| MeSH term | MeSH ID | Detail |
|---|---|---|
| Premature Birth | D047928 | 6 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang S et al. | Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. | 2003 | Environ. Health Perspect. | pmid:14644660 |
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| Xie C et al. | Flavone C-glycosides from Viola yedoensis MAKINO. | 2003 | Chem. Pharm. Bull. | pmid:14519932 |
| Wang H et al. | Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12975498 |
| Oku H et al. | Antipruritic effects of the fruits of Chaenomeles sinensis. | 2003 | Biol. Pharm. Bull. | pmid:12843634 |
| Yee SB et al. | Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells. | 2003 | Arch. Pharm. Res. | pmid:12643593 |
| Sikorska M et al. | Application of mass spectrometric techniques for structural analysis of apigenin 8-C-(6"-O-glucopyranosyl) glucopyranoside--a novel flavonoid C-diglycoside. | 2003 | Rapid Commun. Mass Spectrom. | pmid:12811762 |
| Miller CP et al. | Constrained phytoestrogens and analogues as ERbeta selective ligands. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12824043 |
| Leslie EM et al. | Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). | 2003 | Drug Metab. Dispos. | pmid:12485947 |
| Morimoto M et al. | Insect antifeedant activity of flavones and chromones against Spodoptera litura. | 2003 | J. Agric. Food Chem. | pmid:12517100 |
| Springsteel MF et al. | Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. | 2003 | Bioorg. Med. Chem. | pmid:12927873 |
| Beyer G and Melzig MF | Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells. | 2003 | Planta Med. | pmid:14750029 |
| Hu M et al. | Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12893842 |
| Smolinski AT and Pestka JJ | Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew). | 2003 | Food Chem. Toxicol. | pmid:12909272 |
| Dias C et al. | Structural elucidation of natural 2-hydroxy di- and tricarboxylic acids and esters, phenylpropanoid esters and a flavonoid from Autonoë madeirensis using gas chromatographic/electron ionization, electrospray ionization and tandem mass spectrometric techniques. | 2003 | J Mass Spectrom | pmid:14696202 |
| Chan TS et al. | Simultaneous detection of the antioxidant and pro-oxidant activity of dietary polyphenolics in a peroxidase system. | 2003 | Free Radic. Res. | pmid:12911276 |
| Simirgiotis MJ et al. | New dammarane triterpenes from the aerial parts of Ibicella lutea grown in Argentina. | 2003 | J. Nat. Prod. | pmid:14695802 |
| Farah M et al. | 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12842827 |
| Hou CC et al. | Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica. | 2003 | J. Nat. Prod. | pmid:12762795 |
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| Owen RW et al. | Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes. | 2003 | Food Chem. Toxicol. | pmid:12659724 |
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| Kavvadias D et al. | Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. | 2003 | Planta Med. | pmid:12624814 |
| Basile A et al. | Effects of seven pure flavonoids from mosses on germination and growth of Tortula muralis HEDW (Bryophyta) and Raphanus sativus L (Magnoliophyta). | 2003 | Phytochemistry | pmid:12591270 |
| McPhail DB et al. | Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. | 2003 | J. Agric. Food Chem. | pmid:12617605 |
| Kuwabara H et al. | Tricin from a malagasy connaraceous plant with potent antihistaminic activity. | 2003 | J. Nat. Prod. | pmid:14510616 |
| Whitehead SA and Lacey M | Phytoestrogens inhibit aromatase but not 17beta-hydroxysteroid dehydrogenase (HSD) type 1 in human granulosa-luteal cells: evidence for FSH induction of 17beta-HSD. | 2003 | Hum. Reprod. | pmid:12615812 |
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| Koo H et al. | Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. | 2003 | J. Antimicrob. Chemother. | pmid:14563892 |
| Naderi GA et al. | Anti-oxidant effect of flavonoids on the susceptibility of LDL oxidation. | 2003 | Mol. Cell. Biochem. | pmid:12841362 |
| Jarry H et al. | Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones. | 2003 | Planta Med. | pmid:14648399 |
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| Zhong D et al. | Determination of scutellarin in rat plasma by high-performance liquid chromatography with ultraviolet detection. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14581083 |
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| Peterson J et al. | Flavonoid intake and breast cancer risk: a case--control study in Greece. | 2003 | Br. J. Cancer | pmid:14520456 |
| Liu YM et al. | Study on pharmacokinetics of scutellarin in rabbits. | 2003 | Yao Xue Xue Bao | pmid:14730903 |
| Zhang JL et al. | Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR. | 2003 | J Asian Nat Prod Res | pmid:14604233 |
| Van Dross R et al. | The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines. | 2003 | J. Nutr. | pmid:14608117 |
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| Cushnie TP et al. | Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports. | 2003 | Microbiol. Res. | pmid:14717448 |
| Amakura Y et al. | Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. | 2003 | Biol. Pharm. Bull. | pmid:14646185 |
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| Kim MH | Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases. | 2003 | J. Cell. Biochem. | pmid:12761886 |
| Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
| Xie LP et al. | Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase. | 2003 | Biochemistry Mosc. | pmid:12765534 |
| Sasaki N et al. | Protective effects of flavonoids on the cytotoxicity of linoleic acid hydroperoxide toward rat pheochromocytoma PC12 cells. | 2003 | Chem. Biol. Interact. | pmid:12606158 |
| Ueda Y et al. | Effects on blood pressure decrease in response to PAF of Impatiens textori MIQ. | 2003 | Biol. Pharm. Bull. | pmid:14519965 |
| Sarno S et al. | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). | 2003 | Biochem. J. | pmid:12816539 |