apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Brain Ischemia D002545 89 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Astrocytoma D001254 15 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

Download all related citations
Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Wang XM et al. [HPLC determination of four active components in dengzhanxixin injection]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18841764
Hua Y and Wang HQ [Studies on the flavonoids from whole herbs of Seriphidium terrae-albae]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17048665
Han SL et al. [Comparison of antioxidant activity between two species of chamomiles produced in Xinjiang by TLC-bioautography]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23672040
Ren DC et al. [Chemical study on aerial parts of Ligusticum chuanxiong]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17966355
Tong C and Wu X [Determination of plasma protein binding rate of vitexin]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23126208
Yang HP et al. [Studies on glycosides from Gentiana veitchiorum]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19149260
Wu X et al. [Studies on flavones in of Lavandula augustifolia]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17639984
Zhang S et al. [Studies on chemical constituents of Eriophyton wallichii]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17639985
Zhang Y et al. [Effect of caffeic acid, seopoletin and scutellarin on rat retinal neurons in vitro]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16124607
Wang M et al. [Studies on constituents of Dendrobium gratiosissimum]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17608224
Che QM et al. [Study on bile excretion of scutellarein]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17225543
Dong Q et al. [Studies on chemical constituents from stellaria media. I]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17672340
Hu BB et al. [Determination of main flavone glycosides in Flos Chrysanthemi and observation of factors influenced contents]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17260789
Liu J and Xiong Y [Advances in studies on pharmacokinetics of scutellarin and scutellarein]. 2009 Zhongguo Zhong Yao Za Zhi pmid:20352990
Dawa ZM et al. [Studies on chemical constituents of Saussurea laniceps]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18652351
Qu L et al. [Determination of vitexin-rhamnoside in Beagle dog plasma and preliminary pharmacokinetics of Yixintong sustained release tablets]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18720869
Cheng YB et al. [Study on chemical constituents in rhizome of Smilax perfoliate]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15015307
Zhu LW et al. [Pharmacokinetics of scutellarin and its derivant scutellarin ethyl ester in rats]. 2013 Zhongguo Zhong Yao Za Zhi pmid:24422411
Huang Y et al. [Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound hongcao for injection by UPLC-MS/MS]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22375405
Zhao DB et al. [Studies on chemical constituents in herb of Chondrilla piptocoma]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011281
Shi T et al. [Effect of apigenin on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis]. 2015 Zhonghua Gan Zang Bing Za Zhi pmid:25880979
Shi XR et al. [Apigenin affects semen parameters in male mice]. 2010 Zhonghua Nan Ke Xue pmid:21171258
Yao HM et al. [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. 2017 Zhonghua Xin Xue Guan Bing Za Zhi pmid:28545285
Xing Y et al. [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation]. 2002 Zhonghua Yi Xue Za Zhi pmid:12509912
Wang LY et al. [Apigenin regulates lipopolysaccharides-induced activation of inflammasome]. 2011 Zhonghua Yi Xue Za Zhi pmid:22321793
Jin XY and Ren CS [Effect and mechanism of apigenin on VEGF expression in human breast cancer cells]. 2007 Zhonghua Zhong Liu Za Zhi pmid:18069627
Tatemoto H et al. Inhibition of boar sperm hyaluronidase activity by tannic acid reduces polyspermy during in vitro fertilization of porcine oocytes. 2006 Zygote pmid:17266786