apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Premature Birth D047928 6 associated lipids
Lymphoma, Primary Effusion D054685 2 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

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What genes are associated with apigenin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Authors Title Published Journal PubMed Link
He JD et al. Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway. 2016 Oncotarget pmid:27588401
Qin Y et al. Apigenin inhibits NF-κB and snail signaling, EMT and metastasis in human hepatocellular carcinoma. 2016 Oncotarget pmid:27203387
Xie Y et al. Preparative Separation and Purification of the Total Flavonoids in Scorzonera austriaca with Macroporous Resins. 2016 Molecules pmid:27304948
Peng HY et al. Apigenin-7-O-β-D-glycoside isolation from the highly copper-tolerant plant Elsholtzia splendens. 2016 J Zhejiang Univ Sci B pmid:27256678
Jung UJ et al. Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice. 2016 Nutrients pmid:27213439
Yagishita Y et al. Photochromic Properties of 3-Deoxyanthocyanidin Pigments in Nontoxic Solvents. 2016 J. Food Sci. pmid:27925261
Xiao L et al. A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP. 2016 Eur J Pharm Sci pmid:27586020
Zeng L et al. Inhibitory Mechanism of Apigenin on α-Glucosidase and Synergy Analysis of Flavonoids. 2016 J. Agric. Food Chem. pmid:27581205
Erdogan S et al. The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling. 2016 Life Sci. pmid:27569589
Wang X et al. Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer. 2016 Fitoterapia pmid:27102611
Dubois N et al. Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential. 2016 Int. J. Oncol. pmid:27098015
Simeonova R et al. Antidiabetic and antioxidant effects of saponarin from Gypsophila trichotoma on streptozotocin-induced diabetic normotensive and hypertensive rats. 2016 Phytomedicine pmid:27064007
Romero GB et al. Simple low-cost miniaturization approach for pharmaceutical nanocrystals production. 2016 Int J Pharm pmid:26642945
Cochran DB et al. Degradable poly(apigenin) polymer inhibits tumor cell adhesion to vascular endothelial cells. 2016 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:26251070
Iqbal MK et al. Recovery of Chicken Growth Plate by Heat-Shock Protein 90 Inhibitors Epigallocatechin-3-Gallate and Apigenin in Thiram-Induced Tibial Dyschondroplasia. 2016 Avian Dis. pmid:27902918
Lee W and Bae JS Antithrombotic and antiplatelet activities of vicenin-2. 2015 Blood Coagul. Fibrinolysis pmid:26126169
Andueza A et al. Oxidation pathways underlying the pro-oxidant effects of apigenin. 2015 Free Radic. Biol. Med. pmid:26119779
Granica S et al. The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid sources of Agrimoniae herba--The pharmacopoeial plant material. 2015 J Pharm Biomed Anal pmid:26092224
Lee W et al. Ameliorative Effect of Vicenin-2 and Scolymoside on TGFBIp-Induced Septic Responses. 2015 Inflammation pmid:26084452
de Santana Aquino DF et al. Anti-hyperalgesic and Anti-inflammatory Activity of Alternanthera Maritima Extract and 2″-O-α-L-rhamnopyranosylvitexin in Mice. 2015 Inflammation pmid:26045342
Yin Q et al. In vitro-assessment of putative antiprogestin activities of phytochemicals and synthetic UV absorbers in human endometrial Ishikawa cells. 2015 Gynecol. Endocrinol. pmid:26036805
Liu X et al. Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway. 2015 Oncol. Rep. pmid:26035210
Li Y et al. Pharmacokinetics and tissue distribution study of Isovitexin in rats by HPLC-MS/MS. 2015 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:25902051
Wang Q et al. Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis. 2015 Int. Immunopharmacol. pmid:25899084
Shi T et al. [Effect of apigenin on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis]. 2015 Zhonghua Gan Zang Bing Za Zhi pmid:25880979
Xu C et al. Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines. 2015 Xenobiotica pmid:25869249
Wei L et al. Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions. 2015 J Sep Sci pmid:25866087
Zhang G et al. Effects of germination on the nutritional properties, phenolic profiles, and antioxidant activities of buckwheat. 2015 J. Food Sci. pmid:25858540
Wang Y et al. Vitexin protects brain against ischemia/reperfusion injury via modulating mitogen-activated protein kinase and apoptosis signaling in mice. 2015 Phytomedicine pmid:25837275
Sang Z et al. Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. 2015 Eur J Med Chem pmid:25778991
Fonseca-Silva F et al. Effect of Apigenin on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction. 2015 J. Nat. Prod. pmid:25768915
Ju WZ et al. Clinical tolerability and pharmacokinetics of Erigerontis hydroxybenzene injection: results of a randomized phase I study in healthy Chinese volunteers. 2015 Phytomedicine pmid:25765839
Nabavi SM et al. Apigenin and Breast Cancers: From Chemistry to Medicine. 2015 Anticancer Agents Med Chem pmid:25738871
Niu C et al. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. 2015 J Ethnopharmacol pmid:25701748
Patil RH et al. Apigenin inhibits PMA-induced expression of pro-inflammatory cytokines and AP-1 factors in A549 cells. 2015 Mol. Cell. Biochem. pmid:25666088
Mustapha N et al. Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis. 2015 Biomed. Pharmacother. pmid:25661350
Mascaraque C et al. Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium. 2015 Br. J. Nutr. pmid:25654996
Barlas N and Karabulut G Haematological and histopathological effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar female albino rats. 2015 Hum Exp Toxicol pmid:25378093
Costa G et al. Flavan hetero-dimers in the Cymbopogon citratus infusion tannin fraction and their contribution to the antioxidant activity. 2015 Food Funct pmid:25652784
Arango D et al. Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. 2015 Mol Nutr Food Res pmid:25641956
Zhang S et al. Studies on the interaction of apigenin with calf thymus DNA by spectroscopic methods. 2015 Spectrochim Acta A Mol Biomol Spectrosc pmid:25459730
Djouossi MG et al. Antimicrobial and antioxidant flavonoids from the leaves of Oncoba spinosa Forssk. (Salicaceae). 2015 BMC Complement Altern Med pmid:25928352
Heredia-Vieira SC et al. Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves. 2015 J. Nat. Prod. pmid:25517504
Germanò MP et al. Anti-angiogenic activity of Entada africana root. 2015 Nat. Prod. Res. pmid:25482106
Saeed M et al. Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking. 2015 J. Nutr. Biochem. pmid:25459885
Scholz P and Keck CM Flavonoid nanocrystals produced by ARTcrystal®-technology. 2015 Int J Pharm pmid:25448550
Wang XS et al. Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats. 2015 Phytother Res pmid:25447838
Singh V et al. Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells. 2015 Eur J Nutr pmid:25408199
Tang AQ et al. Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3‑derived sphere-forming cells. 2015 Mol Med Rep pmid:25405327
Li LH et al. Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells. 2015 Int J Clin Exp Pathol pmid:26722444
Hu J et al. Protective effect of apigenin on ischemia/reperfusion injury of the isolated rat heart. 2015 Cardiovasc. Toxicol. pmid:25377428
Pereira C et al. Infusions of artichoke and milk thistle represent a good source of phenolic acids and flavonoids. 2015 Food Funct pmid:25367590
Lin CH et al. Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. 2015 BMC Cancer pmid:26675309
Hu XY et al. 5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma. 2015 Clin. Exp. Pharmacol. Physiol. pmid:25363523
Hasnat MA et al. Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition. 2015 Molecules pmid:26633318
Zhu Y et al. Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer. 2015 Mol Med Rep pmid:25351792
Liu J et al. Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2α. 2015 Mol Med Rep pmid:25334018
Shibamoto T A novel gas chromatographic method for determination of malondialdehyde from oxidized DNA. 2015 Methods Mol. Biol. pmid:25323498
Wu PS et al. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. 2015 PLoS ONE pmid:26087007
Farkas O et al. Polymethoxyflavone Apigenin-Trimethylether Suppresses LPS-Induced Inflammatory Response in Nontransformed Porcine Intestinal Cell Line IPEC-J2. 2015 Oxid Med Cell Longev pmid:26180592
Fang J et al. Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1. 2015 Mol Med Rep pmid:26300442
Falcone Ferreyra ML et al. The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions. 2015 Plant Physiol. pmid:26269546
Cattaneo L et al. Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells. 2015 PLoS ONE pmid:26176704
Jeon BJ et al. Apigenin inhibits indoxyl sulfate-induced endoplasmic reticulum stress and anti-proliferative pathways, CHOP and IL-6/p21, in human renal proximal tubular cells. 2015 Eur Rev Med Pharmacol Sci pmid:26166660
Zhang Y et al. Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway. 2015 Eur J Histochem pmid:26150153
Tang H et al. Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult. 2015 PLoS ONE pmid:26147971
Ma X et al. Acylation of Antioxidant of Bamboo Leaves with Fatty Acids by Lipase and the Acylated Derivatives' Efficiency in the Inhibition of Acrylamide Formation in Fried Potato Crisps. 2015 PLoS ONE pmid:26098744
Gao R et al. Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. 2015 Biomed. Chromatogr. pmid:25042239
Shiota C et al. Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes. 2015 J. Nutr. Sci. Vitaminol. pmid:26052151
Dadheech N et al. Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study. 2015 PLoS ONE pmid:26047129
Zhang W et al. A new and efficient synthesis of 6-O-methylscutellarein, the major metabolite of the natural medicine scutellarin. 2015 Molecules pmid:26042857
Lee H et al. Biosynthesis of Two Flavones, Apigenin and Genkwanin, in Escherichia coli. 2015 J. Microbiol. Biotechnol. pmid:25975614
Banerjee K and Mandal M Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells. 2015 Redox Biol pmid:25965143
Zeng P et al. Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen Activator Inhibitor-2. 2015 Oxid Med Cell Longev pmid:25960827
del Cerro P et al. Regulatory nodD1 and nodD2 genes of Rhizobium tropici strain CIAT 899 and their roles in the early stages of molecular signaling and host-legume nodulation. 2015 BMC Genomics pmid:25880529
Long L et al. Protective effects of scutellarin on type II diabetes mellitus-induced testicular damages related to reactive oxygen species/Bcl-2/Bax and reactive oxygen species/microcirculation/staving pathway in diabetic rat. 2015 J Diabetes Res pmid:25861655
Kumar KK et al. Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats. 2015 Eur J Drug Metab Pharmacokinet pmid:24871039
Shi X et al. Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo. 2015 Int. J. Mol. Med. pmid:25394920
Gulluce M et al. Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genotoxic potency. 2015 Toxicol Ind Health pmid:23377117
Chomicki G et al. The velamen protects photosynthetic orchid roots against UV-B damage, and a large dated phylogeny implies multiple gains and losses of this function during the Cenozoic. 2015 New Phytol. pmid:25345817
Avelino-Flores Mdel C et al. Cytotoxic activity of the methanolic extract of Turnera diffusa Willd on breast cancer cells. 2015 J Med Food pmid:25299247
Wright B et al. GRID and docking analyses reveal a molecular basis for flavonoid inhibition of Src family kinase activity. 2015 J. Nutr. Biochem. pmid:26140983
Aslan E and Adem S In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. 2015 J. Biochem. Mol. Toxicol. pmid:25388478
Yamagata K et al. Dietary polyphenols regulate endothelial function and prevent cardiovascular disease. 2015 Nutrition pmid:25466651
Chen RB et al. Deep Sequencing Reveals the Effect of MeJA on Scutellarin Biosynthesis in Erigeron breviscapus. 2015 PLoS ONE pmid:26656917
Sun H et al. Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling. 2015 J. Agric. Food Chem. pmid:26066637
Li H et al. Separation of vitexin-4″-O-glucoside and vitexin-2″-O-rhamnoside from hawthorn leaves extracts using macroporous resins. 2015 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:26562804
Zemanova L et al. Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment. 2015 J. Nat. Prod. pmid:26529431
Shi ZH et al. Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. 2015 Eur J Med Chem pmid:26523667
Kang H et al. Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo. 2015 Inflamm. Res. pmid:26482935
Bhardwaj M et al. Potential role of vitexin in alleviating heat stress-induced cytotoxicity: Regulatory effect of Hsp90 on ER stress-mediated autophagy. 2015 Life Sci. pmid:26475763
Seo WD et al. Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5. 2015 Bioorg. Med. Chem. Lett. pmid:26471090
Lin CH et al. Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-κB pathways in human lung epithelial cells. 2015 Eur. J. Pharmacol. pmid:26463037
Shi ZH et al. Synthesis of scutellarein derivatives to increase biological activity and water solubility. 2015 Bioorg. Med. Chem. pmid:26455656
Zhang X et al. Stable knock-down of efflux transporters leads to reduced glucuronidation in UGT1A1-overexpressing HeLa cells: the evidence for glucuronidation-transport interplay. 2015 Mol. Pharm. pmid:25741749
Bao YY et al. Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo. 2015 Oncol. Rep. pmid:26238658
Long HP et al. Involvenflavones A-F, six new flavonoids with 3'-aryl substituent from Selaginella involven. 2015 Fitoterapia pmid:26226107
Zhan YY et al. Inhibitory Effect of Apigenin on Pharmacokinetics of Venlafaxine in vivo and in vitro. 2015 Pharmacology pmid:26202346
Min JW et al. Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. 2015 Neuropharmacology pmid:26187393
Hong H et al. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. 2015 Toxicol. Sci. pmid:25349334