| MeSH term | MeSH ID | Detail |
|---|---|---|
| Genomic Instability | D042822 | 7 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pawlikowska-Pawlęga B et al. | FTIR, (1)H NMR and EPR spectroscopy studies on the interaction of flavone apigenin with dipalmitoylphosphatidylcholine liposomes. | 2013 | Biochim. Biophys. Acta | pmid:23088916 |
| Yi L et al. | Differential suppression of intracellular reactive oxygen species-mediated signaling pathway in vascular endothelial cells by several subclasses of flavonoids. | 2012 | Biochimie | pmid:22683914 |
| Tomaino A et al. | Antioxidant activity and phenolic profile of pistachio (Pistacia vera L., variety Bronte) seeds and skins. | 2010 | Biochimie | pmid:20388531 |
| Xiao J et al. | Molecular property-binding affinity relationship of flavonoids for common rat plasma proteins in vitro. | 2011 | Biochimie | pmid:20831890 |
| Choudhury D et al. | Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin. | 2013 | Biochimie | pmid:23485682 |
| Tsuchiya H et al. | Membrane-rigidifying effects of anti-cancer dietary factors. | 2002 | Biofactors | pmid:14530593 |
| Ashida H | Suppressive effects of flavonoids on dioxin toxicity. | 2000 | Biofactors | pmid:11216487 |
| Sahay A and Shakya M | Structure prediction of dihydroflavonol 4- reductase and anthocyanidin synthase from spinach. | 2010 | Bioinformation | pmid:21364828 |
| Kundu S and Roy D | Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation. | 2010 | Bioinformation | pmid:20978606 |
| Mishra S et al. | A molecular model for diacylglycerol acyltransferase from Mortierella ramanniana var. angulispora. | 2009 | Bioinformation | pmid:19759814 |
| Paris D et al. | Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism. | 2011 | Bioinformation | pmid:21738321 |
| Ganugapati J et al. | Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus. | 2012 | Bioinformation | pmid:22493522 |
| Tan M et al. | Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin. | 2009 | Bioinorg Chem Appl | pmid:19830248 |
| Eltayeb AA et al. | Antagonistic effect of scutellarin on the toxicity of selenium in rat livers. | 2004 | Biol Trace Elem Res | pmid:15131321 |
| Mo SF et al. | Hypouricemic action of selected flavonoids in mice: structure-activity relationships. | 2007 | Biol. Pharm. Bull. | pmid:17666819 |
| Mizoyama Y et al. | Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes. | 2004 | Biol. Pharm. Bull. | pmid:15340238 |
| Oku H et al. | Antipruritic effects of the fruits of Chaenomeles sinensis. | 2003 | Biol. Pharm. Bull. | pmid:12843634 |
| Lin YT et al. | Degradation of flavonoid aglycones by rabbit, rat and human fecal flora. | 2003 | Biol. Pharm. Bull. | pmid:12736527 |
| Nagao T et al. | Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. | 2002 | Biol. Pharm. Bull. | pmid:12132661 |
| Makino T et al. | Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. | 2001 | Biol. Pharm. Bull. | pmid:11642335 |
| Nakazawa T et al. | Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test. | 2003 | Biol. Pharm. Bull. | pmid:12673028 |
| Chatuphonprasert W et al. | Potent modification of inducible CYP1A1 expression by flavonoids. | 2010 | Biol. Pharm. Bull. | pmid:20930378 |
| Woo ER et al. | Inhibition of nuclear factor-kappaB activation by 2',8''-biapigenin. | 2006 | Biol. Pharm. Bull. | pmid:16651730 |
| Tian X et al. | Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C. | 2016 | Biol. Pharm. Bull. | pmid:26581323 |
| Nakazawa T and Ohsawa K | Metabolites of orally administered Perilla frutescens extract in rats and humans. | 2000 | Biol. Pharm. Bull. | pmid:10706426 |
| Morimitsu Y et al. | Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. | 2004 | Biol. Pharm. Bull. | pmid:15133252 |
| Tai ZF et al. | Identification of small molecule activators of the janus kinase/signal transducer and activator of transcription pathway using a cell-based screen. | 2012 | Biol. Pharm. Bull. | pmid:22223339 |
| Nakamura K et al. | Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. | 2015 | Biol. Pharm. Bull. | pmid:25810454 |
| Kim DH et al. | Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells. | 2008 | Biol. Pharm. Bull. | pmid:18239283 |
| Ji P et al. | Antiviral activity of Paulownia tomentosa against enterovirus 71 of hand, foot, and mouth disease. | 2015 | Biol. Pharm. Bull. | pmid:25744451 |
| Hasegawa E et al. | Effect of polyphenols on production of steroid hormones from human adrenocortical NCI-H295R cells. | 2013 | Biol. Pharm. Bull. | pmid:23370353 |
| Matsuo M et al. | Cytotoxicity of flavonoids toward cultured normal human cells. | 2005 | Biol. Pharm. Bull. | pmid:15684479 |
| Iwaoka E et al. | Allergy-preventive effects of the flowers of Impatiens textori. | 2010 | Biol. Pharm. Bull. | pmid:20410612 |
| Amakura Y et al. | Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. | 2003 | Biol. Pharm. Bull. | pmid:14646185 |
| Wohlmuth H et al. | Pharmacognosy and chemotypes of passionflower (Passiflora incarnata L.). | 2010 | Biol. Pharm. Bull. | pmid:20522969 |
| Tai BH et al. | Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis. | 2009 | Biol. Pharm. Bull. | pmid:19952410 |
| Han JY et al. | Protection of apigenin against kainate-induced excitotoxicity by anti-oxidative effects. | 2012 | Biol. Pharm. Bull. | pmid:22975493 |
| Suh KS et al. | Apigenin attenuates 2-deoxy-D-ribose-induced oxidative cell damage in HIT-T15 pancreatic β-cells. | 2012 | Biol. Pharm. Bull. | pmid:22223348 |
| Muanprasat C et al. | Identification of new small molecule inhibitors of cystic fibrosis transmembrane conductance regulator protein: in vitro and in vivo studies. | 2007 | Biol. Pharm. Bull. | pmid:17329846 |
| Ueda Y et al. | Antianaphylactic and antipruritic effects of the flowers of Impatiens textori MIQ. | 2005 | Biol. Pharm. Bull. | pmid:16141562 |
| Li W et al. | Antihyperglycemic effect of Cephalotaxus sinensis leaves and GLUT-4 translocation facilitating activity of its flavonoid constituents. | 2007 | Biol. Pharm. Bull. | pmid:17541165 |
| Nomura M et al. | Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells. | 2008 | Biol. Pharm. Bull. | pmid:18591783 |
| Ueda Y et al. | Effects on blood pressure decrease in response to PAF of Impatiens textori MIQ. | 2003 | Biol. Pharm. Bull. | pmid:14519965 |
| Simeonova R et al. | Hepatoprotective and antioxidant effects of saponarin, isolated from Gypsophila trichotoma Wend. on paracetamol-induced liver damage in rats. | 2013 | Biomed Res Int | pmid:23878818 |
| Liu L et al. | Effect of luteolin and apigenin on the expression of Oct-4, Sox2, and c-Myc in dental pulp cells with in vitro culture. | 2015 | Biomed Res Int | pmid:25815323 |
| Paramaguru R et al. | Antidiabetic activity of Pterospermum acerifolium flowers and glucose uptake potential of bioactive fraction in L6 muscle cell lines with its HPLC fingerprint. | 2014 | Biomed Res Int | pmid:25401101 |
| Vamanu E | Antioxidant properties of mushroom mycelia obtained by batch cultivation and tocopherol content affected by extraction procedures. | 2014 | Biomed Res Int | pmid:25110715 |
| Tsalkidou EG et al. | The effects of apigenin on the expression of Fas/FasL apoptotic pathway in warm liver ischemia-reperfusion injury in rats. | 2014 | Biomed Res Int | pmid:25110657 |
| Liu XY et al. | The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. | 2013 | Biomed Res Int | pmid:24369535 |
| Muhammad AA et al. | In vitro wound healing potential and identification of bioactive compounds from Moringa oleifera Lam. | 2013 | Biomed Res Int | pmid:24490175 |