| MeSH term | MeSH ID | Detail |
|---|---|---|
| Genomic Instability | D042822 | 7 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kowalczyk A et al. | Insights into novel anticancer applications for apigenin. | 2017 | Adv Clin Exp Med | pmid:29211364 |
| Zhong Y et al. | Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. | 2017 | Toxicon | pmid:28734981 |
| Elhennawy MG and Lin HS | Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. | 2017 | J Pharm Biomed Anal | pmid:28494337 |
| Alvin JW and Lacy DB | Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. | 2017 | J. Struct. Biol. | pmid:28433497 |
| Hicks DF et al. | Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. | 2017 | Sci Rep | pmid:28256512 |
| Min JW et al. | Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. | 2017 | Oncotarget | pmid:28424420 |
| Perrott KM et al. | Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. | 2017 | Geroscience | pmid:28378188 |
| Stump TA et al. | The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. | 2017 | J. Pharm. Pharmacol. | pmid:28349530 |
| Sun XP et al. | Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. | 2017 | Arch. Pharm. Res. | pmid:28315259 |
| Ferrazzi P et al. | Pollination effects on antioxidant content of Perilla frutescens seeds analysed by NMR spectroscopy. | 2017 | Nat. Prod. Res. | pmid:28278651 |
| Naik PM and Al-Khayri JM | Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. | 2017 | Methods Mol. Biol. | pmid:28755356 |
| Grigalius I and Petrikaite V | Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. | 2017 | Molecules | pmid:29215574 |
| Granato M et al. | Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. | 2017 | J. Exp. Clin. Cancer Res. | pmid:29179721 |
| Fan H et al. | Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. | 2017 | Med. Sci. Monit. | pmid:29172017 |
| Gu C et al. | Preparation of Vitexin Nanoparticles by Combining the Antisolvent Precipitation and High Pressure Homogenization Approaches Followed by Lyophilization for Dissolution Rate Enhancement. | 2017 | Molecules | pmid:29165376 |
| Liao M et al. | Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29127056 |
| Medhat AM et al. | Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. | 2017 | Tumour Biol. | pmid:29022496 |
| Ganesan K and Xu B | Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. | 2017 | Ann. N. Y. Acad. Sci. | pmid:28891090 |
| Zhou RJ et al. | Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28867192 |
| Shan S et al. | Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. | 2017 | J. Agric. Food Chem. | pmid:28829588 |
| Britto SM et al. | Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. | 2017 | Mutat. Res. | pmid:28735741 |
| Wen L et al. | An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. | 2017 | Molecules | pmid:28486427 |
| Jangdey MS et al. | Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. | 2017 | Drug Deliv | pmid:28687053 |
| Perez-Leal O et al. | Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. | 2017 | J. Biol. Chem. | pmid:28684421 |
| Che Ahmad Tantowi NA et al. | Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. | 2017 | Menopause | pmid:28640163 |
| Li J et al. | Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. | 2017 | World J. Gastroenterol. | pmid:28611514 |
| Chen JL and Ko WC | Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. | 2017 | Eur. J. Pharmacol. | pmid:28603044 |
| Karim R et al. | Development and evaluation of injectable nanosized drug delivery systems for apigenin. | 2017 | Int J Pharm | pmid:28456651 |
| Soyman Z et al. | Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. | 2017 | Balkan Med J | pmid:28443590 |
| Zhao G et al. | Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. | 2017 | Oncol. Rep. | pmid:28260058 |
| Bolzon LB et al. | Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems. | 2017 | J. Inorg. Biochem. | pmid:28236787 |
| Liu HJ et al. | Apigenin alleviates STZ-induced diabetic cardiomyopathy. | 2017 | Mol. Cell. Biochem. | pmid:28176247 |
| Maher HM et al. | Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS. | 2017 | J Pharm Biomed Anal | pmid:28167419 |
| Wei X et al. | Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. | 2017 | Clin. Sci. | pmid:28143892 |
| Espargaró A et al. | Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. | 2017 | J. Nat. Prod. | pmid:28128562 |
| Zhou Z et al. | Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. | 2017 | Anticancer Drugs | pmid:28125432 |
| Erdogan S et al. | The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. | 2017 | Biomed. Pharmacother. | pmid:28107698 |
| Thirusangu P et al. | Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28104392 |
| Hithamani G et al. | Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells. | 2017 | J. Biosci. | pmid:29229878 |
| Tseng TH et al. | Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. | 2017 | Environ. Toxicol. | pmid:26872304 |
| Guo TT et al. | Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. | 2017 | J Asian Nat Prod Res | pmid:27848262 |
| Sharma N et al. | Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativus Targeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena. | 2017 | Med Chem | pmid:27834134 |
| Tang D et al. | Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. | 2017 | Expert Opin Drug Metab Toxicol | pmid:27766890 |
| Tan YQ et al. | Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. | 2017 | Mol. Cell. Biochem. | pmid:27778136 |
| Pápay ZE et al. | Controlled Release Oral Delivery of Apigenin Containing Pellets with Antioxidant Activity. | 2017 | Curr Drug Deliv | pmid:27264725 |
| Wong TY et al. | Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. | 2017 | Biomed. Pharmacother. | pmid:29198743 |
| Wang J et al. | Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. | 2017 | Int J Nanomedicine | pmid:29158673 |
| Hassan SM et al. | Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. | 2017 | Pharm Biol | pmid:28064632 |
| Salazar-Aguilar S et al. | Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. | 2017 | Nutrients | pmid:28757593 |
| Golea L et al. | Phytochemical components and biological activities of Silene arenarioides Desf. | 2017 | Nat. Prod. Res. | pmid:28278644 |