| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Griffith AP and Collison MW | Improved methods for the extraction and analysis of isoflavones from soy-containing foods and nutritional supplements by reversed-phase high-performance liquid chromatography and liquid chromatography-mass spectrometry. | 2001 | J Chromatogr A | pmid:11355838 |
| Brahmbhatt SR et al. | Study of biochemical prevalence indicators for the assessment of iodine deficiency disorders in adults at field conditions in Gujarat (India). | 2001 | Asia Pac J Clin Nutr | pmid:11708609 |
| Makino T et al. | Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. | 2001 | Biol. Pharm. Bull. | pmid:11642335 |
| Galati G et al. | Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation. | 2001 | Free Radic. Biol. Med. | pmid:11182292 |
| Lans C et al. | Medicinal and ethnoveterinary remedies of hunters in Trinidad. | 2001 | BMC Complement Altern Med | pmid:11737880 |
| Stochmal A et al. | Alfalfa (Medicago sativa L.) flavonoids. 1. Apigenin and luteolin glycosides from aerial parts. | 2001 | J. Agric. Food Chem. | pmid:11262024 |
| Vrinda B and Uma Devi P | Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin. | 2001 | Mutat. Res. | pmid:11673069 |
| Shen J et al. | Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. | 2001 | J. Immunol. | pmid:11673497 |
| Ricupero DA et al. | Apigenin decreases expression of the myofibroblast phenotype. | 2001 | FEBS Lett. | pmid:11591363 |
| Gupta S et al. | Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573952 |
| Witte MC et al. | Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry. | 2001 | Eur. J. Neurosci. | pmid:11576187 |
| Boveris AD et al. | Antioxidant capacity of a 3-deoxyanthocyanidin from soybean. | 2001 | Phytochemistry | pmid:11730874 |
| Qu J et al. | Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry. | 2001 | J Chromatogr A | pmid:11587333 |
| Yin F et al. | Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. | 2001 Jan-Feb | Anticancer Res. | pmid:11299771 |
| Bylka W | Isovitexin o-glucosides from Aquilegia vulgaris L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693732 |
| Matławska I | Flavonoid compounds in the flowers of Kitaibelia vitifolia Willd. (Malvaceae). | 2001 Mar-Apr | Acta Pol Pharm | pmid:11501790 |
| Kim HR et al. | Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A2. | 2001 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11993721 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Cohen MF et al. | Synergistic effect of deoxyanthocyanins from symbiotic fern Azolla spp. on hrmA gene induction in the cyanobacterium Nostoc punctiforme. | 2002 | Mol. Plant Microbe Interact. | pmid:12236594 |
| Engelmann C et al. | Apigenin--strong cytostatic and anti-angiogenic action in vitro contrasted by lack of efficacy in vivo. | 2002 | Phytomedicine | pmid:12403156 |
| Droillard M et al. | Different protein kinase families are activated by osmotic stresses in Arabidopsis thaliana cell suspensions. Involvement of the MAP kinases AtMPK3 and AtMPK6. | 2002 | FEBS Lett. | pmid:12220631 |
| Modolo LV et al. | Nitric oxide synthase-mediated phytoalexin accumulation in soybean cotyledons in response to the Diaporthe phaseolorum f. sp. meridionalis elicitor. | 2002 | Plant Physiol. | pmid:12427995 |
| Li J and Chen YT | [Two flavonoids from Lagopsis supina]. | 2002 | Yao Xue Xue Bao | pmid:12579758 |
| Gradolatto A et al. | Could apigenin metabolism explain the estrogenic effect of this flavonoid in the female immature rat? | 2002 | IARC Sci. Publ. | pmid:12484224 |
| Olszanecki R et al. | Flavonoids and nitric oxide synthase. | 2002 | J. Physiol. Pharmacol. | pmid:12512693 |
| Xu YQ et al. | [Recognition of three classes of skullcaps by FTIR spectroscopy combined with artificial neural networks]. | 2002 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12914171 |
| Agati G et al. | Flavonoid distribution in tissues of Phillyrea latifolia L. leaves as estimated by microspectrofluorometry and multispectral fluorescence microimaging. | 2002 | Photochem. Photobiol. | pmid:12403458 |
| Miro FA et al. | Persistent nuclear accumulation of protein kinase CK2 during the G1-phase of the cell cycle does not depend on the ERK1/2 pathway but requires active protein synthesis. | 2002 | Arch. Biochem. Biophys. | pmid:12361704 |
| Zétola M et al. | CNS activities of liquid and spray-dried extracts from Lippia alba-Verbenaceae (Brazilian false melissa). | 2002 | J Ethnopharmacol | pmid:12241997 |
| Exarchou V et al. | Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory. | 2002 | J. Agric. Food Chem. | pmid:12207464 |
| Snyder RD and Gillies PJ | Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells. | 2002 | Environ. Mol. Mutagen. | pmid:12489117 |
| Hien TV et al. | Radioprotective effects of vitexina for breast cancer patients undergoing radiotherapy with cobalt-60. | 2002 | Integr Cancer Ther | pmid:14664747 |
| Lu J et al. | Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils. | 2002 | Clin. Chim. Acta | pmid:11750278 |
| Lee WR et al. | Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. | 2002 | Biochem. Pharmacol. | pmid:11841797 |
| Cao Y et al. | Analysis of flavonoids in Ginkgo biloba L. and its phytopharmaceuticals by capillary electrophoresis with electrochemical detection. | 2002 | Anal Bioanal Chem | pmid:12324852 |
| Tsuchiya H et al. | Membrane-rigidifying effects of anti-cancer dietary factors. | 2002 | Biofactors | pmid:14530593 |
| Couladis M et al. | Antioxidant activity of polyphenols from Hypericum triquetrifolium Turra. | 2002 | Phytother Res | pmid:12458485 |
| Myhrstad MC et al. | Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. | 2002 | Free Radic. Biol. Med. | pmid:11864778 |
| Fiorani M et al. | Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes. | 2002 | Free Radic. Biol. Med. | pmid:11755318 |
| Sampson L et al. | Flavonol and flavone intakes in US health professionals. | 2002 | J Am Diet Assoc | pmid:12396158 |
| Lautraite S et al. | Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. | 2002 | Mutagenesis | pmid:11752233 |
| Frangne N et al. | Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. | 2002 | Plant Physiol. | pmid:11842175 |
| Afaq F et al. | Botanical antioxidants for chemoprevention of photocarcinogenesis. | 2002 | Front. Biosci. | pmid:11897547 |
| Kobayashi T et al. | Effect of flavonoids on cell cycle progression in prostate cancer cells. | 2002 | Cancer Lett. | pmid:11790449 |
| Llorens F et al. | Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation. | 2002 | FEBS Lett. | pmid:11801244 |
| McVean M et al. | A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin. | 2002 | Mol. Carcinog. | pmid:11807956 |
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| Aboutabl EA et al. | Phytochemical and pharmacological studies on Sideritis taurica Stephan ex Wild. | 2002 | J Ethnopharmacol | pmid:12241993 |
| Zhu CC et al. | Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. | 2002 | J. Biol. Chem. | pmid:12023974 |
| Usia T et al. | Constituents of Chinese propolis and their antiproliferative activities. | 2002 | J. Nat. Prod. | pmid:12027739 |