apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Neurodegenerative Diseases D019636 32 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Gastritis D005756 27 associated lipids
Glioblastoma D005909 27 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Cystitis D003556 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Translocation, Genetic D014178 20 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Bhattacharya S et al. Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats. 2018 Nanomedicine pmid:29802937
Gu CB et al. Characterization, culture medium optimization and antioxidant activity of an endophytic vitexin-producing fungus Dichotomopilus funicola Y3 from pigeon pea [Cajanus cajan (L.) Millsp.]. 2018 J. Appl. Microbiol. pmid:29791772
Zhu J et al. Protective effects of Hand.- Mazz. (EBHM) extract in retinal neurodegeneration models. 2018 Mol. Vis. pmid:29769797
Amiri M et al. Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice. 2018 Phytother Res pmid:29748995
Wu TC et al. Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. 2018 Chem. Biol. Interact. pmid:30016632
Lim H et al. Flavonoids interfere with NLRP3 inflammasome activation. 2018 Toxicol. Appl. Pharmacol. pmid:29960001
Hu M et al. Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway. 2018 Drug Des Devel Ther pmid:29588573
Elhennawy MG and Lin HS Dose- and time-dependent pharmacokinetics of apigenin trimethyl ether. 2018 Eur J Pharm Sci pmid:29574080
Malar DS et al. Vitexin inhibits Aβ induced toxicity in Neuro-2a cells by augmenting Nrf-2/HO-1 dependent antioxidant pathway and regulating lipid homeostasis by the activation of LXR-α. 2018 Toxicol In Vitro pmid:29545167
Yang YC and Wei MC Development and characterization of a green procedure for apigenin extraction from Scutellaria barbata D. Don. 2018 Food Chem pmid:29478557
Jin UH et al. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. 2018 Toxicol. Sci. pmid:29584932
Li Y et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. 2018 Toxicol. Lett. pmid:29753067
van Vugt-Lussenburg BMA et al. Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity. 2018 Reprod. Toxicol. pmid:29162470
Kang CH et al. Apigenin promotes TRAIL-mediated apoptosis regardless of ROS generation. 2018 Food Chem. Toxicol. pmid:29247770
Kowalczyk A et al. Insights into novel anticancer applications for apigenin. 2017 Adv Clin Exp Med pmid:29211364
You L et al. Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. 2017 Bioorg. Med. Chem. Lett. pmid:29157862
Pate KM et al. Anthoxanthin Polyphenols Attenuate Aβ Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease. 2017 CNS Neurosci Ther pmid:27864869
Ghazanfar K et al. Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. 2017 J Complement Integr Med pmid:28731312
Sun Y et al. Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. 2017 Molecules pmid:28696360
Seo HS et al. Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. 2017 Oncol. Rep. pmid:28656316
Spilovska K et al. Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. 2017 Molecules pmid:28621747
Salmani JMM et al. Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives. 2017 Chin J Nat Med pmid:28558867
Elmasri WA et al. Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization. 2017 J. Proteome Res. pmid:28541047
Yang PM et al. Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. 2017 Oncotarget pmid:28526810
Zhong Y et al. Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. 2017 Toxicon pmid:28734981
Elhennawy MG and Lin HS Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. 2017 J Pharm Biomed Anal pmid:28494337
Alvin JW and Lacy DB Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. 2017 J. Struct. Biol. pmid:28433497
Hicks DF et al. Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. 2017 Sci Rep pmid:28256512
Min JW et al. Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. 2017 Oncotarget pmid:28424420
Yang LL et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. 2017 Biochim Biophys Acta Mol Basis Dis pmid:27903431
Perrott KM et al. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. 2017 Geroscience pmid:28378188
Stump TA et al. The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. 2017 J. Pharm. Pharmacol. pmid:28349530
Sun XP et al. Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. 2017 Arch. Pharm. Res. pmid:28315259
Ferrazzi P et al. Pollination effects on antioxidant content of Perilla frutescens seeds analysed by NMR spectroscopy. 2017 Nat. Prod. Res. pmid:28278651
Anusha C et al. Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. 2017 Chem. Biol. Interact. pmid:28389404
Verma S et al. Natural polyphenolic inhibitors against the antiapoptotic BCL-2. 2017 J. Recept. Signal Transduct. Res. pmid:28264627
Naik PM and Al-Khayri JM Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. 2017 Methods Mol. Biol. pmid:28755356
Grigalius I and Petrikaite V Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. 2017 Molecules pmid:29215574
Granato M et al. Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. 2017 J. Exp. Clin. Cancer Res. pmid:29179721
Fan H et al. Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. 2017 Med. Sci. Monit. pmid:29172017
Gu C et al. Preparation of Vitexin Nanoparticles by Combining the Antisolvent Precipitation and High Pressure Homogenization Approaches Followed by Lyophilization for Dissolution Rate Enhancement. 2017 Molecules pmid:29165376
Liao M et al. Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29127056
Medhat AM et al. Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. 2017 Tumour Biol. pmid:29022496
Ganesan K and Xu B Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. 2017 Ann. N. Y. Acad. Sci. pmid:28891090
Zhou RJ et al. Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. 2017 Biochem. Biophys. Res. Commun. pmid:28867192
Shan S et al. Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. 2017 J. Agric. Food Chem. pmid:28829588
Britto SM et al. Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. 2017 Mutat. Res. pmid:28735741
Wen L et al. An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. 2017 Molecules pmid:28486427
Jangdey MS et al. Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. 2017 Drug Deliv pmid:28687053
Perez-Leal O et al. Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. 2017 J. Biol. Chem. pmid:28684421
Hassoun SM et al. Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. 2017 Tumour Biol. pmid:28651490
Tamayose CI et al. Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. 2017 Int J Mol Sci pmid:28906474
Zhang L et al. Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. 2017 Mol Med Rep pmid:28849116
Tu F et al. Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. 2017 Med. Sci. Monit. pmid:28821706
Liu S and Ho PC Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. 2017 J. Pharm. Pharmacol. pmid:28809432
Fallatah O and Georges E Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. 2017 Int. J. Antimicrob. Agents pmid:28807879
Che Ahmad Tantowi NA et al. Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. 2017 Menopause pmid:28640163
Li J et al. Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. 2017 World J. Gastroenterol. pmid:28611514
Chen JL and Ko WC Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. 2017 Eur. J. Pharmacol. pmid:28603044
Wan Y et al. miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. 2017 Tumour Biol. pmid:28381178
Singhal SS et al. Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. 2017 Biochim Biophys Acta Rev Cancer pmid:28359741
Zhang Z et al. Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. 2017 Drug Dev Ind Pharm pmid:28358225
Karim R et al. Development and evaluation of injectable nanosized drug delivery systems for apigenin. 2017 Int J Pharm pmid:28456651
Han Y et al. Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. 2017 J Clin Neurosci pmid:28342702
Soyman Z et al. Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. 2017 Balkan Med J pmid:28443590
Bian M et al. Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. 2017 Brain Res. pmid:28336272
Chen F et al. An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. 2017 Ultrason Sonochem pmid:28427633
Crascì L et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. 2017 Planta Med. pmid:28288492
Zhang S et al. Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation. 2017 Mol. Immunol. pmid:28288411
Zhao G et al. Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. 2017 Oncol. Rep. pmid:28260058
Bolzon LB et al. Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems. 2017 J. Inorg. Biochem. pmid:28236787
Liu HJ et al. Apigenin alleviates STZ-induced diabetic cardiomyopathy. 2017 Mol. Cell. Biochem. pmid:28176247
Maher HM et al. Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS. 2017 J Pharm Biomed Anal pmid:28167419
Wei X et al. Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. 2017 Clin. Sci. pmid:28143892
Espargaró A et al. Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. 2017 J. Nat. Prod. pmid:28128562
Zhou Z et al. Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. 2017 Anticancer Drugs pmid:28125432
Erdogan S et al. The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. 2017 Biomed. Pharmacother. pmid:28107698
Thirusangu P et al. Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. 2017 Biochem. Biophys. Res. Commun. pmid:28104392
Yang N et al. Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. 2017 Mol Med Rep pmid:28035355
Wang F et al. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. 2017 Chem. Biol. Interact. pmid:28803762
Gaballah HH et al. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. 2017 Toxicol. Appl. Pharmacol. pmid:28025107
Hithamani G et al. Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells. 2017 J. Biosci. pmid:29229878
Tseng TH et al. Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. 2017 Environ. Toxicol. pmid:26872304
Zou Z et al. Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii. 2017 Fitoterapia pmid:27889540
Zou Z et al. Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. 2017 Phytochemistry pmid:27889245
Ketkaew Y et al. Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. 2017 Arch. Oral Biol. pmid:27886571
Liu H et al. Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. 2017 J Chromatogr Sci pmid:27884870
Wu CY et al. Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration. 2017 Curr. Med. Chem. pmid:27855618
Guo TT et al. Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. 2017 J Asian Nat Prod Res pmid:27848262
Sharma N et al. Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativus Targeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena. 2017 Med Chem pmid:27834134
Tang D et al. Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. 2017 Expert Opin Drug Metab Toxicol pmid:27766890
Tan YQ et al. Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. 2017 Mol. Cell. Biochem. pmid:27778136
Wen L et al. Identification of a flavonoid C-glycoside as potent antioxidant. 2017 Free Radic. Biol. Med. pmid:28587909
Pápay ZE et al. Controlled Release Oral Delivery of Apigenin Containing Pellets with Antioxidant Activity. 2017 Curr Drug Deliv pmid:27264725
Wong TY et al. Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. 2017 Biomed. Pharmacother. pmid:29198743
Wang J et al. Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. 2017 Int J Nanomedicine pmid:29158673
Hassan SM et al. Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. 2017 Pharm Biol pmid:28064632
Salazar-Aguilar S et al. Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. 2017 Nutrients pmid:28757593
Golea L et al. Phytochemical components and biological activities of Silene arenarioides Desf. 2017 Nat. Prod. Res. pmid:28278644
Gómez-Zorita S et al. Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes. 2017 J Transl Med pmid:29162103