| MeSH term | MeSH ID | Detail |
|---|---|---|
| Genomic Instability | D042822 | 7 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen M et al. | Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner. | 2016 | Sci Rep | pmid:27752089 |
| El-Alfy TS et al. | A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. | 2011 Oct-Dec | Sci Pharm | pmid:22145118 |
| Brown JS | Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: an endocrine-disruption theory of schizophrenia. | 2009 | Schizophr Bull | pmid:18245062 |
| Bai H et al. | Apigenin induced MCF-7 cell apoptosis-associated reactive oxygen species. | Scanning | pmid:25327419 | |
| Zhu H et al. | Apigenin induced apoptosis in esophageal carcinoma cells by destruction membrane structures. | 2016 | Scanning | pmid:26435325 |
| Avwioro OG et al. | Collagen and muscle stain obtained from Sorghum bicolor. | 2006 | Scand. J. Clin. Lab. Invest. | pmid:16537249 |
| Tsaroucha AK et al. | Intraperitoneal administration of apigenin in liver ischemia/reperfusion injury protective effects. | 2016 | Saudi J Gastroenterol | pmid:27976636 |
| Sidibé el H | [Thyroid diseases in sub-Saharan Africa]. | 2007 Jan-Mar | Sante | pmid:17897900 |
| Della Loggia R et al. | [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. | 1981 Sep-Oct | Riv Neurol | pmid:6118937 |
| Jun JB et al. | Dietary flavonoid apigenin inhibits endothelin-1-induced contraction of collagen gel. | 2010 | Rheumatol. Int. | pmid:20012048 |
| Shahi J and Singh A | Effect of bioactive compounds extracted from euphorbious plants on hematological and biochemical parameters of Channa punctatus. | 2011 Sep-Oct | Rev. Inst. Med. Trop. Sao Paulo | pmid:22012451 |
| de Font-Réaulx Rojas E and Dorazco-Barragan G | [Clinical stabilisation in neurodegenerative diseases: clinical study in phase II]. | 2010 | Rev Neurol | pmid:20443170 |
| Hanganu D et al. | The study of some polyphenolic compounds from Melissa officinalis L. (Lamiaceae). | 2008 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:19295032 |
| Hirano T et al. | Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2749004 |
| Stroheker T et al. | Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats: a comparative study. | 2003 Jul-Aug | Reprod. Toxicol. | pmid:12849853 |
| van Vugt-Lussenburg BMA et al. | Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity. | 2018 | Reprod. Toxicol. | pmid:29162470 |
| Wang X et al. | Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro. | 2018 | Ren Fail | pmid:30278824 |
| Kandhare AD et al. | Acute and repeated doses (28 days) oral toxicity study of Vicenin-1, a flavonoid glycoside isolated from fenugreek seeds in laboratory mice. | 2016 | Regul. Toxicol. Pharmacol. | pmid:27773753 |
| Li X et al. | Acute and subacute toxicological evaluation of scutellarin in rodents. | 2011 | Regul. Toxicol. Pharmacol. | pmid:21382428 |
| Vitcheva V et al. | Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. | 2011 | Redox Rep. | pmid:21722413 |
| Banerjee K and Mandal M | Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells. | 2015 | Redox Biol | pmid:25965143 |
| Taupin P | Neurogenic drugs and compounds. | 2010 | Recent Pat CNS Drug Discov | pmid:20636273 |
| Sikorska M et al. | Application of mass spectrometric techniques for structural analysis of apigenin 8-C-(6"-O-glucopyranosyl) glucopyranoside--a novel flavonoid C-diglycoside. | 2003 | Rapid Commun. Mass Spectrom. | pmid:12811762 |
| Cavaliere C et al. | Identification and mass spectrometric characterization of glycosylated flavonoids in Triticum durum plants by high-performance liquid chromatography with tandem mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:16200659 |
| Abad-GarcÃa B et al. | New features on the fragmentation and differentiation of C-glycosidic flavone isomers by positive electrospray ionization and triple quadrupole mass spectrometry. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18470889 |
| Madeira PJ et al. | Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric and semi-empirical calculations study of five isoflavone aglycones. | 2010 | Rapid Commun. Mass Spectrom. | pmid:21072799 |
| Ferreres F et al. | Approach to the study of C-glycosyl flavones acylated with aliphatic and aromatic acids from Spergularia rubra by high-performance liquid chromatography-photodiode array detection/electrospray ionization multi-stage mass spectrometry. | 2011 | Rapid Commun. Mass Spectrom. | pmid:21337631 |
| Flamini R and Dalla Vedova A | Fast determination of the total free resveratrol content in wine by direct-exposure-probe, positive-ion chemical ionization and collision-induced-dissociation mass spectrometry. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15329858 |
| Uma Devi P et al. | Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. | 2000 | Radiat. Res. | pmid:11023610 |
| Uma Devi P et al. | In vivo radioprotection by ocimum flavonoids: survival of mice. | 1999 | Radiat. Res. | pmid:9973087 |
| Nayak V and Devi PU | Protection of mouse bone marrow against radiation-induced chromosome damage and stem cell death by the ocimum flavonoids orientin and vicenin. | 2005 | Radiat. Res. | pmid:15658892 |
| Johannot L and Somerset SM | Age-related variations in flavonoid intake and sources in the Australian population. | 2006 | Public Health Nutr | pmid:17125569 |
| Barlak Y et al. | Effect of Turkish propolis extracts on proteome of prostate cancer cell line. | 2011 | Proteome Sci | pmid:22152088 |
| Zhang L et al. | Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay. | 2008 | Protein Sci. | pmid:18780820 |
| Morrissey C et al. | Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells. | 2005 | Prostate | pmid:15486995 |
| Jiang JG et al. | Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17164144 |
| Kiraly AJ et al. | Apigenin inhibits COX-2, PGE2, and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26802941 |
| Safari MR and Sheikh N | Effects of flavonoids on the susceptibility of low-density lipoprotein to oxidative modification. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878454 |
| Lyckander IM and Malterud KE | Lipophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lipoxygenase. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804120 |
| Kim HR et al. | Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A2. | 2001 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11993721 |
| Arango D et al. | Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23697369 |
| Cai X and Liu X | Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18952844 |
| Rebholz H et al. | CK2 negatively regulates Galphas signaling. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19666609 |
| Chockalingam K et al. | A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20142494 |
| Yamada M et al. | Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15897466 |
| Sainis I et al. | PPARgamma: The Portrait of a Target Ally to Cancer Chemopreventive Agents. | 2008 | PPAR Res | pmid:18779870 |
| Xin DW et al. | Functional analysis of NopM, a novel E3 ubiquitin ligase (NEL) domain effector of Rhizobium sp. strain NGR234. | 2012 | PLoS Pathog. | pmid:22615567 |
| Xiao J et al. | The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm. | 2012 | PLoS Pathog. | pmid:22496649 |
| Madhani HD | Quorum sensing in fungi: Q&A. | 2011 | PLoS Pathog. | pmid:22046125 |
| Hirayama Y et al. | Mycobacteria exploit host hyaluronan for efficient extracellular replication. | 2009 | PLoS Pathog. | pmid:19876387 |