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Antithrombotic and antiplatelet activities of vicenin-2. |
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Blood Coagul. Fibrinolysis |
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The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid sources of Agrimoniae herba--The pharmacopoeial plant material. |
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Ameliorative Effect of Vicenin-2 and Scolymoside on TGFBIp-Induced Septic Responses. |
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Anti-hyperalgesic and Anti-inflammatory Activity of Alternanthera Maritima Extract and 2″-O-α-L-rhamnopyranosylvitexin in Mice. |
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In vitro-assessment of putative antiprogestin activities of phytochemicals and synthetic UV absorbers in human endometrial Ishikawa cells. |
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Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions. |
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J Sep Sci |
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Effects of germination on the nutritional properties, phenolic profiles, and antioxidant activities of buckwheat. |
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Vitexin protects brain against ischemia/reperfusion injury via modulating mitogen-activated protein kinase and apoptosis signaling in mice. |
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Phytomedicine |
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Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. |
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Eur J Med Chem |
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Effect of Apigenin on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction. |
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Clinical tolerability and pharmacokinetics of Erigerontis hydroxybenzene injection: results of a randomized phase I study in healthy Chinese volunteers. |
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Phytomedicine |
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Apigenin and Breast Cancers: From Chemistry to Medicine. |
2015 |
Anticancer Agents Med Chem |
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Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. |
2015 |
J Ethnopharmacol |
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Apigenin inhibits PMA-induced expression of pro-inflammatory cytokines and AP-1 factors in A549 cells. |
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Mol. Cell. Biochem. |
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Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis. |
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Biomed. Pharmacother. |
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Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium. |
2015 |
Br. J. Nutr. |
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Barlas N and Karabulut G |
Haematological and histopathological effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar female albino rats. |
2015 |
Hum Exp Toxicol |
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Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking. |
2015 |
J. Nutr. Biochem. |
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Flavonoid nanocrystals produced by ARTcrystal®-technology. |
2015 |
Int J Pharm |
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Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats. |
2015 |
Phytother Res |
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Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells. |
2015 |
Eur J Nutr |
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Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3‑derived sphere-forming cells. |
2015 |
Mol Med Rep |
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Protective effect of apigenin on ischemia/reperfusion injury of the isolated rat heart. |
2015 |
Cardiovasc. Toxicol. |
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Infusions of artichoke and milk thistle represent a good source of phenolic acids and flavonoids. |
2015 |
Food Funct |
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5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma. |
2015 |
Clin. Exp. Pharmacol. Physiol. |
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Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer. |
2015 |
Mol Med Rep |
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Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2α. |
2015 |
Mol Med Rep |
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Apigenin as an anti-quinolone-resistance antibiotic. |
2015 |
Int. J. Antimicrob. Agents |
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Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. |
2015 |
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Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus. |
2015 |
Appl. Environ. Microbiol. |
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Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα. |
2015 |
PLoS ONE |
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Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity. |
2015 |
PLoS ONE |
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Apigenin blocks IKKα activation and suppresses prostate cancer progression. |
2015 |
Oncotarget |
pmid:26435478
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Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin. |
2015 |
Oncotarget |
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Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice. |
2015 |
PLoS ONE |
pmid:26379052
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Chemical Constituents and Antibacterial Properties of Indocalamus latifolius McClure Leaves, the Packaging Material for "Zongzi". |
2015 |
Molecules |
pmid:26343625
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Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1. |
2015 |
Mol Med Rep |
pmid:26300442
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The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions. |
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Plant Physiol. |
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Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. |
2015 |
Biomed. Chromatogr. |
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Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. |
2015 |
Biol. Pharm. Bull. |
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Apigenin inhibits pancreatic stellate cell activity in pancreatitis. |
2015 |
J. Surg. Res. |
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Characterization of the intestinal absorption of seven flavonoids from the flowers of Trollius chinensis using the Caco-2 cell monolayer model. |
2015 |
PLoS ONE |
pmid:25789809
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Antiviral activity of Paulownia tomentosa against enterovirus 71 of hand, foot, and mouth disease. |
2015 |
Biol. Pharm. Bull. |
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Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia. |
2015 |
J Neuroinflammation |
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Apigenin-7-glycoside prevents LPS-induced acute lung injury via downregulation of oxidative enzyme expression and protein activation through inhibition of MAPK phosphorylation. |
2015 |
Int J Mol Sci |
pmid:25590301
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effects of natural flavonoids on photosynthetic activity and cell integrity in Microcystis aeruginosa. |
2015 |
Toxins (Basel) |
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Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genotoxic potency. |
2015 |
Toxicol Ind Health |
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GRID and docking analyses reveal a molecular basis for flavonoid inhibition of Src family kinase activity. |
2015 |
J. Nutr. Biochem. |
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Protective effect of apigenin on Freund's complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway. |
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Chem. Biol. Interact. |
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Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. |
2015 |
Chem. Biol. Interact. |
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In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. |
2015 |
J. Biochem. Mol. Toxicol. |
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Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. |
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Chem. Biol. Interact. |
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Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. |
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Toxicol. Lett. |
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Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling. |
2015 |
J. Agric. Food Chem. |
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Separation of vitexin-4″-O-glucoside and vitexin-2″-O-rhamnoside from hawthorn leaves extracts using macroporous resins. |
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J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment. |
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J. Nat. Prod. |
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Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. |
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Eur J Med Chem |
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Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo. |
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Inflamm. Res. |
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Potential role of vitexin in alleviating heat stress-induced cytotoxicity: Regulatory effect of Hsp90 on ER stress-mediated autophagy. |
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Life Sci. |
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Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5. |
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Bioorg. Med. Chem. Lett. |
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Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-κB pathways in human lung epithelial cells. |
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Eur. J. Pharmacol. |
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Synthesis of scutellarein derivatives to increase biological activity and water solubility. |
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Bioorg. Med. Chem. |
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Stable knock-down of efflux transporters leads to reduced glucuronidation in UGT1A1-overexpressing HeLa cells: the evidence for glucuronidation-transport interplay. |
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Mol. Pharm. |
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Inhibitory Effect of Apigenin on Pharmacokinetics of Venlafaxine in vivo and in vitro. |
2015 |
Pharmacology |
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Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. |
2015 |
Neuropharmacology |
pmid:26187393
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Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. |
2015 |
Toxicol. Sci. |
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Comparison of inhibition capability of scutellarein and scutellarin towards important liver UDP-glucuronosyltransferase (UGT) isoforms. |
2014 |
Phytother Res |
pmid:23620377
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Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. |
2014 |
Sci Rep |
pmid:25257666
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The estrogenic effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar albino rats. |
2014 |
Toxicol. Lett. |
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Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. |
2014 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:25289789
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Preparation of two flavonoid glycosides with unique structures from barley seedlings by membrane separation technology and preparative high-performance liquid chromatography. |
2014 |
J Sep Sci |
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Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles. |
2014 |
Int J Pharm |
pmid:25269007
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Investigating sub-2 μm particle stationary phase supercritical fluid chromatography coupled to mass spectrometry for chemical profiling of chamomile extracts. |
2014 |
Anal. Chim. Acta |
pmid:25261902
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Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC-MS combined with enzyme channel blocking. |
2014 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Antiinflammatory effects and chemical constituents of Veronicastrum axillare. |
2014 |
Phytother Res |
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The apoptotic effect of apigenin on human gastric carcinoma cells through mitochondrial signal pathway. |
2014 |
Tumour Biol. |
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Protective effect of apigenin against N-nitrosodiethylamine (NDEA)-induced hepatotoxicity in albino rats. |
2014 |
Mutat Res Genet Toxicol Environ Mutagen |
pmid:24755254
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Rhizobium tibeticum activated with a mixture of flavonoids alleviates nickel toxicity in symbiosis with fenugreek (Trigonella foenum graecum L.). |
2014 |
Ecotoxicology |
pmid:24740320
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Islam MN et al. |
Vicenin 2 isolated from Artemisia capillaris exhibited potent anti-glycation properties. |
2014 |
Food Chem. Toxicol. |
pmid:24713265
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Treatment of dermatophytosis by a new antifungal agent 'apigenin'. |
2014 |
Mycoses |
pmid:24708558
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Simultaneous separation of apigenin, luteolin and rosmarinic acid from the aerial parts of the copper-tolerant plant Elsholtzia splendens. |
2014 |
Environ Sci Pollut Res Int |
pmid:24671394
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Wang H et al. |
Microwave-assisted simultaneous extraction of luteolin and apigenin from tree peony pod and evaluation of its antioxidant activity. |
2014 |
ScientificWorldJournal |
pmid:25405227
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Paramaguru R et al. |
Antidiabetic activity of Pterospermum acerifolium flowers and glucose uptake potential of bioactive fraction in L6 muscle cell lines with its HPLC fingerprint. |
2014 |
Biomed Res Int |
pmid:25401101
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Zhang M et al. |
Comparison of flavonoid compounds in the flavedo and juice of two pummelo cultivars (Citrus grandis L. Osbeck) from different cultivation regions in China. |
2014 |
Molecules |
pmid:25353383
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Expression level of a flavonoid 3'-hydroxylase gene determines pathogen-induced color variation in sorghum. |
2014 |
BMC Res Notes |
pmid:25346182
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Zhang W et al. |
Apigenin inhibits enterovirus-71 infection by disrupting viral RNA association with trans-acting factors. |
2014 |
PLoS ONE |
pmid:25330384
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Zhou H et al. |
Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats. |
2014 |
Molecules |
pmid:25268717
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Zhang X et al. |
Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages. |
2014 |
PLoS ONE |
pmid:25192391
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Liu LH et al. |
Induction of apoptosis by VB1 in breast cancer cells: the role of reactive oxygen species and Bcl-2 family proteins. |
2014 |
Int. J. Mol. Med. |
pmid:24276280
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Shukla S et al. |
Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway. |
2014 |
Carcinogenesis |
pmid:24067903
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Lakshmanan A et al. |
Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells. |
2014 |
Thyroid |
pmid:24400871
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Kuo CH et al. |
Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils. |
2014 |
J Ethnopharmacol |
pmid:24374236
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Purified vitexin compound 1 inhibits growth and angiogenesis through activation of FOXO3a by inactivation of Akt in hepatocellular carcinoma. |
2014 |
Int. J. Mol. Med. |
pmid:24337611
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Synthesis, nitric oxide release, and α-glucosidase inhibition of nitric oxide donating apigenin and chrysin derivatives. |
2014 |
Bioorg. Med. Chem. |
pmid:24508143
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Yu XX et al. |
Isolation and purification of orientin and vitexin from Trollius chinensis Bunge by high-speed counter-current chromatography. |
2014 |
Nat. Prod. Res. |
pmid:24650293
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Tang H et al. |
Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats. |
2014 |
Pharmacol. Biochem. Behav. |
pmid:24423938
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Neuroprotective effect of apigenin in rats after contusive spinal cord injury. |
2014 |
Neurol. Sci. |
pmid:24166720
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Ozkan G and Ozcan MM |
Some phenolic compounds of extracts obtained from Origanum species growing in Turkey. |
2014 |
Environ Monit Assess |
pmid:24691738
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Jin H et al. |
Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II. |
2014 |
Fitoterapia |
pmid:24468190
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