| MeSH term | MeSH ID | Detail |
|---|---|---|
| Genomic Instability | D042822 | 7 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sanderson JT et al. | Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. | 2004 | Toxicol. Sci. | pmid:15319488 |
| Jin UH et al. | Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. | 2018 | Toxicol. Sci. | pmid:29584932 |
| Alhusainy W et al. | Matrix modulation of the bioactivation of estragole by constituents of different alkenylbenzene-containing herbs and spices and physiologically based biokinetic modeling of possible in vivo effects. | 2012 | Toxicol. Sci. | pmid:22649189 |
| Hong H et al. | Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. | 2015 | Toxicol. Sci. | pmid:25349334 |
| Çelik H et al. | In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase. | 2013 | Toxicology | pmid:23567315 |
| Androutsopoulos VP et al. | CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells. | 2009 | Toxicology | pmid:19666078 |
| Chaudhary A and Willett KL | Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort. | 2006 | Toxicology | pmid:16271822 |
| Khan TH and Sultana S | Apigenin induces apoptosis in Hep G2 cells: possible role of TNF-alpha and IFN-gamma. | 2006 | Toxicology | pmid:16289292 |
| Zhong Y et al. | Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. | 2017 | Toxicon | pmid:28734981 |
| Yingprasertchai S et al. | Hyaluronidase inhibitors (sodium cromoglycate and sodium auro-thiomalate) reduce the local tissue damage and prolong the survival time of mice injected with Naja kaouthia and Calloselasma rhodostoma venoms. | 2003 | Toxicon | pmid:14602119 |
| Ibanez S et al. | Plant insecticidal toxins in ecological networks. | 2012 | Toxins (Basel) | pmid:22606374 |
| Huang H et al. | effects of natural flavonoids on photosynthetic activity and cell integrity in Microcystis aeruginosa. | 2015 | Toxins (Basel) | pmid:25584428 |
| Schrader KK | Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). | 2010 | Toxins (Basel) | pmid:22069655 |
| Ahlenstiel T et al. | Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions. | 2006 | Transplantation | pmid:16436967 |
| Medhat AM et al. | Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. | 2017 | Tumour Biol. | pmid:29022496 |
| Hassoun SM et al. | Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. | 2017 | Tumour Biol. | pmid:28651490 |
| Chen J et al. | The apoptotic effect of apigenin on human gastric carcinoma cells through mitochondrial signal pathway. | 2014 | Tumour Biol. | pmid:24805829 |
| Wan Y et al. | miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. | 2017 | Tumour Biol. | pmid:28381178 |
| Nasr-Bouzaiene N et al. | Immunomodulatory and cellular antioxidant activities of pure compounds from Teucrium ramosissimum Desf. | 2016 | Tumour Biol. | pmid:26692099 |
| Chen F et al. | An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. | 2017 | Ultrason Sonochem | pmid:28427633 |
| Kawamura H et al. | Ultrasonically enhanced extraction of luteolin and apigenin from the leaves of Perilla frutescens (L.) Britt. using liquid carbon dioxide and ethanol. | 2016 | Ultrason Sonochem | pmid:26584980 |
| Qin W et al. | Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose. | 2016 | Vascul. Pharmacol. | pmid:27473516 |
| Shibata C et al. | The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels. | 2014 | Virology | pmid:25092460 |
| Chang CW et al. | Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. | 2012 | Viruses | pmid:22590685 |
| Qian S et al. | Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity. | 2015 | Viruses | pmid:25835532 |
| Sui H et al. | [Effect of high dose apigenin on antioxidase activity and DNA damage in rats]. | 2009 | Wei Sheng Yan Jiu | pmid:19267072 |
| Sui H et al. | [Effects of apigenin on the expression of angiotensin-converting enzyme 2 in kidney in spontaneously hypertensive rats]. | 2010 | Wei Sheng Yan Jiu | pmid:21351633 |
| Sui H et al. | [Endothelium-dependent vasorelaxation effects induced by apigenin on the thoracic aorta of rats and its possible mechanism]. | 2011 | Wei Sheng Yan Jiu | pmid:21861336 |
| Kowalski J et al. | [Apigenin inhibits release and gene expression of monocyte chemoattractant protein 1 (MCP-1) in J774.2 macrophages]. | 2006 | Wiad. Lek. | pmid:17338120 |
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| Li J et al. | Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. | 2017 | World J. Gastroenterol. | pmid:28611514 |
| Wu K et al. | Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. | 2005 | World J. Gastroenterol. | pmid:16052672 |
| Hoensch H et al. | Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence. | 2008 | World J. Gastroenterol. | pmid:18407592 |
| Xu C et al. | Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines. | 2015 | Xenobiotica | pmid:25869249 |
| Galijatovic A et al. | Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. | 1999 | Xenobiotica | pmid:10647910 |
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| De Santi C et al. | Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. | 2000 | Xenobiotica | pmid:11055264 |
| Breinholt V et al. | Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. | 1999 | Xenobiotica | pmid:10647909 |
| Wang Y et al. | Intestinal transport of scutellarein and scutellarin and first-pass metabolism by UDP-glucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin. | 2011 | Xenobiotica | pmid:21561321 |
| Liang ZD et al. | [Effect of Apigenin on proliferation, cell cycle and apoptosis of mouse T cells in vitro]. | 2008 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:18394337 |
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| Qu LB et al. | [Interaction of bovine serum albumin with luteolin and apigenin]. | 2006 | Yao Xue Xue Bao | pmid:16856482 |