| MeSH term | MeSH ID | Detail |
|---|---|---|
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Palacz-Wrobel M et al. | Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages. | 2017 | Biomed. Pharmacother. | pmid:28738536 |
| Wang M et al. | Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus. | 2017 | Molecules | pmid:28771188 |
| Chen L et al. | Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. | 2017 | Arch Gerontol Geriatr | pmid:28743056 |
| Gao C et al. | Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. | 2017 | Oncol. Rep. | pmid:28737827 |
| Wang F et al. | Vitexin alleviates lipopolysaccharide‑induced islet cell injury by inhibiting HMGB1 release. | 2017 | Mol Med Rep | pmid:28098903 |
| Wu CC et al. | Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin. | 2017 | J. Biomed. Sci. | pmid:28056971 |
| Molina Prats P et al. | The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis - a pilot study using a Syrian hamster model. | 2017 | J. Oral Pathol. Med. | pmid:27378179 |
| Zhao T et al. | Novel apigenin-loaded sodium hyaluronate nano-assemblies for targeting tumor cells. | 2017 | Carbohydr Polym | pmid:28962787 |
| Liu Y et al. | Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway. | 2017 | Biomed. Pharmacother. | pmid:28962085 |
| Wu Y et al. | Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase. | 2017 | Neurochem. Int. | pmid:28947342 |
| Lee JA et al. | Effects of friedelin on the intestinal permeability and bioavailability of apigenin. | 2017 | Pharmacol Rep | pmid:28939344 |
| Adaszyńska-Skwirzyńska M and Dzięcioł M | Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. | 2017 | Nat. Prod. Res. | pmid:28449600 |
| Mohammad F E et al. | Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. | 2017 | J. Biochem. Mol. Toxicol. | pmid:28422384 |
| Feng X et al. | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Biochem. Pharmacol. | pmid:28414138 |
| Li G et al. | Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28408212 |
| Wu W et al. | Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. | 2017 | Drug Dev Ind Pharm | pmid:28402147 |
| Sheeja Malar D et al. | Cholinesterase inhibitory, anti-amyloidogenic and neuroprotective effect of the medicinal plant Grewia tiliaefolia - An in vitro and in silico study. | 2017 | Pharm Biol | pmid:27931177 |
| Ganai SA | Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer. | 2017 | Biomed. Pharmacother. | pmid:27930986 |
| Oliveira KG et al. | Effect of the storage time and temperature on phenolic compounds of sorghum grain and flour. | 2017 | Food Chem | pmid:27596435 |
| Hwang SH et al. | Simultaneous Ultra Performance Liquid Chromatography Determination and Antioxidant Activity of Linarin, Luteolin, Chlorogenic Acid and Apigenin in Different Parts of Compositae Species. | 2016 | Molecules | pmid:27886116 |
| Lee SW et al. | Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis. | 2016 | PLoS ONE | pmid:27851782 |
| BasÃlio N et al. | Analogs of Natural 3-Deoxyanthocyanins: O-Glucosides of the 4',7-Dihydroxyflavylium Ion and the Deep Influence of Glycosidation on Color. | 2016 | Int J Mol Sci | pmid:27775619 |
| Li Y et al. | Pharmacokinetic Comparison of Scutellarin and Paeoniflorin in Sham-Operated and Middle Cerebral Artery Occlusion Ischemia and Reperfusion Injury Rats after Intravenous Administration of Xin-Shao Formula. | 2016 | Molecules | pmid:27617986 |
| Sun C et al. | Rapid Isolation and Determination of Flavones in Biological Samples Using Zinc Complexation Coupled with High-Performance Liquid Chromatography. | 2016 | Molecules | pmid:27537870 |
| Wang H et al. | Engineering Saccharomyces cerevisiae with the deletion of endogenous glucosidases for the production of flavonoid glucosides. | 2016 | Microb. Cell Fact. | pmid:27491546 |
| Hu Y et al. | Synthetic investigation toward apigenin 5-O-glycoside camellianin B as well as the chemical structure revision. | 2016 | Org. Biomol. Chem. | pmid:27145917 |
| Hawrył A et al. | TLC Profiles of Selected Cirsium Species with Chemometrics in Construction of Their Fingerprints. | 2016 | J Chromatogr Sci | pmid:27130878 |
| Yuan Y et al. | Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia. | 2016 | Neuromolecular Med. | pmid:27103430 |
| Tian X et al. | Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C. | 2016 | Biol. Pharm. Bull. | pmid:26581323 |
| Li X et al. | Apigenin, a potent suppressor of dendritic cell maturation and migration, protects against collagen-induced arthritis. | 2016 | J. Cell. Mol. Med. | pmid:26515512 |
| Chen L et al. | Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways. | 2016 | Mol Med Rep | pmid:27878303 |
| Mendel M et al. | Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study. | 2016 | Animal | pmid:27534882 |
| Huang Y et al. | Preparation of inclusion complex of apigenin-hydroxypropyl-β-cyclodextrin by using supercritical antisolvent process for dissolution and bioavailability enhancement. | 2016 | Int J Pharm | pmid:27515291 |
| VeÄeÅ™ová K et al. | Changes of primary and secondary metabolites in barley plants exposed to CdO nanoparticles. | 2016 | Environ. Pollut. | pmid:27503055 |
| Qin W et al. | Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose. | 2016 | Vascul. Pharmacol. | pmid:27473516 |
| Aseervatham GS et al. | Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice. | 2016 | Biomed. Pharmacother. | pmid:27470339 |
| Kim BK et al. | Enhancing oral bioavailability using preparations of apigenin-loaded W/O/W emulsions: In vitro and in vivo evaluations. | 2016 | Food Chem | pmid:27041302 |
| Jiang Z et al. | Determination of scutellarin in breviscapine preparations using quantitative proton nuclear magnetic resonance spectroscopy. | 2016 | J Food Drug Anal | pmid:28911594 |
| Márquez-Flores YK et al. | Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways. | 2016 | J. Nutr. Biochem. | pmid:27012631 |
| Lee HE et al. | Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property. | 2016 | Behav. Brain Res. | pmid:26996316 |
| Zhu ZY et al. | Apigenin ameliorates hypertension-induced cardiac hypertrophy and down-regulates cardiac hypoxia inducible factor-lα in rats. | 2016 | Food Funct | pmid:26987380 |
| Lim W et al. | Apigenin Reduces Survival of Choriocarcinoma Cells by Inducing Apoptosis via the PI3K/AKT and ERK1/2 MAPK Pathways. | 2016 | J. Cell. Physiol. | pmid:26970256 |
| Basios N et al. | Apigenin Attenuates Inflammation in Experimentally Induced Acute Pancreatitis-Associated Lung Injury. | 2016 | J Invest Surg | pmid:26631908 |
| Lee IC and Bae JS | Anti-inflammatory effects of vicenin-2 and scolymoside on polyphosphate-mediated vascular inflammatory responses. | 2016 | Inflamm. Res. | pmid:26621502 |
| Lou SN et al. | Phenolic content, antioxidant activity and effective compounds of kumquat extracted by different solvents. | 2016 | Food Chem | pmid:26616917 |
| Mostafa NM et al. | Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae). | 2016 | Nat. Prod. Res. | pmid:26594904 |
| Kawamura H et al. | Ultrasonically enhanced extraction of luteolin and apigenin from the leaves of Perilla frutescens (L.) Britt. using liquid carbon dioxide and ethanol. | 2016 | Ultrason Sonochem | pmid:26584980 |
| Lee YM et al. | Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress. | 2016 | Int. J. Oncol. | pmid:26573871 |
| Zou H et al. | Two new flavonoids from Selaginella uncinata. | 2016 | J Asian Nat Prod Res | pmid:26238803 |
| KubÃnová R et al. | Anticholinesterase, antioxidant activity and phytochemical investigation into aqueous extracts from five species of Agrimonia genus. | 2016 | Nat. Prod. Res. | pmid:26235662 |