MeSH term | MeSH ID | Detail |
---|---|---|
Colonic Neoplasms | D003110 | 161 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Stroheker T et al. | Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines. | 2004 | Food Chem. Toxicol. | pmid:15110097 |
Choi JS et al. | Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B. | 2004 | J. Nutr. | pmid:15113938 |
Gutierrez-Lugo MT et al. | Lipoxygenase inhibition by anadanthoflavone, a new flavonoid from the aerial parts of Anadenanthera colubrina. | 2004 | Planta Med. | pmid:15114507 |
Hong H and Liu GQ | Scutellarin attenuates oxidative glutamate toxicity in PC12 cells. | 2004 | Planta Med. | pmid:15124087 |
Uddin Q et al. | The biflavonoid, amentoflavone degrades DNA in the presence of copper ions. | 2004 | Toxicol In Vitro | pmid:15130600 |
Shukla S and Gupta S | Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes. | 2004 | Clin. Cancer Res. | pmid:15131058 |
Eltayeb AA et al. | Antagonistic effect of scutellarin on the toxicity of selenium in rat livers. | 2004 | Biol Trace Elem Res | pmid:15131321 |
Hwang BY et al. | Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. | 2004 | J. Org. Chem. | pmid:15132542 |
Kanchanapoom T et al. | Phenylethanoid and iridoid glycosides from the Thai medicinal plant, Barleria strigosa. | 2004 | Chem. Pharm. Bull. | pmid:15133217 |
Morimitsu Y et al. | Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. | 2004 | Biol. Pharm. Bull. | pmid:15133252 |
Butković V et al. | Kinetic study of flavonoid reactions with stable radicals. | 2004 | J. Agric. Food Chem. | pmid:15137819 |
Martins HF et al. | Toward the prediction of the activity of antioxidants: experimental and theoretical study of the gas-phase acidities of flavonoids. | 2004 | J. Am. Soc. Mass Spectrom. | pmid:15144974 |
Hirano T et al. | Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. | 2004 | Int. Arch. Allergy Immunol. | pmid:15153793 |
Tereschuk ML et al. | Flavonoids from Argentine Tagetes (Asteraceae) with antimicrobial activity. | 2004 | Methods Mol. Biol. | pmid:15156042 |
Singh JP et al. | Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats. | 2004 | Phytomedicine | pmid:15185843 |
Lim M et al. | Modulation of deltaF508 cystic fibrosis transmembrane regulator trafficking and function with 4-phenylbutyrate and flavonoids. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:15191910 |
Wang W et al. | Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines. | 2004 | Nutr Cancer | pmid:15203384 |
Schütz K et al. | Identification and quantification of caffeoylquinic acids and flavonoids from artichoke (Cynara scolymus L.) heads, juice, and pomace by HPLC-DAD-ESI/MS(n). | 2004 | J. Agric. Food Chem. | pmid:15212452 |
Klampfer L et al. | Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression. | 2004 | J. Biol. Chem. | pmid:15213223 |
Volpi N | Separation of flavonoids and phenolic acids from propolis by capillary zone electrophoresis. | 2004 | Electrophoresis | pmid:15213987 |
Chun OK et al. | Antioxidant properties of raw and processed cabbages. | 2004 | Int J Food Sci Nutr | pmid:15223595 |
O'Leary KA et al. | Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. | 2004 | Mutat. Res. | pmid:15225597 |
Fenton JI and Hord NG | Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity. | 2004 | Nutr Cancer | pmid:15231453 |
Kavvadias D et al. | The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. | 2004 | Br. J. Pharmacol. | pmid:15231642 |
Martini ND et al. | Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae). | 2004 | J Ethnopharmacol | pmid:15234754 |
Verbeek R et al. | The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. | 2004 | Biochem. Pharmacol. | pmid:15276069 |
Muanprasat C et al. | Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. | 2004 | J. Gen. Physiol. | pmid:15277574 |
von Moltke LL et al. | Inhibition of human cytochromes P450 by components of Ginkgo biloba. | 2004 | J. Pharm. Pharmacol. | pmid:15285849 |
Zhang S et al. | Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport. | 2004 | Pharm. Res. | pmid:15290869 |
Niisato N et al. | Involvement of cytosolic Cl- in osmoregulation of alpha-ENaC gene expression. | 2004 | Am. J. Physiol. Renal Physiol. | pmid:15292045 |
Jones DJ et al. | Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity. | 2004 | Br. J. Cancer | pmid:15292928 |
Jakstas V et al. | [Research of the amounts of flavonoids accumulated in the buds of single-styled hawthorn]. | 2004 | Medicina (Kaunas) | pmid:15299992 |
Llorens F et al. | Unbalanced activation of ERK1/2 and MEK1/2 in apigenin-induced HeLa cell death. | 2004 | Exp. Cell Res. | pmid:15302569 |
Sosa T et al. | Inhibition of mouth skeletal muscle relaxation by flavonoids of Cistus ladanifer L.: a plant defense mechanism against herbivores. | 2004 | J. Chem. Ecol. | pmid:15303316 |
Psotová J et al. | Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin. | 2004 | Phytother Res | pmid:15305308 |
Cotter AA and Cashman KD | The effect of two dietary and a synthetic phytoestrogen on transepithelial calcium transport in human intestinal-like Caco-2 cells. | 2005 | Eur J Nutr | pmid:15309423 |
Pereira CA et al. | A HPTLC densitometric determination of flavonoids from Passiflora alata, P. edulis, P. incarnata and P. caerulea and comparison with HPLC method. | 2004 Jul-Aug | Phytochem Anal | pmid:15311844 |
Kaiser CS et al. | Supercritical carbon dioxide extraction of chamomile flowers: extraction efficiency, stability, and in-line inclusion of chamomile-carbon dioxide extract in beta-cyclodextrin. | 2004 Jul-Aug | Phytochem Anal | pmid:15311845 |
Cai H et al. | Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo. | 2004 | Br. J. Cancer | pmid:15316567 |
Sanderson JT et al. | Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. | 2004 | Toxicol. Sci. | pmid:15319488 |
Chen CC et al. | Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. | 2004 | Mol. Pharmacol. | pmid:15322261 |
Flamini R and Dalla Vedova A | Fast determination of the total free resveratrol content in wine by direct-exposure-probe, positive-ion chemical ionization and collision-induced-dissociation mass spectrometry. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15329858 |
Kim KY et al. | Anti-apoptotic action of (2S,3S,4R)-N"-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378) by suppression of the phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and increased phosphorylation of casein kinase2/Akt/ cyclic AMP response element binding protein via maxi-K channel opening in neuronal cells. | 2004 | Eur. J. Pharmacol. | pmid:15336944 |
Mizoyama Y et al. | Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes. | 2004 | Biol. Pharm. Bull. | pmid:15340238 |
Loizzo MR et al. | Antimicrobial activity and cytotoxicity of Cirsium tenoreanum. | 2004 | Fitoterapia | pmid:15351112 |
Droillard MJ et al. | Involvement of MPK4 in osmotic stress response pathways in cell suspensions and plantlets of Arabidopsis thaliana: activation by hypoosmolarity and negative role in hyperosmolarity tolerance. | 2004 | FEBS Lett. | pmid:15358537 |
pmid:15360311 | ||||
Matsufuji H and Shibamoto T | Inhibition of malonaldehyde formation in oxidized calf thymus DNA with synthetic and natural antioxidants. | 2004 | J. Agric. Food Chem. | pmid:15373421 |
Calderone V et al. | Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. | 2004 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:15378228 |
Svehliková V et al. | Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert). | 2004 | Phytochemistry | pmid:15381003 |
Osada M et al. | Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein. | 2004 | FEBS Lett. | pmid:15388333 |
Campbell EL et al. | The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. | 2004 | Biochem. Pharmacol. | pmid:15451406 |
Maciel ME et al. | Inhibition of the rat breast cytosolic bioactivation of ethanol to acetaldehyde by some plant polyphenols and folic acid. | 2004 | Nutr Cancer | pmid:15456641 |
Losi G et al. | Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons. | 2004 | Eur. J. Pharmacol. | pmid:15464088 |
Gradolatto A et al. | Pharmacokinetics and metabolism of apigenin in female and male rats after a single oral administration. | 2005 | Drug Metab. Dispos. | pmid:15466493 |
Ko WC et al. | Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. | 2004 | Biochem. Pharmacol. | pmid:15476679 |
Sarkar FH and Li Y | Cell signaling pathways altered by natural chemopreventive agents. | 2004 | Mutat. Res. | pmid:15476851 |
Siciliano T et al. | Study of flavonoids of Sechium edule (Jacq) Swartz (Cucurbitaceae) different edible organs by liquid chromatography photodiode array mass spectrometry. | 2004 | J. Agric. Food Chem. | pmid:15479015 |
Mazol I et al. | Polyphenolic compounds from Platycodon grandiflorum A. DC. | 2004 May-Jun | Acta Pol Pharm | pmid:15481246 |
Morrissey C et al. | Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells. | 2005 | Prostate | pmid:15486995 |
Shenouda NS et al. | Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. | 2004 | Nutr Cancer | pmid:15489213 |
Yang L et al. | [Studies on chemical constituents in rhizome of Matteuccia struthiopteris]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15503769 |
Oh H et al. | Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense. | 2004 | J Ethnopharmacol | pmid:15507369 |
Czyz J et al. | Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro. | 2005 | Int. J. Cancer | pmid:15523693 |
Brusselmans K et al. | Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. | 2005 | J. Biol. Chem. | pmid:15533929 |
Ponce MA et al. | Flavonoids from shoots, roots and roots exudates of Brassica alba. | 2004 | Phytochemistry | pmid:15541742 |
Murkovic M et al. | Analysis of minor components in olive oil. | 2004 | J. Biochem. Biophys. Methods | pmid:15560931 |
Woodman OL and Chan ECh | Vascular and anti-oxidant actions of flavonols and flavones. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15566394 |
Monasterio A et al. | Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways. | 2004 | Nutr Cancer | pmid:15572302 |
Yi J et al. | Phytoecdysteroids and glycoceramides from Eriophyton wallchii. | 2004 | Steroids | pmid:15582536 |
Takagaki N et al. | Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway. | 2005 | Int. J. Oncol. | pmid:15586239 |
Franek KJ et al. | In vitro studies of baicalin alone or in combination with Salvia miltiorrhiza extract as a potential anti-cancer agent. | 2005 | Int. J. Oncol. | pmid:15586243 |
Uma Devi P and Satyamitra M | Protection against prenatal irradiation-induced genomic instability and its consequences in adult mice by Ocimum flavonoids, orientin and vicenin. | 2004 | Int. J. Radiat. Biol. | pmid:15586885 |
Lamien CE et al. | Inhibition of fowlpox virus by an aqueous acetone extract from galls of Guiera senegalensis J. F. Gmel (Combretaceae). | 2005 | J Ethnopharmacol | pmid:15588677 |
Anzellotti D and Ibrahim RK | Molecular characterization and functional expression of flavonol 6-hydroxylase. | 2004 | BMC Plant Biol. | pmid:15596008 |
Wong CH et al. | Blood-testis barrier dynamics are regulated by {alpha}2-macroglobulin via the c-Jun N-terminal protein kinase pathway. | 2005 | Endocrinology | pmid:15618353 |
Doyama JT et al. | Chemical investigation and effects of the tea of Passiflora alata on biochemical parameters in rats. | 2005 | J Ethnopharmacol | pmid:15619554 |
Way TD et al. | Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells. | 2005 | FEBS Lett. | pmid:15620704 |
Hougee S et al. | Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages. | 2005 | Biochem. Pharmacol. | pmid:15627476 |
Wang WS et al. | [Studies on the flavonoids in herb from Scutellaria barbata]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15631081 |
Khan SB et al. | Tyrosinase-inhibitory long-chain esters from Amberboa ramosa. | 2005 | Chem. Pharm. Bull. | pmid:15635236 |
Horváthová K et al. | Determination of free radical scavenging activity of quercetin, rutin, luteolin and apigenin in H2O2-treated human ML cells K562. | 2004 | Neoplasma | pmid:15640946 |
Sadeghipour M et al. | Flavonoids and tyrosine nitration: structure-activity relationship correlation with enthalpy of formation. | 2005 | Toxicol In Vitro | pmid:15649628 |
Liu Z et al. | [Determination of orientin and vitexin in Trollius chinesis preparation by HPLC]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15656135 |
Torkin R et al. | Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. | 2005 | Mol. Cancer Ther. | pmid:15657348 |
Nayak V and Devi PU | Protection of mouse bone marrow against radiation-induced chromosome damage and stem cell death by the ocimum flavonoids orientin and vicenin. | 2005 | Radiat. Res. | pmid:15658892 |
Liu H et al. | Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide. | 2005 | Pharmacol. Res. | pmid:15661569 |
Guerrero JA et al. | Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. | 2005 | J. Thromb. Haemost. | pmid:15670046 |
van Zanden JJ et al. | Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2. | 2005 | Biochem. Pharmacol. | pmid:15670588 |
Zheng PW et al. | Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells. | 2005 | Life Sci. | pmid:15670616 |
Elsisi NS et al. | Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia. | 2005 | Neurosci. Lett. | pmid:15670648 |
Agrell J et al. | Combined effects of elevated CO2 and herbivore damage on alfalfa and cotton. | 2004 | J. Chem. Ecol. | pmid:15672673 |
Zhang J et al. | Characterization of flavonoids by aluminum complexation and collisionally activated dissociation. | 2005 | J Mass Spectrom | pmid:15674859 |
Matsuo M et al. | Cytotoxicity of flavonoids toward cultured normal human cells. | 2005 | Biol. Pharm. Bull. | pmid:15684479 |
Izeradjene K et al. | Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines. | 2005 | Oncogene | pmid:15688023 |
Deepak M et al. | Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC. | Phytochem Anal | pmid:15688952 | |
Suntornsuk L and Anurukvorakun O | Precision improvement for the analysis of flavonoids in selected Thai plants by capillary zone electrophoresis. | 2005 | Electrophoresis | pmid:15690438 |
Weldon CB et al. | PKC-mediated survival signaling in breast carcinoma cells: a role for MEK1-AP1 signaling. | 2005 | Int. J. Oncol. | pmid:15703835 |
Gu HF et al. | [Studies on chemical constituents from herb of Dracocephalum moldavica]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706847 |
Su J et al. | [Determination of flavoniod-glycosides in Yixintong pills by HPLC]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706914 |