MeSH term | MeSH ID | Detail |
---|---|---|
Colonic Neoplasms | D003110 | 161 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Jiang PY et al. | Protective effects of apigenin on LPS-induced endometritis via activating Nrf2 signaling pathway. | 2018 | Microb. Pathog. | pmid:29928944 |
Zhou Z et al. | Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway. | 2018 | Mol Med Rep | pmid:29901074 |
Yang D et al. | Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line. | 2018 | Drug Des Devel Ther | pmid:29849451 |
Bhattacharya S et al. | Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats. | 2018 | Nanomedicine | pmid:29802937 |
Gu CB et al. | Characterization, culture medium optimization and antioxidant activity of an endophytic vitexin-producing fungus Dichotomopilus funicola Y3 from pigeon pea [Cajanus cajan (L.) Millsp.]. | 2018 | J. Appl. Microbiol. | pmid:29791772 |
Wu TC et al. | Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. | 2018 | Chem. Biol. Interact. | pmid:30016632 |
Lim H et al. | Flavonoids interfere with NLRP3 inflammasome activation. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29960001 |
Gentile D et al. | The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. | 2018 | PLoS ONE | pmid:29641549 |
Kalogiouri NP et al. | Application of an advanced and wide scope non-target screening workflow with LC-ESI-QTOF-MS and chemometrics for the classification of the Greek olive oil varieties. | 2018 | Food Chem | pmid:29606472 |
Hu WJ et al. | Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling. | 2018 | Biomed. Pharmacother. | pmid:29604587 |
Hu M et al. | Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway. | 2018 | Drug Des Devel Ther | pmid:29588573 |
Elhennawy MG and Lin HS | Dose- and time-dependent pharmacokinetics of apigenin trimethyl ether. | 2018 | Eur J Pharm Sci | pmid:29574080 |
Yang B et al. | Pharmacokinetic comparison of seven major bioactive components in normal and depression model rats after oral administration of Baihe Zhimu decoction by liquid chromatography-tandem mass spectrometry. | 2018 | J Pharm Biomed Anal | pmid:28987996 |
Zhong Y et al. | Protective effects of apigenin against 3-MCPD-induced renal injury in rat. | 2018 | Chem. Biol. Interact. | pmid:30107153 |
Kowalczyk A et al. | Insights into novel anticancer applications for apigenin. | 2017 | Adv Clin Exp Med | pmid:29211364 |
Palacz-Wrobel M et al. | Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages. | 2017 | Biomed. Pharmacother. | pmid:28738536 |
Pate KM et al. | Anthoxanthin Polyphenols Attenuate Aβ Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease. | 2017 | CNS Neurosci Ther | pmid:27864869 |
Gao C et al. | Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. | 2017 | Oncol. Rep. | pmid:28737827 |
Ghazanfar K et al. | Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. | 2017 | J Complement Integr Med | pmid:28731312 |
Jin X et al. | Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. | 2017 | Int J Nanomedicine | pmid:28761344 |
Sun Y et al. | Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. | 2017 | Molecules | pmid:28696360 |
Gu T et al. | Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative. | 2017 | Molecules | pmid:28635646 |
Seo HS et al. | Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. | 2017 | Oncol. Rep. | pmid:28656316 |
Nurdiana S et al. | Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. | 2017 | BMC Complement Altern Med | pmid:28576138 |
Spilovska K et al. | Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. | 2017 | Molecules | pmid:28621747 |
Bauer D et al. | Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. | 2017 | PLoS ONE | pmid:28441391 |
Salmani JMM et al. | Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives. | 2017 | Chin J Nat Med | pmid:28558867 |
Meng S et al. | Apigenin inhibits renal cell carcinoma cell proliferation. | 2017 | Oncotarget | pmid:28423637 |
Elmasri WA et al. | Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization. | 2017 | J. Proteome Res. | pmid:28541047 |
Mahajan UB et al. | The Protective Effect of Apigenin on Myocardial Injury in Diabetic Rats mediating Activation of the PPAR-γ Pathway. | 2017 | Int J Mol Sci | pmid:28375162 |
Yang PM et al. | Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. | 2017 | Oncotarget | pmid:28526810 |
Zhong Y et al. | Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. | 2017 | Toxicon | pmid:28734981 |
Wang J et al. | Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy. | 2017 | J Nanobiotechnology | pmid:28249594 |
Elhennawy MG and Lin HS | Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. | 2017 | J Pharm Biomed Anal | pmid:28494337 |
Souza RP et al. | Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines. | 2017 | Oxid Med Cell Longev | pmid:28191273 |
Alvin JW and Lacy DB | Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. | 2017 | J. Struct. Biol. | pmid:28433497 |
Hicks DF et al. | Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. | 2017 | Sci Rep | pmid:28256512 |
Nelson N et al. | Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer. | 2017 | PLoS ONE | pmid:28152014 |
Min JW et al. | Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. | 2017 | Oncotarget | pmid:28424420 |
Wang F et al. | Vitexin alleviates lipopolysaccharide‑induced islet cell injury by inhibiting HMGB1 release. | 2017 | Mol Med Rep | pmid:28098903 |
Wu CC et al. | Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin. | 2017 | J. Biomed. Sci. | pmid:28056971 |
Perrott KM et al. | Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. | 2017 | Geroscience | pmid:28378188 |
Stump TA et al. | The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. | 2017 | J. Pharm. Pharmacol. | pmid:28349530 |
Sun XP et al. | Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. | 2017 | Arch. Pharm. Res. | pmid:28315259 |
Ferrazzi P et al. | Pollination effects on antioxidant content of Perilla frutescens seeds analysed by NMR spectroscopy. | 2017 | Nat. Prod. Res. | pmid:28278651 |
Molina Prats P et al. | The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis - a pilot study using a Syrian hamster model. | 2017 | J. Oral Pathol. Med. | pmid:27378179 |
Naik PM and Al-Khayri JM | Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. | 2017 | Methods Mol. Biol. | pmid:28755356 |
Grigalius I and Petrikaite V | Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. | 2017 | Molecules | pmid:29215574 |
Granato M et al. | Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. | 2017 | J. Exp. Clin. Cancer Res. | pmid:29179721 |
Fan H et al. | Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. | 2017 | Med. Sci. Monit. | pmid:29172017 |
Liao M et al. | Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29127056 |
Medhat AM et al. | Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. | 2017 | Tumour Biol. | pmid:29022496 |
Ganesan K and Xu B | Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. | 2017 | Ann. N. Y. Acad. Sci. | pmid:28891090 |
Zhou RJ et al. | Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28867192 |
Shan S et al. | Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. | 2017 | J. Agric. Food Chem. | pmid:28829588 |
Britto SM et al. | Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. | 2017 | Mutat. Res. | pmid:28735741 |
Wen L et al. | An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. | 2017 | Molecules | pmid:28486427 |
Jangdey MS et al. | Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. | 2017 | Drug Deliv | pmid:28687053 |
Wu Y et al. | Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase. | 2017 | Neurochem. Int. | pmid:28947342 |
Lee JA et al. | Effects of friedelin on the intestinal permeability and bioavailability of apigenin. | 2017 | Pharmacol Rep | pmid:28939344 |
Tamayose CI et al. | Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. | 2017 | Int J Mol Sci | pmid:28906474 |
Zhang L et al. | Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. | 2017 | Mol Med Rep | pmid:28849116 |
Tu F et al. | Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. | 2017 | Med. Sci. Monit. | pmid:28821706 |
Liu S and Ho PC | Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. | 2017 | J. Pharm. Pharmacol. | pmid:28809432 |
Fallatah O and Georges E | Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. | 2017 | Int. J. Antimicrob. Agents | pmid:28807879 |
Che Ahmad Tantowi NA et al. | Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. | 2017 | Menopause | pmid:28640163 |
Li G et al. | Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28408212 |
Li J et al. | Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. | 2017 | World J. Gastroenterol. | pmid:28611514 |
Wu W et al. | Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. | 2017 | Drug Dev Ind Pharm | pmid:28402147 |
Chen JL and Ko WC | Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. | 2017 | Eur. J. Pharmacol. | pmid:28603044 |
Wan Y et al. | miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. | 2017 | Tumour Biol. | pmid:28381178 |
Singhal SS et al. | Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. | 2017 | Biochim Biophys Acta Rev Cancer | pmid:28359741 |
Zhang Z et al. | Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. | 2017 | Drug Dev Ind Pharm | pmid:28358225 |
Karim R et al. | Development and evaluation of injectable nanosized drug delivery systems for apigenin. | 2017 | Int J Pharm | pmid:28456651 |
Han Y et al. | Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. | 2017 | J Clin Neurosci | pmid:28342702 |
Bian M et al. | Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. | 2017 | Brain Res. | pmid:28336272 |
Crascì L et al. | Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. | 2017 | Planta Med. | pmid:28288492 |
Zhang S et al. | Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation. | 2017 | Mol. Immunol. | pmid:28288411 |
Zhao G et al. | Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. | 2017 | Oncol. Rep. | pmid:28260058 |
Bolzon LB et al. | Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems. | 2017 | J. Inorg. Biochem. | pmid:28236787 |
Liu HJ et al. | Apigenin alleviates STZ-induced diabetic cardiomyopathy. | 2017 | Mol. Cell. Biochem. | pmid:28176247 |
Maher HM et al. | Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS. | 2017 | J Pharm Biomed Anal | pmid:28167419 |
Wei X et al. | Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. | 2017 | Clin. Sci. | pmid:28143892 |
Espargaró A et al. | Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. | 2017 | J. Nat. Prod. | pmid:28128562 |
Zhou Z et al. | Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. | 2017 | Anticancer Drugs | pmid:28125432 |
Erdogan S et al. | The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. | 2017 | Biomed. Pharmacother. | pmid:28107698 |
Thirusangu P et al. | Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28104392 |
Hithamani G et al. | Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells. | 2017 | J. Biosci. | pmid:29229878 |
Zou Z et al. | Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii. | 2017 | Fitoterapia | pmid:27889540 |
Zou Z et al. | Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. | 2017 | Phytochemistry | pmid:27889245 |
Ketkaew Y et al. | Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. | 2017 | Arch. Oral Biol. | pmid:27886571 |
Liu H et al. | Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. | 2017 | J Chromatogr Sci | pmid:27884870 |
Wu CY et al. | Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration. | 2017 | Curr. Med. Chem. | pmid:27855618 |
Guo TT et al. | Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. | 2017 | J Asian Nat Prod Res | pmid:27848262 |
Sharma N et al. | Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativus Targeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena. | 2017 | Med Chem | pmid:27834134 |
Tang D et al. | Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. | 2017 | Expert Opin Drug Metab Toxicol | pmid:27766890 |
Lecomte S et al. | Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28396216 |
Wen L et al. | Identification of a flavonoid C-glycoside as potent antioxidant. | 2017 | Free Radic. Biol. Med. | pmid:28587909 |
Wong TY et al. | Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. | 2017 | Biomed. Pharmacother. | pmid:29198743 |
Salazar-Aguilar S et al. | Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. | 2017 | Nutrients | pmid:28757593 |