| MeSH term | MeSH ID | Detail |
|---|---|---|
| Encephalitis | D004660 | 15 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Cocaine-Related Disorders | D019970 | 3 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Griffith AP and Collison MW | Improved methods for the extraction and analysis of isoflavones from soy-containing foods and nutritional supplements by reversed-phase high-performance liquid chromatography and liquid chromatography-mass spectrometry. | 2001 | J Chromatogr A | pmid:11355838 |
| Ricupero DA et al. | Apigenin decreases expression of the myofibroblast phenotype. | 2001 | FEBS Lett. | pmid:11591363 |
| Gupta S et al. | Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573952 |
| Witte MC et al. | Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry. | 2001 | Eur. J. Neurosci. | pmid:11576187 |
| Boveris AD et al. | Antioxidant capacity of a 3-deoxyanthocyanidin from soybean. | 2001 | Phytochemistry | pmid:11730874 |
| Neff L et al. | NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci. | 2001 | Cell. Microbiol. | pmid:11580755 |
| Lindenmeyer F et al. | Apigenin acts on the tumor cell invasion process and regulates protease production. | 2001 | Nutr Cancer | pmid:11588896 |
| Stochmal A et al. | Acylated apigenin glycosides from alfalfa (Medicago sativa L.) var. Artal. | 2001 | Phytochemistry | pmid:11454348 |
| Gobbi M et al. | In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. | 2001 | Pharmacopsychiatry | pmid:11518075 |
| Aquino R et al. | Phenolic constituents and antioxidant activity of an extract of Anthuriumversicolor leaves. | 2001 | J. Nat. Prod. | pmid:11520218 |
| Kyriakopoulou I et al. | Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia. | 2001 | J. Nat. Prod. | pmid:11520237 |
| Martens S et al. | Cloning of parsley flavone synthase I. | 2001 | Phytochemistry | pmid:11524111 |
| Qu J et al. | Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry. | 2001 | J Chromatogr A | pmid:11587333 |
| Yin F et al. | Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. | 2001 Jan-Feb | Anticancer Res. | pmid:11299771 |
| Bylka W | Isovitexin o-glucosides from Aquilegia vulgaris L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693732 |
| Matławska I | Flavonoid compounds in the flowers of Kitaibelia vitifolia Willd. (Malvaceae). | 2001 Mar-Apr | Acta Pol Pharm | pmid:11501790 |
| Kim HR et al. | Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A2. | 2001 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11993721 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Nagao T et al. | Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. | 2002 | Biol. Pharm. Bull. | pmid:12132661 |
| Brantner AH et al. | HET-CAM bioassay as in vitro alternative to the croton oil test for investigating steroidal and non-steroidal compounds. | 2002 | ALTEX | pmid:12098009 |
| Lorentz A et al. | Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins. | 2002 | Blood | pmid:11807000 |
| Li J and Chen YT | [Two flavonoids from Lagopsis supina]. | 2002 | Yao Xue Xue Bao | pmid:12579758 |
| Liu H et al. | [Study on effects of scutellarin on scavenging reactive oxygen]. | 2002 | Zhong Yao Cai | pmid:12599762 |
| Han DH et al. | Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224631 |
| Agati G et al. | Flavonoid distribution in tissues of Phillyrea latifolia L. leaves as estimated by microspectrofluorometry and multispectral fluorescence microimaging. | 2002 | Photochem. Photobiol. | pmid:12403458 |
| Miro FA et al. | Persistent nuclear accumulation of protein kinase CK2 during the G1-phase of the cell cycle does not depend on the ERK1/2 pathway but requires active protein synthesis. | 2002 | Arch. Biochem. Biophys. | pmid:12361704 |
| Zétola M et al. | CNS activities of liquid and spray-dried extracts from Lippia alba-Verbenaceae (Brazilian false melissa). | 2002 | J Ethnopharmacol | pmid:12241997 |
| Lee S et al. | Phytochemical constituents from the herba of Artemisia apiacea. | 2002 | Arch. Pharm. Res. | pmid:12135098 |
| Prescott AG et al. | In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana. | 2002 | Phytochemistry | pmid:12126705 |
| Liu Y and Hu M | Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. | 2002 | Drug Metab. Dispos. | pmid:11901089 |
| Exarchou V et al. | Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory. | 2002 | J. Agric. Food Chem. | pmid:12207464 |
| Snyder RD and Gillies PJ | Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells. | 2002 | Environ. Mol. Mutagen. | pmid:12489117 |
| Mastuda H et al. | Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells. | 2002 | Bioorg. Med. Chem. | pmid:12150856 |
| Walle UK and Walle T | Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements. | 2002 | Drug Metab. Dispos. | pmid:11950788 |
| Lu J et al. | Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils. | 2002 | Clin. Chim. Acta | pmid:11750278 |
| Cao Y et al. | Analysis of flavonoids in Ginkgo biloba L. and its phytopharmaceuticals by capillary electrophoresis with electrochemical detection. | 2002 | Anal Bioanal Chem | pmid:12324852 |
| Tsuchiya H et al. | Membrane-rigidifying effects of anti-cancer dietary factors. | 2002 | Biofactors | pmid:14530593 |
| Couladis M et al. | Antioxidant activity of polyphenols from Hypericum triquetrifolium Turra. | 2002 | Phytother Res | pmid:12458485 |
| Bito T et al. | Flavonoids differentially regulate IFN gamma-induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action. | 2002 | FEBS Lett. | pmid:12044887 |
| Ma T et al. | High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. | 2002 | J. Biol. Chem. | pmid:12161441 |
| Sampson L et al. | Flavonol and flavone intakes in US health professionals. | 2002 | J Am Diet Assoc | pmid:12396158 |
| Frangne N et al. | Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. | 2002 | Plant Physiol. | pmid:11842175 |
| Afaq F et al. | Botanical antioxidants for chemoprevention of photocarcinogenesis. | 2002 | Front. Biosci. | pmid:11897547 |
| Llorens F et al. | Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation. | 2002 | FEBS Lett. | pmid:11801244 |
| McVean M et al. | A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin. | 2002 | Mol. Carcinog. | pmid:11807956 |
| Marder M and Paladini AC | GABA(A)-receptor ligands of flavonoid structure. | 2002 | Curr Top Med Chem | pmid:12171576 |
| Grayer RJ et al. | Scutellarein 4'-methyl ether glycosides as taxonomic markers in Teucridium and Tripora (Lamiaceae, Ajugoideae). | 2002 | Phytochemistry | pmid:12127590 |
| Gil-Izquierdo A et al. | Effect of processing techniques at industrial scale on orange juice antioxidant and beneficial health compounds. | 2002 | J. Agric. Food Chem. | pmid:12188615 |
| Kim TJ et al. | Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells. | 2002 | Planta Med. | pmid:12142993 |
| Aboutabl EA et al. | Phytochemical and pharmacological studies on Sideritis taurica Stephan ex Wild. | 2002 | J Ethnopharmacol | pmid:12241993 |