcal protein I/IIf in cultured endothelial cells. | 1999 | Cell. Microbiol. | pmid:11207549 |
| Yin F et al. | Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). | 1999 Sep-Oct | Anticancer Res. | pmid:10628390 |
| Sang SM et al. | [Studies on the flavonol glycosides from the seeds of Vaccaria segetalis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512436 |
| Zhang WD et al. | [Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516462 |
| Zhang J et al. | [Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516463 |
| Song DH et al. | Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. | 2000 | J. Biol. Chem. | pmid:10806215 |
| O'Gorman DM et al. | Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals. | 2000 | Leukemia | pmid:10764145 |
| Bible KC et al. | Flavopiridol binds to duplex DNA. | 2000 | Cancer Res. | pmid:10811119 |
| Zanoli P et al. | Behavioral characterisation of the flavonoids apigenin and chrysin. | 2000 | Fitoterapia | pmid:10930722 |
| Trochon V et al. | Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression. | 2000 | Int. J. Cancer | pmid:10699950 |
| Nakazawa T and Ohsawa K | Metabolites of orally administered Perilla frutescens extract in rats and humans. | 2000 | Biol. Pharm. Bull. | pmid:10706426 |
| Hiremath SP et al. | Antifertility and hormonal properties of flavones of Striga orobanchioides. | 2000 | Eur. J. Pharmacol. | pmid:10720651 |
| Caltagirone S et al. | Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. | 2000 | Int. J. Cancer | pmid:10918203 |
| Romanová D et al. | Determination of apigenin in rat plasma by high-performance liquid chromatography. | 2000 | J Chromatogr A | pmid:10722103 |
| Pieroni A and Pachaly P | Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L. | 2000 | Pharmazie | pmid:10683879 |
| de Santi C et al. | Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. | 2000 | Xenobiotica | pmid:11197066 |
| Iwashita K et al. | Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11055382 |
| Breinholt V et al. | Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. | 2000 | Food Chem. Toxicol. | pmid:10942316 |
| Ashida H | Suppressive effects of flavonoids on dioxin toxicity. | 2000 | Biofactors | pmid:11216487 |
| Tatsuta A et al. | Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. | 2000 | Clin. Exp. Metastasis | pmid:11827069 |
| De Santi C et al. | Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. | 2000 | Xenobiotica | pmid:11055264 |