| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colitis | D003092 | 69 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yin F et al. | Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). | 1999 Sep-Oct | Anticancer Res. | pmid:10628390 |
| Alcaraz M et al. | Effects of bisphosphonates in combination with ionizing radiation and antioxidants on the growth of prostate and melanoma cells lines. | 2013 | Anticancer Res. | pmid:23898082 |
| Seo HS et al. | Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells. | 2014 | Anticancer Res. | pmid:24922650 |
| Yin F et al. | Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. | 2001 Jan-Feb | Anticancer Res. | pmid:11299771 |
| Koo H et al. | Influence of apigenin on gtf gene expression in Streptococcus mutans UA159. | 2006 | Antimicrob. Agents Chemother. | pmid:16436708 |
| Wong IL et al. | Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania. | 2007 | Antimicrob. Agents Chemother. | pmid:17194831 |
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| Nagai T et al. | In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase. | 1992 | Antiviral Res. | pmid:1444327 |
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| Shukla S et al. | Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer. | 2014 | Apoptosis | pmid:24563225 |
| Bhandari D et al. | Dual function surface-enhanced Raman active extractor for the detection of environmental contaminants. | 2009 | Appl Spectrosc | pmid:19470216 |
| Nisha VM et al. | Apigenin and quercetin ameliorate mitochondrial alterations by tunicamycin-induced ER stress in 3T3-L1 adipocytes. | 2014 | Appl. Biochem. Biotechnol. | pmid:25106896 |
| Bai Y et al. | Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications. | 2017 | Appl. Biochem. Biotechnol. | pmid:27933483 |
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| Chen L et al. | Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. | 2017 | Arch Gerontol Geriatr | pmid:28743056 |
| SEIKEL MK and GEISSMAN TA | The flavonoid constituents of barley (Horedum vulgare). I. Saponarin. | 1957 | Arch. Biochem. Biophys. | pmid:13459424 |
| Miro FA et al. | Persistent nuclear accumulation of protein kinase CK2 during the G1-phase of the cell cycle does not depend on the ERK1/2 pathway but requires active protein synthesis. | 2002 | Arch. Biochem. Biophys. | pmid:12361704 |
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| Kanazawa K et al. | Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells. | 2006 | Arch. Biochem. Biophys. | pmid:17052680 |
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| Green MD et al. | Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. | 1995 | Arch. Biochem. Biophys. | pmid:7574722 |
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| Huh S et al. | A cell-based system for screening hair growth-promoting agents. | 2009 | Arch. Dermatol. Res. | pmid:19277688 |
| Majtan J et al. | Fir honeydew honey flavonoids inhibit TNF-α-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing. | 2013 | Arch. Dermatol. Res. | pmid:23812412 |
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| Ketkaew Y et al. | Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. | 2017 | Arch. Oral Biol. | pmid:27886571 |
| Silvan S and Manoharan S | Apigenin prevents deregulation in the expression pattern of cell-proliferative, apoptotic, inflammatory and angiogenic markers during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. | 2013 | Arch. Oral Biol. | pmid:22776109 |
| Lyu SY and Park WB | Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. | 2005 | Arch. Pharm. Res. | pmid:15974445 |
| Yee SB et al. | Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells. | 2003 | Arch. Pharm. Res. | pmid:12643593 |
| Tang H et al. | Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques. | 2015 | Arch. Pharm. Res. | pmid:25577334 |
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| Lee S et al. | Phytochemical constituents from the herba of Artemisia apiacea. | 2002 | Arch. Pharm. Res. | pmid:12135098 |
| Sim GS et al. | Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. | 2007 | Arch. Pharm. Res. | pmid:17424933 |
| Myoung HJ et al. | Apigenin isolated from the seeds of Perilla frutescens britton var crispa (Benth.) inhibits food intake in C57BL/6J mice. | 2010 | Arch. Pharm. Res. | pmid:21116776 |
| Gutiérrez-Venegas G and González-Rosas Z | Apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells. | 2017 | Arch. Pharm. Res. | pmid:27193174 |
| Jang DS et al. | Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on advanced glycation end products and rat lens aldose reductase in vitro. | 2010 | Arch. Pharm. Res. | pmid:20607492 |
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| Jeong DM et al. | Comparative antioxidant activity and HPLC profiles of some selected Korean thistles. | 2008 | Arch. Pharm. Res. | pmid:18277604 |
| Kim JW et al. | Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation. | 2012 | Arch. Pharm. Res. | pmid:22370792 |
| Yoon YA et al. | Relationships between the larval growth inhibition of Caenorhabditis elegans by apigenin derivatives and their structures. | 2006 | Arch. Pharm. Res. | pmid:16903079 |
| Park HS et al. | Antioxidant flavone glycosides from the leaves of Sasa borealis. | 2007 | Arch. Pharm. Res. | pmid:17366736 |