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Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats. |
2018 |
Nanomedicine |
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Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway. |
2018 |
Drug Des Devel Ther |
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Dose- and time-dependent pharmacokinetics of apigenin trimethyl ether. |
2018 |
Eur J Pharm Sci |
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Vitexin inhibits Aβ induced toxicity in Neuro-2a cells by augmenting Nrf-2/HO-1 dependent antioxidant pathway and regulating lipid homeostasis by the activation of LXR-α. |
2018 |
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Development and characterization of a green procedure for apigenin extraction from Scutellaria barbata D. Don. |
2018 |
Food Chem |
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Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. |
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Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity. |
2018 |
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Food Chem. Toxicol. |
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Insights into novel anticancer applications for apigenin. |
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Adv Clin Exp Med |
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2017 |
Bioorg. Med. Chem. Lett. |
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Anthoxanthin Polyphenols Attenuate Aβ Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease. |
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CNS Neurosci Ther |
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Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. |
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J Complement Integr Med |
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Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. |
2017 |
Molecules |
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Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. |
2017 |
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Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. |
2017 |
Molecules |
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Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives. |
2017 |
Chin J Nat Med |
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Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization. |
2017 |
J. Proteome Res. |
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Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. |
2017 |
Oncotarget |
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Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. |
2017 |
Toxicon |
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Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. |
2017 |
J Pharm Biomed Anal |
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Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. |
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J. Struct. Biol. |
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Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. |
2017 |
Sci Rep |
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Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. |
2017 |
Oncotarget |
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Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. |
2017 |
Biochim Biophys Acta Mol Basis Dis |
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Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. |
2017 |
Geroscience |
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The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. |
2017 |
J. Pharm. Pharmacol. |
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Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. |
2017 |
Arch. Pharm. Res. |
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Pollination effects on antioxidant content of Perilla frutescens seeds analysed by NMR spectroscopy. |
2017 |
Nat. Prod. Res. |
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Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. |
2017 |
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Natural polyphenolic inhibitors against the antiapoptotic BCL-2. |
2017 |
J. Recept. Signal Transduct. Res. |
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Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. |
2017 |
Methods Mol. Biol. |
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Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. |
2017 |
Molecules |
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Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. |
2017 |
J. Exp. Clin. Cancer Res. |
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Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. |
2017 |
Med. Sci. Monit. |
pmid:29172017
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Preparation of Vitexin Nanoparticles by Combining the Antisolvent Precipitation and High Pressure Homogenization Approaches Followed by Lyophilization for Dissolution Rate Enhancement. |
2017 |
Molecules |
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Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. |
2017 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. |
2017 |
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Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. |
2017 |
Ann. N. Y. Acad. Sci. |
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Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. |
2017 |
Biochem. Biophys. Res. Commun. |
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Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. |
2017 |
J. Agric. Food Chem. |
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Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. |
2017 |
Mutat. Res. |
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An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. |
2017 |
Molecules |
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Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. |
2017 |
Drug Deliv |
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Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. |
2017 |
J. Biol. Chem. |
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Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. |
2017 |
Tumour Biol. |
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Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. |
2017 |
Int J Mol Sci |
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Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. |
2017 |
Mol Med Rep |
pmid:28849116
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Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. |
2017 |
Med. Sci. Monit. |
pmid:28821706
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Liu S and Ho PC |
Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. |
2017 |
J. Pharm. Pharmacol. |
pmid:28809432
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Fallatah O and Georges E |
Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. |
2017 |
Int. J. Antimicrob. Agents |
pmid:28807879
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Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. |
2017 |
Menopause |
pmid:28640163
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Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. |
2017 |
World J. Gastroenterol. |
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Chen JL and Ko WC |
Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. |
2017 |
Eur. J. Pharmacol. |
pmid:28603044
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miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. |
2017 |
Tumour Biol. |
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Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. |
2017 |
Biochim Biophys Acta Rev Cancer |
pmid:28359741
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Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. |
2017 |
Drug Dev Ind Pharm |
pmid:28358225
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Development and evaluation of injectable nanosized drug delivery systems for apigenin. |
2017 |
Int J Pharm |
pmid:28456651
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Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. |
2017 |
J Clin Neurosci |
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Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. |
2017 |
Balkan Med J |
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Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. |
2017 |
Brain Res. |
pmid:28336272
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An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. |
2017 |
Ultrason Sonochem |
pmid:28427633
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Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. |
2017 |
Planta Med. |
pmid:28288492
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Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation. |
2017 |
Mol. Immunol. |
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Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. |
2017 |
Oncol. Rep. |
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Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems. |
2017 |
J. Inorg. Biochem. |
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Apigenin alleviates STZ-induced diabetic cardiomyopathy. |
2017 |
Mol. Cell. Biochem. |
pmid:28176247
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Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS. |
2017 |
J Pharm Biomed Anal |
pmid:28167419
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Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. |
2017 |
Clin. Sci. |
pmid:28143892
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Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. |
2017 |
J. Nat. Prod. |
pmid:28128562
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Zhou Z et al. |
Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. |
2017 |
Anticancer Drugs |
pmid:28125432
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The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. |
2017 |
Biomed. Pharmacother. |
pmid:28107698
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Thirusangu P et al. |
Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. |
2017 |
Biochem. Biophys. Res. Commun. |
pmid:28104392
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Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. |
2017 |
Mol Med Rep |
pmid:28035355
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Wang F et al. |
Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. |
2017 |
Chem. Biol. Interact. |
pmid:28803762
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Gaballah HH et al. |
Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. |
2017 |
Toxicol. Appl. Pharmacol. |
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Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells. |
2017 |
J. Biosci. |
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Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. |
2017 |
Environ. Toxicol. |
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Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii. |
2017 |
Fitoterapia |
pmid:27889540
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Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. |
2017 |
Phytochemistry |
pmid:27889245
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Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. |
2017 |
Arch. Oral Biol. |
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Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. |
2017 |
J Chromatogr Sci |
pmid:27884870
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Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration. |
2017 |
Curr. Med. Chem. |
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Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. |
2017 |
J Asian Nat Prod Res |
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Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativus Targeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena. |
2017 |
Med Chem |
pmid:27834134
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Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. |
2017 |
Expert Opin Drug Metab Toxicol |
pmid:27766890
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Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. |
2017 |
Mol. Cell. Biochem. |
pmid:27778136
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Identification of a flavonoid C-glycoside as potent antioxidant. |
2017 |
Free Radic. Biol. Med. |
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Controlled Release Oral Delivery of Apigenin Containing Pellets with Antioxidant Activity. |
2017 |
Curr Drug Deliv |
pmid:27264725
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Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. |
2017 |
Biomed. Pharmacother. |
pmid:29198743
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Wang J et al. |
Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. |
2017 |
Int J Nanomedicine |
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Hassan SM et al. |
Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. |
2017 |
Pharm Biol |
pmid:28064632
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Salazar-Aguilar S et al. |
Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. |
2017 |
Nutrients |
pmid:28757593
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Phytochemical components and biological activities of Silene arenarioides Desf. |
2017 |
Nat. Prod. Res. |
pmid:28278644
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Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes. |
2017 |
J Transl Med |
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