apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Neurodegenerative Diseases D019636 32 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Gastritis D005756 27 associated lipids
Glioblastoma D005909 27 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Cystitis D003556 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Lee W and Bae JS Antithrombotic and antiplatelet activities of vicenin-2. 2015 Blood Coagul. Fibrinolysis pmid:26126169
Andueza A et al. Oxidation pathways underlying the pro-oxidant effects of apigenin. 2015 Free Radic. Biol. Med. pmid:26119779
Granica S et al. The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid sources of Agrimoniae herba--The pharmacopoeial plant material. 2015 J Pharm Biomed Anal pmid:26092224
Lee W et al. Ameliorative Effect of Vicenin-2 and Scolymoside on TGFBIp-Induced Septic Responses. 2015 Inflammation pmid:26084452
de Santana Aquino DF et al. Anti-hyperalgesic and Anti-inflammatory Activity of Alternanthera Maritima Extract and 2″-O-α-L-rhamnopyranosylvitexin in Mice. 2015 Inflammation pmid:26045342
Yin Q et al. In vitro-assessment of putative antiprogestin activities of phytochemicals and synthetic UV absorbers in human endometrial Ishikawa cells. 2015 Gynecol. Endocrinol. pmid:26036805
Wei L et al. Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions. 2015 J Sep Sci pmid:25866087
Zhang G et al. Effects of germination on the nutritional properties, phenolic profiles, and antioxidant activities of buckwheat. 2015 J. Food Sci. pmid:25858540
Wang Y et al. Vitexin protects brain against ischemia/reperfusion injury via modulating mitogen-activated protein kinase and apoptosis signaling in mice. 2015 Phytomedicine pmid:25837275
Sang Z et al. Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. 2015 Eur J Med Chem pmid:25778991
Fonseca-Silva F et al. Effect of Apigenin on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction. 2015 J. Nat. Prod. pmid:25768915
Ju WZ et al. Clinical tolerability and pharmacokinetics of Erigerontis hydroxybenzene injection: results of a randomized phase I study in healthy Chinese volunteers. 2015 Phytomedicine pmid:25765839
Nabavi SM et al. Apigenin and Breast Cancers: From Chemistry to Medicine. 2015 Anticancer Agents Med Chem pmid:25738871
Niu C et al. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. 2015 J Ethnopharmacol pmid:25701748
Patil RH et al. Apigenin inhibits PMA-induced expression of pro-inflammatory cytokines and AP-1 factors in A549 cells. 2015 Mol. Cell. Biochem. pmid:25666088
Mustapha N et al. Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis. 2015 Biomed. Pharmacother. pmid:25661350
Mascaraque C et al. Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium. 2015 Br. J. Nutr. pmid:25654996
Barlas N and Karabulut G Haematological and histopathological effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar female albino rats. 2015 Hum Exp Toxicol pmid:25378093
Saeed M et al. Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking. 2015 J. Nutr. Biochem. pmid:25459885
Scholz P and Keck CM Flavonoid nanocrystals produced by ARTcrystal®-technology. 2015 Int J Pharm pmid:25448550
Wang XS et al. Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats. 2015 Phytother Res pmid:25447838
Singh V et al. Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells. 2015 Eur J Nutr pmid:25408199
Tang AQ et al. Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3‑derived sphere-forming cells. 2015 Mol Med Rep pmid:25405327
Hu J et al. Protective effect of apigenin on ischemia/reperfusion injury of the isolated rat heart. 2015 Cardiovasc. Toxicol. pmid:25377428
Pereira C et al. Infusions of artichoke and milk thistle represent a good source of phenolic acids and flavonoids. 2015 Food Funct pmid:25367590
Hu XY et al. 5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma. 2015 Clin. Exp. Pharmacol. Physiol. pmid:25363523
Zhu Y et al. Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer. 2015 Mol Med Rep pmid:25351792
Liu J et al. Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2α. 2015 Mol Med Rep pmid:25334018
Morimoto Y et al. Apigenin as an anti-quinolone-resistance antibiotic. 2015 Int. J. Antimicrob. Agents pmid:26526895
Seo HS et al. Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. 2015 Biosci. Rep. pmid:26500281
Xia F et al. Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus. 2015 Appl. Environ. Microbiol. pmid:26475103
Li L et al. Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα. 2015 PLoS ONE pmid:26440524
Willenberg I et al. Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity. 2015 PLoS ONE pmid:26440517
Shukla S et al. Apigenin blocks IKKα activation and suppresses prostate cancer progression. 2015 Oncotarget pmid:26435478
Lakshmanan A et al. Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin. 2015 Oncotarget pmid:26397139
Shukla S et al. Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice. 2015 PLoS ONE pmid:26379052
Sun J et al. Chemical Constituents and Antibacterial Properties of Indocalamus latifolius McClure Leaves, the Packaging Material for "Zongzi". 2015 Molecules pmid:26343625
Fang J et al. Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1. 2015 Mol Med Rep pmid:26300442
Falcone Ferreyra ML et al. The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions. 2015 Plant Physiol. pmid:26269546
Gao R et al. Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. 2015 Biomed. Chromatogr. pmid:25042239
Nakamura K et al. Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. 2015 Biol. Pharm. Bull. pmid:25810454
Mrazek AA et al. Apigenin inhibits pancreatic stellate cell activity in pancreatitis. 2015 J. Surg. Res. pmid:25799526
Liu L et al. Characterization of the intestinal absorption of seven flavonoids from the flowers of Trollius chinensis using the Caco-2 cell monolayer model. 2015 PLoS ONE pmid:25789809
Ji P et al. Antiviral activity of Paulownia tomentosa against enterovirus 71 of hand, foot, and mouth disease. 2015 Biol. Pharm. Bull. pmid:25744451
Yuan Y et al. Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia. 2015 J Neuroinflammation pmid:25600517
Li KC et al. Apigenin-7-glycoside prevents LPS-induced acute lung injury via downregulation of oxidative enzyme expression and protein activation through inhibition of MAPK phosphorylation. 2015 Int J Mol Sci pmid:25590301
Huang H et al. effects of natural flavonoids on photosynthetic activity and cell integrity in Microcystis aeruginosa. 2015 Toxins (Basel) pmid:25584428
Gulluce M et al. Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genotoxic potency. 2015 Toxicol Ind Health pmid:23377117
Wright B et al. GRID and docking analyses reveal a molecular basis for flavonoid inhibition of Src family kinase activity. 2015 J. Nutr. Biochem. pmid:26140983
Chang X et al. Protective effect of apigenin on Freund's complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway. 2015 Chem. Biol. Interact. pmid:25935278
Zhang T et al. Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. 2015 Chem. Biol. Interact. pmid:25557508
Aslan E and Adem S In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. 2015 J. Biochem. Mol. Toxicol. pmid:25388478
Santos BL et al. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. 2015 Chem. Biol. Interact. pmid:26408079
Ratajewski M et al. Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. 2015 Toxicol. Lett. pmid:25455453
Sun H et al. Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling. 2015 J. Agric. Food Chem. pmid:26066637
Li H et al. Separation of vitexin-4″-O-glucoside and vitexin-2″-O-rhamnoside from hawthorn leaves extracts using macroporous resins. 2015 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:26562804
Zemanova L et al. Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment. 2015 J. Nat. Prod. pmid:26529431
Shi ZH et al. Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. 2015 Eur J Med Chem pmid:26523667
Kang H et al. Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo. 2015 Inflamm. Res. pmid:26482935
Bhardwaj M et al. Potential role of vitexin in alleviating heat stress-induced cytotoxicity: Regulatory effect of Hsp90 on ER stress-mediated autophagy. 2015 Life Sci. pmid:26475763
Seo WD et al. Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5. 2015 Bioorg. Med. Chem. Lett. pmid:26471090
Lin CH et al. Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-κB pathways in human lung epithelial cells. 2015 Eur. J. Pharmacol. pmid:26463037
Shi ZH et al. Synthesis of scutellarein derivatives to increase biological activity and water solubility. 2015 Bioorg. Med. Chem. pmid:26455656
Zhang X et al. Stable knock-down of efflux transporters leads to reduced glucuronidation in UGT1A1-overexpressing HeLa cells: the evidence for glucuronidation-transport interplay. 2015 Mol. Pharm. pmid:25741749
Zhan YY et al. Inhibitory Effect of Apigenin on Pharmacokinetics of Venlafaxine in vivo and in vitro. 2015 Pharmacology pmid:26202346
Min JW et al. Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. 2015 Neuropharmacology pmid:26187393
Hong H et al. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. 2015 Toxicol. Sci. pmid:25349334
Ma GY et al. Comparison of inhibition capability of scutellarein and scutellarin towards important liver UDP-glucuronosyltransferase (UGT) isoforms. 2014 Phytother Res pmid:23620377
Hsu CW et al. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. 2014 Sci Rep pmid:25257666
Barlas N et al. The estrogenic effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar albino rats. 2014 Toxicol. Lett. pmid:24487097
Zhang X et al. Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. 2014 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:25289789
Chen T et al. Preparation of two flavonoid glycosides with unique structures from barley seedlings by membrane separation technology and preparative high-performance liquid chromatography. 2014 J Sep Sci pmid:25283274
Wei Y et al. Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles. 2014 Int J Pharm pmid:25269007
Jones MD et al. Investigating sub-2 μm particle stationary phase supercritical fluid chromatography coupled to mass spectrometry for chemical profiling of chamomile extracts. 2014 Anal. Chim. Acta pmid:25261902
Song HP et al. Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC-MS combined with enzyme channel blocking. 2014 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:24861872
Zheng CJ et al. Antiinflammatory effects and chemical constituents of Veronicastrum axillare. 2014 Phytother Res pmid:24817590
Chen J et al. The apoptotic effect of apigenin on human gastric carcinoma cells through mitochondrial signal pathway. 2014 Tumour Biol. pmid:24805829
Ali F et al. Protective effect of apigenin against N-nitrosodiethylamine (NDEA)-induced hepatotoxicity in albino rats. 2014 Mutat Res Genet Toxicol Environ Mutagen pmid:24755254
Abd-Alla MH et al. Rhizobium tibeticum activated with a mixture of flavonoids alleviates nickel toxicity in symbiosis with fenugreek (Trigonella foenum graecum L.). 2014 Ecotoxicology pmid:24740320
Islam MN et al. Vicenin 2 isolated from Artemisia capillaris exhibited potent anti-glycation properties. 2014 Food Chem. Toxicol. pmid:24713265
Singh G et al. Treatment of dermatophytosis by a new antifungal agent 'apigenin'. 2014 Mycoses pmid:24708558
Peng H et al. Simultaneous separation of apigenin, luteolin and rosmarinic acid from the aerial parts of the copper-tolerant plant Elsholtzia splendens. 2014 Environ Sci Pollut Res Int pmid:24671394
Wang H et al. Microwave-assisted simultaneous extraction of luteolin and apigenin from tree peony pod and evaluation of its antioxidant activity. 2014 ScientificWorldJournal pmid:25405227
Paramaguru R et al. Antidiabetic activity of Pterospermum acerifolium flowers and glucose uptake potential of bioactive fraction in L6 muscle cell lines with its HPLC fingerprint. 2014 Biomed Res Int pmid:25401101
Zhang M et al. Comparison of flavonoid compounds in the flavedo and juice of two pummelo cultivars (Citrus grandis L. Osbeck) from different cultivation regions in China. 2014 Molecules pmid:25353383
Mizuno H et al. Expression level of a flavonoid 3'-hydroxylase gene determines pathogen-induced color variation in sorghum. 2014 BMC Res Notes pmid:25346182
Zhang W et al. Apigenin inhibits enterovirus-71 infection by disrupting viral RNA association with trans-acting factors. 2014 PLoS ONE pmid:25330384
Zhou H et al. Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats. 2014 Molecules pmid:25268717
Zhang X et al. Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages. 2014 PLoS ONE pmid:25192391
Liu LH et al. Induction of apoptosis by VB1 in breast cancer cells: the role of reactive oxygen species and Bcl-2 family proteins. 2014 Int. J. Mol. Med. pmid:24276280
Shukla S et al. Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway. 2014 Carcinogenesis pmid:24067903
Lakshmanan A et al. Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells. 2014 Thyroid pmid:24400871
Kuo CH et al. Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils. 2014 J Ethnopharmacol pmid:24374236
Wang J et al. Purified vitexin compound 1 inhibits growth and angiogenesis through activation of FOXO3a by inactivation of Akt in hepatocellular carcinoma. 2014 Int. J. Mol. Med. pmid:24337611
Wang QQ et al. Synthesis, nitric oxide release, and α-glucosidase inhibition of nitric oxide donating apigenin and chrysin derivatives. 2014 Bioorg. Med. Chem. pmid:24508143
Yu XX et al. Isolation and purification of orientin and vitexin from Trollius chinensis Bunge by high-speed counter-current chromatography. 2014 Nat. Prod. Res. pmid:24650293
Tang H et al. Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats. 2014 Pharmacol. Biochem. Behav. pmid:24423938
Zhang F et al. Neuroprotective effect of apigenin in rats after contusive spinal cord injury. 2014 Neurol. Sci. pmid:24166720
Ozkan G and Ozcan MM Some phenolic compounds of extracts obtained from Origanum species growing in Turkey. 2014 Environ Monit Assess pmid:24691738
Jin H et al. Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II. 2014 Fitoterapia pmid:24468190