apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Premature Birth D047928 6 associated lipids
Lymphoma, Primary Effusion D054685 2 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Authors Title Published Journal PubMed Link
Ashokkumar R et al. Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. 2018 Biochem. Biophys. Res. Commun. pmid:29406244
Liu X et al. Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches. 2018 Nat Commun pmid:29386648
Lv SX and Qiao X Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. 2018 Biochem. Biophys. Res. Commun. pmid:29355527
Radulovic K et al. A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation. 2018 Mucosal Immunol pmid:29139477
Nabavi SF et al. Apigenin as neuroprotective agent: Of mice and men. 2018 Pharmacol. Res. pmid:29055745
Zhao Q et al. Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis. 2018 Mol Plant pmid:28842248
Abu Bakar AR et al. Experimental and computational approaches to reveal the potential of Ficus deltoidea leaves extract as α-amylase inhibitor. 2018 Nat. Prod. Res. pmid:28391727
Ravisankar S et al. Structural profile of soluble and bound phenolic compounds in teff (Eragrostis tef) reveals abundance of distinctly different flavones in white and brown varieties. 2018 Food Chem pmid:29784316
Alzoman NZ et al. CE-DAD Determination of Scutellarein and Caffeic Acid in Abelia triflora Crude Extract. 2018 J Chromatogr Sci pmid:29750262
Jiang J et al. Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR/Ulk1 pathway. 2018 Biomed. Pharmacother. pmid:29710456
Gaspar MC et al. Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract. 2018 Nat. Prod. Res. pmid:28627294
Feng X et al. Characterization of the In Vivo and In Vitro Metabolites of Linarin in Rat Biosamples and Intestinal Flora Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. 2018 Molecules pmid:30149616
Makanjuola SBL et al. Apigenin and apigeninidin isolates from the Sorghum bicolor leaf targets inflammation via cyclo-oxygenase-2 and prostaglandin-E blockade. 2018 Int J Rheum Dis pmid:30146750
Chang JH et al. Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses. 2018 J. Exp. Clin. Cancer Res. pmid:30134935
Kowalczyk A et al. Insights into novel anticancer applications for apigenin. 2017 Adv Clin Exp Med pmid:29211364
You L et al. Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. 2017 Bioorg. Med. Chem. Lett. pmid:29157862
He X et al. Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat. 2017 Am. J. Chin. Med. pmid:29121796
Wu W et al. Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique. 2017 Drug Deliv pmid:29115900
Tu F et al. Angiogenic effects of apigenin on endothelial cells after hypoxia-reoxygenation via the caveolin-1 pathway. 2017 Int. J. Mol. Med. pmid:29039442
Dang Y et al. Protective effects of apigenin against acrylonitrile-induced subchronic sperm injury in rats. 2017 Food Chem. Toxicol. pmid:28963002
Mehmood K et al. In Vitro Effect of Apigenin and Danshen in Tibial Dyschondroplasia Through Inhibition of Heat-Shock Protein 90 and Vascular Endothelial Growth Factor Expressions in Avian Growth Plate Cells. 2017 Avian Dis. pmid:28957003
Agah S et al. Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS-induced inflammation in colonic myofibroblasts. 2017 Mol Nutr Food Res pmid:28155259
Viacava GE et al. Characterization of phenolic compounds in green and red oak-leaf lettuce cultivars by UHPLC-DAD-ESI-QToF/MS using MS scan mode. 2017 J Mass Spectrom pmid:28833875
Li F et al. Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy. 2017 Oxid Med Cell Longev pmid:28828145
Tan GF et al. AgFNS overexpression increase apigenin and decrease anthocyanins in petioles of transgenic celery. 2017 Plant Sci. pmid:28818381
Wang M et al. Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus. 2017 Molecules pmid:28771188
Jin X et al. Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. 2017 Int J Nanomedicine pmid:28761344
Gu T et al. Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative. 2017 Molecules pmid:28635646
Nurdiana S et al. Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. 2017 BMC Complement Altern Med pmid:28576138
Bauer D et al. Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. 2017 PLoS ONE pmid:28441391
Meng S et al. Apigenin inhibits renal cell carcinoma cell proliferation. 2017 Oncotarget pmid:28423637
Mahajan UB et al. The Protective Effect of Apigenin on Myocardial Injury in Diabetic Rats mediating Activation of the PPAR-γ Pathway. 2017 Int J Mol Sci pmid:28375162
Zhong Y et al. Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. 2017 Toxicon pmid:28734981
Wang J et al. Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy. 2017 J Nanobiotechnology pmid:28249594
Souza RP et al. Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines. 2017 Oxid Med Cell Longev pmid:28191273
Hicks DF et al. Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. 2017 Sci Rep pmid:28256512
Nelson N et al. Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer. 2017 PLoS ONE pmid:28152014
Wang F et al. Vitexin alleviates lipopolysaccharide‑induced islet cell injury by inhibiting HMGB1 release. 2017 Mol Med Rep pmid:28098903
Yang LL et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. 2017 Biochim Biophys Acta Mol Basis Dis pmid:27903431
Stump TA et al. The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. 2017 J. Pharm. Pharmacol. pmid:28349530
Sun XP et al. Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. 2017 Arch. Pharm. Res. pmid:28315259
Ferrazzi P et al. Pollination effects on antioxidant content of Perilla frutescens seeds analysed by NMR spectroscopy. 2017 Nat. Prod. Res. pmid:28278651
Verma S et al. Natural polyphenolic inhibitors against the antiapoptotic BCL-2. 2017 J. Recept. Signal Transduct. Res. pmid:28264627
Kalivarathan J et al. Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet. 2017 Biomed. Pharmacother. pmid:28237914
Wang N et al. Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense. 2017 In Vitro Cell. Dev. Biol. Anim. pmid:28181104
Telange DR et al. Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential. 2017 Eur J Pharm Sci pmid:27939619
Yao H et al. DPPH·-luminol chemiluminescence system and its application in the determination of scutellarin in pharmaceutical injections and rat plasma with flow injection analysis. 2017 Luminescence pmid:27860193
Zhang L et al. Comparative study of the binding of 3 flavonoids to the fat mass and obesity-associated protein by spectroscopy and molecular modeling. 2017 J. Mol. Recognit. pmid:28058739
Bhatt V et al. Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF-MS/MS. 2017 J Pharm Biomed Anal pmid:27693952
Granato M et al. Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. 2017 J. Exp. Clin. Cancer Res. pmid:29179721
Fan H et al. Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. 2017 Med. Sci. Monit. pmid:29172017
Gu C et al. Preparation of Vitexin Nanoparticles by Combining the Antisolvent Precipitation and High Pressure Homogenization Approaches Followed by Lyophilization for Dissolution Rate Enhancement. 2017 Molecules pmid:29165376
Jeong KM et al. Identification of Major Flavone C-Glycosides and Their Optimized Extraction from Cymbidium kanran Using Deep Eutectic Solvents. 2017 Molecules pmid:29156555
Wu T et al. Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). 2017 Pharmacol Rep pmid:29128807
Hou L et al. Scutellarin Inhibits Proliferation, Invasion, and Tumorigenicity in Human Breast Cancer Cells by Regulating HIPPO-YAP Signaling Pathway. 2017 Med. Sci. Monit. pmid:29079722
Kulikovskii VF et al. Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect. 2017 Bull. Exp. Biol. Med. pmid:29063320
Mokashi P et al. Swertisin rich fraction from Enicostema littorale ameliorates hyperglycemia and hyperlipidemia in high-fat fed diet and low dose streptozotacin induced type 2 diabetes mellitus in rats. 2017 Biomed. Pharmacother. pmid:29031588
Britto SM et al. Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. 2017 Mutat. Res. pmid:28735741
Jangdey MS et al. Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. 2017 Drug Deliv pmid:28687053
Choi WH et al. Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. 2017 Mol Nutr Food Res pmid:28971573
Perez-Leal O et al. Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. 2017 J. Biol. Chem. pmid:28684421
Zhao T et al. Novel apigenin-loaded sodium hyaluronate nano-assemblies for targeting tumor cells. 2017 Carbohydr Polym pmid:28962787
Hassoun SM et al. Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. 2017 Tumour Biol. pmid:28651490
Sang Y et al. Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. 2017 Food Funct pmid:28598487
Malik S et al. Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. 2017 Am. J. Physiol. Renal Physiol. pmid:28566504
Yao HM et al. [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. 2017 Zhonghua Xin Xue Guan Bing Za Zhi pmid:28545285
Fernandes LM et al. Genotoxicity and Antigenotoxicity Assessments of the Flavonoid Vitexin by the Drosophila melanogaster Somatic Mutation and Recombination Test. 2017 J Med Food pmid:28541831
Ninfali P et al. C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review. 2017 Phytother Res pmid:28464411
Han T et al. Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation. 2017 Eur J Med Chem pmid:28458133
Adaszyńska-Skwirzyńska M and Dzięcioł M Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. 2017 Nat. Prod. Res. pmid:28449600
Mohammad F E et al. Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. 2017 J. Biochem. Mol. Toxicol. pmid:28422384
Feng X et al. Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. 2017 Biochem. Pharmacol. pmid:28414138
Karim R et al. Development and evaluation of injectable nanosized drug delivery systems for apigenin. 2017 Int J Pharm pmid:28456651
Soyman Z et al. Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. 2017 Balkan Med J pmid:28443590
Chen F et al. An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. 2017 Ultrason Sonochem pmid:28427633
Lin CM et al. Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. 2017 Sci Rep pmid:28337019
Pápay ZE et al. Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity. 2017 J Aerosol Med Pulm Drug Deliv pmid:28282259
Rašković A et al. Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model. 2017 Eur J Drug Metab Pharmacokinet pmid:28255865
Jangdey MS et al. Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation. 2017 Artif Cells Nanomed Biotechnol pmid:28050929
Erdogan S et al. The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. 2017 Biomed. Pharmacother. pmid:28107698
Thirusangu P et al. Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. 2017 Biochem. Biophys. Res. Commun. pmid:28104392
Yang N et al. Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. 2017 Mol Med Rep pmid:28035355
Banerjee K et al. Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions. 2017 J Colloid Interface Sci pmid:28012918
Ke Y et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. 2017 Biochem. Biophys. Res. Commun. pmid:27998773
Li Y et al. Pharmacokinetic Study of Swertisin by HPLC-MS/MS After Intravenous Administration in Rats. 2017 J Chromatogr Sci pmid:27993862
Wang B and Zhao XH Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells. 2017 Oncol. Rep. pmid:27959417
Bai Y et al. Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications. 2017 Appl. Biochem. Biotechnol. pmid:27933483
Sheeja Malar D et al. Cholinesterase inhibitory, anti-amyloidogenic and neuroprotective effect of the medicinal plant Grewia tiliaefolia - An in vitro and in silico study. 2017 Pharm Biol pmid:27931177
Lecomte S et al. Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. 2017 Toxicol. Appl. Pharmacol. pmid:28396216
Tan YQ et al. Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. 2017 Mol. Cell. Biochem. pmid:27778136
Oh HK et al. Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice. 2017 J. Psychopharmacol. (Oxford) pmid:27729563
Guzelmeric E et al. Quality assessment of marketed chamomile tea products by a validated HPTLC method combined with multivariate analysis. 2017 J Pharm Biomed Anal pmid:27693951
Oliveira KG et al. Effect of the storage time and temperature on phenolic compounds of sorghum grain and flour. 2017 Food Chem pmid:27596435
Pápay ZE et al. Controlled Release Oral Delivery of Apigenin Containing Pellets with Antioxidant Activity. 2017 Curr Drug Deliv pmid:27264725
Gutiérrez-Venegas G and González-Rosas Z Apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells. 2017 Arch. Pharm. Res. pmid:27193174
Das A et al. Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. 2017 J. Photochem. Photobiol. B, Biol. pmid:28456117
Wang J et al. Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. 2017 Int J Nanomedicine pmid:29158673
Hassan SM et al. Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. 2017 Pharm Biol pmid:28064632
Golea L et al. Phytochemical components and biological activities of Silene arenarioides Desf. 2017 Nat. Prod. Res. pmid:28278644
Gómez-Zorita S et al. Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes. 2017 J Transl Med pmid:29162103