| MeSH term | MeSH ID | Detail |
|---|---|---|
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abdelhady MI et al. | Bioassay-guided isolation and POM analyses of a new immunomodulatory polyphenolic constituent from Callistemon viridiflorus. | 2016 | Nat. Prod. Res. | pmid:26156551 |
| Veltmann M et al. | Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. | 2016 | PLoS ONE | pmid:26800359 |
| Qin Y et al. | Apigenin inhibits NF-κB and snail signaling, EMT and metastasis in human hepatocellular carcinoma. | 2016 | Oncotarget | pmid:27203387 |
| Hu Y et al. | Synthetic investigation toward apigenin 5-O-glycoside camellianin B as well as the chemical structure revision. | 2016 | Org. Biomol. Chem. | pmid:27145917 |
| Hawrył A et al. | TLC Profiles of Selected Cirsium Species with Chemometrics in Construction of Their Fingerprints. | 2016 | J Chromatogr Sci | pmid:27130878 |
| Yuan Y et al. | Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia. | 2016 | Neuromolecular Med. | pmid:27103430 |
| Cardenas H et al. | Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function. | 2016 | Int J Mol Sci | pmid:26938530 |
| GarcÃa-MartÃnez O et al. | Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation. | 2016 | PLoS ONE | pmid:26930190 |
| Dong ZX et al. | An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin. | 2016 | Molecules | pmid:26927039 |
| Cao HH et al. | Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma. | 2016 | Sci Rep | pmid:26911838 |
| Wu G et al. | Growth temperature and genotype both play important roles in sorghum grain phenolic composition. | 2016 | Sci Rep | pmid:26907726 |
| Bridgeman BB et al. | Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention. | 2016 | Cell. Signal. | pmid:26876613 |
| Verma S et al. | Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations. | 2016 | PLoS ONE | pmid:26863418 |
| Fonseca-Silva F et al. | Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action. | 2016 | PLoS Negl Trop Dis | pmid:26862901 |
| Zhu Q et al. | Antinociceptive effects of vitexin in a mouse model of postoperative pain. | 2016 | Sci Rep | pmid:26763934 |
| Asanagi M et al. | Tributyltin induces G2/M cell cycle arrest via NAD(+)-dependent isocitrate dehydrogenase in human embryonic carcinoma cells. | 2016 | J Toxicol Sci | pmid:26961604 |
| Ginwala R et al. | Apigenin, a Natural Flavonoid, Attenuates EAE Severity Through the Modulation of Dendritic Cell and Other Immune Cell Functions. | 2016 | J Neuroimmune Pharmacol | pmid:26040501 |
| Kim B et al. | Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling. | 2016 | Phytother Res | pmid:27468969 |
| Yagishita Y et al. | Photochromic Properties of 3-Deoxyanthocyanidin Pigments in Nontoxic Solvents. | 2016 | J. Food Sci. | pmid:27925261 |
| Chen L et al. | Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways. | 2016 | Mol Med Rep | pmid:27878303 |
| Erdogan S et al. | The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling. | 2016 | Life Sci. | pmid:27569589 |
| Mendel M et al. | Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study. | 2016 | Animal | pmid:27534882 |
| Huang Y et al. | Preparation of inclusion complex of apigenin-hydroxypropyl-β-cyclodextrin by using supercritical antisolvent process for dissolution and bioavailability enhancement. | 2016 | Int J Pharm | pmid:27515291 |
| VeÄeÅ™ová K et al. | Changes of primary and secondary metabolites in barley plants exposed to CdO nanoparticles. | 2016 | Environ. Pollut. | pmid:27503055 |
| Qin W et al. | Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose. | 2016 | Vascul. Pharmacol. | pmid:27473516 |
| Aseervatham GS et al. | Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice. | 2016 | Biomed. Pharmacother. | pmid:27470339 |
| Salami M et al. | Inhibitory effect of different fennel (Foeniculum vulgare) samples and their phenolic compounds on formation of advanced glycation products and comparison of antimicrobial and antioxidant activities. | 2016 | Food Chem | pmid:27451172 |
| Liu L et al. | Luteolin and apigenin activate the Oct-4/Sox2 signal via NFATc1 in human periodontal ligament cells. | 2016 | Cell Biol. Int. | pmid:27449921 |
| Pan G et al. | Total synthesis of 8-(6″-umbelliferyl)-apigenin and its analogs as anti-diabetic reagents. | 2016 | Eur J Med Chem | pmid:27448923 |
| Dubois N et al. | Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential. | 2016 | Int. J. Oncol. | pmid:27098015 |
| Simeonova R et al. | Antidiabetic and antioxidant effects of saponarin from Gypsophila trichotoma on streptozotocin-induced diabetic normotensive and hypertensive rats. | 2016 | Phytomedicine | pmid:27064007 |
| Kim BK et al. | Enhancing oral bioavailability using preparations of apigenin-loaded W/O/W emulsions: In vitro and in vivo evaluations. | 2016 | Food Chem | pmid:27041302 |
| Jiang Z et al. | Determination of scutellarin in breviscapine preparations using quantitative proton nuclear magnetic resonance spectroscopy. | 2016 | J Food Drug Anal | pmid:28911594 |
| Márquez-Flores YK et al. | Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways. | 2016 | J. Nutr. Biochem. | pmid:27012631 |
| Lee HE et al. | Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property. | 2016 | Behav. Brain Res. | pmid:26996316 |
| Zhu ZY et al. | Apigenin ameliorates hypertension-induced cardiac hypertrophy and down-regulates cardiac hypoxia inducible factor-lα in rats. | 2016 | Food Funct | pmid:26987380 |
| Lim W et al. | Apigenin Reduces Survival of Choriocarcinoma Cells by Inducing Apoptosis via the PI3K/AKT and ERK1/2 MAPK Pathways. | 2016 | J. Cell. Physiol. | pmid:26970256 |
| Xiong Z et al. | Mushroom (Agaricus bisporus) polyphenoloxidase inhibited by apigenin: Multi-spectroscopic analyses and computational docking simulation. | 2016 | Food Chem | pmid:26948635 |
| Romero GB et al. | Simple low-cost miniaturization approach for pharmaceutical nanocrystals production. | 2016 | Int J Pharm | pmid:26642945 |
| Basios N et al. | Apigenin Attenuates Inflammation in Experimentally Induced Acute Pancreatitis-Associated Lung Injury. | 2016 | J Invest Surg | pmid:26631908 |
| Lee IC and Bae JS | Anti-inflammatory effects of vicenin-2 and scolymoside on polyphosphate-mediated vascular inflammatory responses. | 2016 | Inflamm. Res. | pmid:26621502 |
| Lou SN et al. | Phenolic content, antioxidant activity and effective compounds of kumquat extracted by different solvents. | 2016 | Food Chem | pmid:26616917 |
| Mostafa NM et al. | Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae). | 2016 | Nat. Prod. Res. | pmid:26594904 |
| Kawamura H et al. | Ultrasonically enhanced extraction of luteolin and apigenin from the leaves of Perilla frutescens (L.) Britt. using liquid carbon dioxide and ethanol. | 2016 | Ultrason Sonochem | pmid:26584980 |
| Lee YM et al. | Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress. | 2016 | Int. J. Oncol. | pmid:26573871 |
| Cochran DB et al. | Degradable poly(apigenin) polymer inhibits tumor cell adhesion to vascular endothelial cells. | 2016 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:26251070 |
| Zou H et al. | Two new flavonoids from Selaginella uncinata. | 2016 | J Asian Nat Prod Res | pmid:26238803 |
| KubÃnová R et al. | Anticholinesterase, antioxidant activity and phytochemical investigation into aqueous extracts from five species of Agrimonia genus. | 2016 | Nat. Prod. Res. | pmid:26235662 |
| Iqbal MK et al. | Recovery of Chicken Growth Plate by Heat-Shock Protein 90 Inhibitors Epigallocatechin-3-Gallate and Apigenin in Thiram-Induced Tibial Dyschondroplasia. | 2016 | Avian Dis. | pmid:27902918 |
| Buwa CC et al. | Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System. | 2016 | Cardiovasc. Toxicol. | pmid:26186996 |