apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Genomic Instability D042822 7 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
Chromosomal Instability D043171 5 associated lipids
Lymphoma, Primary Effusion D054685 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Authors Title Published Journal PubMed Link
Wei YX et al. [Studies on the chemical constituents of Gueldenstaedtia stenophylla]. 2007 Zhong Yao Cai pmid:18074843
Tan XQ et al. [Study on the flavonoids constituents of Trachelospermum jasminoides]. 2010 Zhong Yao Cai pmid:20518306
Wang JL et al. [Studies on the chemical constituents of Pharbitis purpurea]. 2010 Zhong Yao Cai pmid:21355193
Dai H et al. Scutellarin benzyl ester partially secured the ischemic injury by its anti-apoptosis mechanism in cardiomyocytes of neonatal rats. 2011 Zhong Xi Yi Jie He Xue Bao pmid:21906527
You HS et al. [Absorption and transportation characteristics of scutellarin and scutellarein across Caco-2 monolayer model]. 2010 Zhong Xi Yi Jie He Xue Bao pmid:20836977
Li C et al. Structure-activity relationship of 7 flavonoids on recombinant human protein kinase CK2 holoenzyme. 2009 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:19197122
Lin F et al. [Inhibitory effect of jianpi-jiedu prescription-contained serum on colorectal cancer SW48 cell proliferation by mTOR-P53-P21 signalling pathway]. 2016 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:27932756
Shu L et al. [Effects of apigenin on self-renewal and 
uPAR expression in NCI-H446 cell line]. 2016 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:27932755
Deng J et al. [Proliferation and apoptosis of choriocarcinoma cell JEG-3 induced by VB2 and its in vitro mechanism]. 2013 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:23719531
Luan LJ et al. [Determination of four effective components from total flavonoids of Scutellaria barbata by high performance liquid chromatography]. 2011 Zhejiang Da Xue Xue Bao Yi Xue Ban pmid:21319369