| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sang SM et al. | [Studies on the flavonol glycosides from the seeds of Vaccaria segetalis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512436 |
| Zhang WD et al. | [Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516462 |
| Zhang J et al. | [Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516463 |
| Nakazawa T and Ohsawa K | Metabolites of orally administered Perilla frutescens extract in rats and humans. | 2000 | Biol. Pharm. Bull. | pmid:10706426 |
| Hiremath SP et al. | Antifertility and hormonal properties of flavones of Striga orobanchioides. | 2000 | Eur. J. Pharmacol. | pmid:10720651 |
| Romanová D et al. | Determination of apigenin in rat plasma by high-performance liquid chromatography. | 2000 | J Chromatogr A | pmid:10722103 |
| Pieroni A and Pachaly P | Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L. | 2000 | Pharmazie | pmid:10683879 |
| Breinholt V et al. | Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. | 2000 | Food Chem. Toxicol. | pmid:10942316 |
| Ashida H | Suppressive effects of flavonoids on dioxin toxicity. | 2000 | Biofactors | pmid:11216487 |
| Chan EC et al. | Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10672869 |
| De Santi C et al. | Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. | 2000 | Xenobiotica | pmid:11055264 |
| Segaert S et al. | The flavonoid apigenin suppresses vitamin D receptor expression and vitamin D responsiveness in normal human keratinocytes. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652242 |
| Griffith AP and Collison MW | Improved methods for the extraction and analysis of isoflavones from soy-containing foods and nutritional supplements by reversed-phase high-performance liquid chromatography and liquid chromatography-mass spectrometry. | 2001 | J Chromatogr A | pmid:11355838 |
| Liu JQ et al. | [Studies on the chemical constituents from Chrysanthemum morifolium Ramat]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776368 |
| Brahmbhatt SR et al. | Study of biochemical prevalence indicators for the assessment of iodine deficiency disorders in adults at field conditions in Gujarat (India). | 2001 | Asia Pac J Clin Nutr | pmid:11708609 |
| Makino T et al. | Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. | 2001 | Biol. Pharm. Bull. | pmid:11642335 |
| Tammi R et al. | Hyaluronan enters keratinocytes by a novel endocytic route for catabolism. | 2001 | J. Biol. Chem. | pmid:11451952 |
| Hanyaloglu AC et al. | Casein kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimeric gonadotropin-releasing hormone receptors contribute to beta-arrestin-dependent internalization. | 2001 | J. Biol. Chem. | pmid:11278484 |
| Ren YL and Yang JS | [Study on chemical constituents of Hemistepta lyrata Bunge]. | 2001 | Yao Xue Xue Bao | pmid:12579973 |
| Leslie EM et al. | Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. | 2001 | Mol. Pharmacol. | pmid:11306701 |
| Galati G et al. | Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation. | 2001 | Free Radic. Biol. Med. | pmid:11182292 |
| Kong LD et al. | Glycosides and xanthine oxidase inhibitors from Conyza bonariensis. | 2001 | Phytochemistry | pmid:11576616 |
| Stull ND et al. | Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins. | 2001 | Brain Res. Dev. Brain Res. | pmid:11557097 |
| Abou-Zaid MM et al. | Acylated flavone C-glycosides from Cucumis sativus. | 2001 | Phytochemistry | pmid:11524127 |
| Haribal M and Renwick JA | Seasonal and population variation in flavonoid and alliarinoside content of Alliaria petiolata. | 2001 | J. Chem. Ecol. | pmid:11521398 |
| Wang CN et al. | The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. | 2001 | J. Biol. Chem. | pmid:11083861 |
| Saarinen N et al. | No evidence for the in vivo activity of aromatase-inhibiting flavonoids. | 2001 | J. Steroid Biochem. Mol. Biol. | pmid:11595503 |
| Oberdörster E et al. | Common phytochemicals are ecdysteroid agonists and antagonists: a possible evolutionary link between vertebrate and invertebrate steroid hormones. | 2001 | J. Steroid Biochem. Mol. Biol. | pmid:11457661 |
| Lans C et al. | Medicinal and ethnoveterinary remedies of hunters in Trinidad. | 2001 | BMC Complement Altern Med | pmid:11737880 |
| Galietta LV et al. | Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11600438 |
| Chen SB et al. | Aquiledine and isoaquiledine, novel flavonoid alkaloids from Aquilegia ecalcarata. | 2001 | J. Nat. Prod. | pmid:11170673 |
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| Shen J et al. | Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. | 2001 | J. Immunol. | pmid:11673497 |
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| Stochmal A et al. | Acylated apigenin glycosides from alfalfa (Medicago sativa L.) var. Artal. | 2001 | Phytochemistry | pmid:11454348 |
| Gobbi M et al. | In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. | 2001 | Pharmacopsychiatry | pmid:11518075 |
| Aquino R et al. | Phenolic constituents and antioxidant activity of an extract of Anthuriumversicolor leaves. | 2001 | J. Nat. Prod. | pmid:11520218 |
| Kyriakopoulou I et al. | Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia. | 2001 | J. Nat. Prod. | pmid:11520237 |
| Martens S et al. | Cloning of parsley flavone synthase I. | 2001 | Phytochemistry | pmid:11524111 |
| Landesman-Bollag E et al. | Protein kinase CK2: signaling and tumorigenesis in the mammary gland. | 2001 | Mol. Cell. Biochem. | pmid:11827167 |
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| Allen SW et al. | The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. | 2001 | Drug Metab. Dispos. | pmid:11454723 |
| Kitada C et al. | Differential expression of two cytochrome P450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of Perilla frutescens. | 2001 | Plant Cell Physiol. | pmid:11773526 |
| Huang X et al. | 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. | 2001 | J. Med. Chem. | pmid:11384234 |
| Fischer H et al. | Partial restoration of defective chloride conductance in DeltaF508 CF mice by trimethylamine oxide. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11404245 |
| Nejaty H et al. | Differing effects of endocrine-disrupting chemicals on basal and FSH-stimulated progesterone production in rat granulosa-luteal cells. | 2001 | Exp. Biol. Med. (Maywood) | pmid:11395928 |
| Liang YC et al. | Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. | 2001 | FEBS Lett. | pmid:11343698 |
| Begum AA et al. | Specific flavonoids induced nod gene expression and pre-activated nod genes of Rhizobium leguminosarum increased pea (Pisum sativum L.) and lentil (Lens culinaris L.) nodulation in controlled growth chamber environments. | 2001 | J. Exp. Bot. | pmid:11457914 |
| Qu J et al. | Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry. | 2001 | J Chromatogr A | pmid:11587333 |