apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Neurodegenerative Diseases D019636 32 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Gastritis D005756 27 associated lipids
Glioblastoma D005909 27 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Cystitis D003556 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with apigenin

Download all related citations
Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Hu JJ et al. Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation. 2018 Microb. Pathog. pmid:29604422
Vrhovac Madunić I et al. Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells. 2018 Naunyn Schmiedebergs Arch. Pharmacol. pmid:29541820
Ren K et al. Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing Inflammation. 2018 Cell. Physiol. Biochem. pmid:29975943
Šarić Mustapić D et al. The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. 2018 Molecules pmid:30301254
Zhu Q et al. Comparison of flavonoids and isoflavonoids to inhibit rat and human 11β-hydroxysteroid dehydrogenase 1 and 2. 2018 Steroids pmid:29425740
Melguizo-Rodríguez L et al. Effect of olive oil phenolic compounds on osteoblast differentiation. 2018 Eur. J. Clin. Invest. pmid:29392706
Ni G et al. Synthesis of Scutellarein Derivatives with a Long Aliphatic Chain and Their Biological Evaluation against Human Cancer Cells. 2018 Molecules pmid:29389889
Rimal H et al. Hydroxylation of Resveratrol with DoxA In Vitro: An Enzyme with the Potential for the Bioconversion of a Bioactive Stilbene. 2018 J. Microbiol. Biotechnol. pmid:29385664
Renda G et al. Evaluation of in vivo analgesic activity of Scrophularia kotscyhana and isolation of bioactive compounds through activity-guided fractionation. 2018 Nat. Prod. Res. pmid:28758426
Zengin G et al. Multiple pharmacological approaches on Fibigia eriocarpa extracts by in vitro and computational assays. 2018 Fundam Clin Pharmacol pmid:29505673
Cheruvu HS et al. LC-MS/MS method for the simultaneous quantification of luteolin, wedelolactone and apigenin in mice plasma using hansen solubility parameters for liquid-liquid extraction: Application to pharmacokinetics of Eclipta alba chloroform fraction. 2018 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29518720
Vieira FN et al. Long-Term Effect on Bioactive Components and Antioxidant Activity of Thermal and High-Pressure Pasteurization of Orange Juice. 2018 Molecules pmid:30347848
Wang X et al. Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro. 2018 Ren Fail pmid:30278824
Han T et al. Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. 2018 Eur J Med Chem pmid:30243153
Kowalczyk A et al. Insights into novel anticancer applications for apigenin. 2017 Adv Clin Exp Med pmid:29211364
You L et al. Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. 2017 Bioorg. Med. Chem. Lett. pmid:29157862
He X et al. Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat. 2017 Am. J. Chin. Med. pmid:29121796
Wu W et al. Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique. 2017 Drug Deliv pmid:29115900
Tu F et al. Angiogenic effects of apigenin on endothelial cells after hypoxia-reoxygenation via the caveolin-1 pathway. 2017 Int. J. Mol. Med. pmid:29039442
Dang Y et al. Protective effects of apigenin against acrylonitrile-induced subchronic sperm injury in rats. 2017 Food Chem. Toxicol. pmid:28963002
Agah S et al. Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS-induced inflammation in colonic myofibroblasts. 2017 Mol Nutr Food Res pmid:28155259
Jin X et al. Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. 2017 Int J Nanomedicine pmid:28761344
Gu T et al. Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative. 2017 Molecules pmid:28635646
Nurdiana S et al. Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. 2017 BMC Complement Altern Med pmid:28576138
Bauer D et al. Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. 2017 PLoS ONE pmid:28441391
Meng S et al. Apigenin inhibits renal cell carcinoma cell proliferation. 2017 Oncotarget pmid:28423637
Zhong Y et al. Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. 2017 Toxicon pmid:28734981
Elhennawy MG and Lin HS Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. 2017 J Pharm Biomed Anal pmid:28494337
Alvin JW and Lacy DB Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. 2017 J. Struct. Biol. pmid:28433497
Hicks DF et al. Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. 2017 Sci Rep pmid:28256512
Min JW et al. Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. 2017 Oncotarget pmid:28424420
Yang LL et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. 2017 Biochim Biophys Acta Mol Basis Dis pmid:27903431
Perrott KM et al. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. 2017 Geroscience pmid:28378188
Stump TA et al. The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. 2017 J. Pharm. Pharmacol. pmid:28349530
Sun XP et al. Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. 2017 Arch. Pharm. Res. pmid:28315259
Ferrazzi P et al. Pollination effects on antioxidant content of Perilla frutescens seeds analysed by NMR spectroscopy. 2017 Nat. Prod. Res. pmid:28278651
Verma S et al. Natural polyphenolic inhibitors against the antiapoptotic BCL-2. 2017 J. Recept. Signal Transduct. Res. pmid:28264627
Kalivarathan J et al. Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet. 2017 Biomed. Pharmacother. pmid:28237914
Wang N et al. Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense. 2017 In Vitro Cell. Dev. Biol. Anim. pmid:28181104
Telange DR et al. Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential. 2017 Eur J Pharm Sci pmid:27939619
Zhang L et al. Comparative study of the binding of 3 flavonoids to the fat mass and obesity-associated protein by spectroscopy and molecular modeling. 2017 J. Mol. Recognit. pmid:28058739
Naik PM and Al-Khayri JM Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. 2017 Methods Mol. Biol. pmid:28755356
Grigalius I and Petrikaite V Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. 2017 Molecules pmid:29215574
Granato M et al. Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. 2017 J. Exp. Clin. Cancer Res. pmid:29179721
Fan H et al. Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. 2017 Med. Sci. Monit. pmid:29172017
Gu C et al. Preparation of Vitexin Nanoparticles by Combining the Antisolvent Precipitation and High Pressure Homogenization Approaches Followed by Lyophilization for Dissolution Rate Enhancement. 2017 Molecules pmid:29165376
Liao M et al. Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29127056
Jeong KM et al. Identification of Major Flavone C-Glycosides and Their Optimized Extraction from Cymbidium kanran Using Deep Eutectic Solvents. 2017 Molecules pmid:29156555
Wu T et al. Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). 2017 Pharmacol Rep pmid:29128807
Medhat AM et al. Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. 2017 Tumour Biol. pmid:29022496
Ganesan K and Xu B Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. 2017 Ann. N. Y. Acad. Sci. pmid:28891090
Hou L et al. Scutellarin Inhibits Proliferation, Invasion, and Tumorigenicity in Human Breast Cancer Cells by Regulating HIPPO-YAP Signaling Pathway. 2017 Med. Sci. Monit. pmid:29079722
Zhou RJ et al. Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. 2017 Biochem. Biophys. Res. Commun. pmid:28867192
Shan S et al. Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. 2017 J. Agric. Food Chem. pmid:28829588
Britto SM et al. Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. 2017 Mutat. Res. pmid:28735741
Wen L et al. An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. 2017 Molecules pmid:28486427
Jangdey MS et al. Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. 2017 Drug Deliv pmid:28687053
Perez-Leal O et al. Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. 2017 J. Biol. Chem. pmid:28684421
Hassoun SM et al. Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. 2017 Tumour Biol. pmid:28651490
Sang Y et al. Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. 2017 Food Funct pmid:28598487
Malik S et al. Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. 2017 Am. J. Physiol. Renal Physiol. pmid:28566504
Yao HM et al. [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. 2017 Zhonghua Xin Xue Guan Bing Za Zhi pmid:28545285
Fernandes LM et al. Genotoxicity and Antigenotoxicity Assessments of the Flavonoid Vitexin by the Drosophila melanogaster Somatic Mutation and Recombination Test. 2017 J Med Food pmid:28541831
Che Ahmad Tantowi NA et al. Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. 2017 Menopause pmid:28640163
Li J et al. Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. 2017 World J. Gastroenterol. pmid:28611514
Chen JL and Ko WC Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. 2017 Eur. J. Pharmacol. pmid:28603044
Karim R et al. Development and evaluation of injectable nanosized drug delivery systems for apigenin. 2017 Int J Pharm pmid:28456651
Soyman Z et al. Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. 2017 Balkan Med J pmid:28443590
Chen F et al. An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. 2017 Ultrason Sonochem pmid:28427633
Lin CM et al. Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. 2017 Sci Rep pmid:28337019
Pápay ZE et al. Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity. 2017 J Aerosol Med Pulm Drug Deliv pmid:28282259
Bolzon LB et al. Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems. 2017 J. Inorg. Biochem. pmid:28236787
Rašković A et al. Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model. 2017 Eur J Drug Metab Pharmacokinet pmid:28255865
Liu HJ et al. Apigenin alleviates STZ-induced diabetic cardiomyopathy. 2017 Mol. Cell. Biochem. pmid:28176247
Maher HM et al. Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS. 2017 J Pharm Biomed Anal pmid:28167419
Wei X et al. Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. 2017 Clin. Sci. pmid:28143892
Espargaró A et al. Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. 2017 J. Nat. Prod. pmid:28128562
Zhou Z et al. Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. 2017 Anticancer Drugs pmid:28125432
Erdogan S et al. The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. 2017 Biomed. Pharmacother. pmid:28107698
Thirusangu P et al. Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. 2017 Biochem. Biophys. Res. Commun. pmid:28104392
Yang N et al. Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. 2017 Mol Med Rep pmid:28035355
Banerjee K et al. Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions. 2017 J Colloid Interface Sci pmid:28012918
Ke Y et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. 2017 Biochem. Biophys. Res. Commun. pmid:27998773
Li Y et al. Pharmacokinetic Study of Swertisin by HPLC-MS/MS After Intravenous Administration in Rats. 2017 J Chromatogr Sci pmid:27993862
Wang B and Zhao XH Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells. 2017 Oncol. Rep. pmid:27959417
Hithamani G et al. Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells. 2017 J. Biosci. pmid:29229878
Tseng TH et al. Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. 2017 Environ. Toxicol. pmid:26872304
Sharma N et al. Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativus Targeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena. 2017 Med Chem pmid:27834134
Tang D et al. Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. 2017 Expert Opin Drug Metab Toxicol pmid:27766890
Lecomte S et al. Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. 2017 Toxicol. Appl. Pharmacol. pmid:28396216
Tan YQ et al. Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. 2017 Mol. Cell. Biochem. pmid:27778136
Oh HK et al. Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice. 2017 J. Psychopharmacol. (Oxford) pmid:27729563
Pápay ZE et al. Controlled Release Oral Delivery of Apigenin Containing Pellets with Antioxidant Activity. 2017 Curr Drug Deliv pmid:27264725
Gutiérrez-Venegas G and González-Rosas Z Apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells. 2017 Arch. Pharm. Res. pmid:27193174
Wong TY et al. Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. 2017 Biomed. Pharmacother. pmid:29198743
Wang J et al. Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. 2017 Int J Nanomedicine pmid:29158673
Hassan SM et al. Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. 2017 Pharm Biol pmid:28064632
Salazar-Aguilar S et al. Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. 2017 Nutrients pmid:28757593
Golea L et al. Phytochemical components and biological activities of Silene arenarioides Desf. 2017 Nat. Prod. Res. pmid:28278644
Gómez-Zorita S et al. Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes. 2017 J Transl Med pmid:29162103