| MeSH term | MeSH ID | Detail |
|---|---|---|
| Genomic Instability | D042822 | 7 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| O'Prey J et al. | Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. | 2003 | Biochem. Pharmacol. | pmid:14609732 |
| Mateos R et al. | Antioxidant effect of phenolic compounds, alpha-tocopherol, and other minor components in virgin olive oil. | 2003 | J. Agric. Food Chem. | pmid:14611189 |
| Exarchou V et al. | LC-UV-solid-phase extraction-NMR-MS combined with a cryogenic flow probe and its application to the identification of compounds present in Greek oregano. | 2003 | Anal. Chem. | pmid:14616013 |
| Liu H et al. | Protective effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes. | 2003 | Acta Pharmacol. Sin. | pmid:14627495 |
| Liu Y et al. | Enteric disposition and recycling of flavonoids and ginkgo flavonoids. | 2003 | J Altern Complement Med | pmid:14629841 |
| Zhang S et al. | Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. | 2003 | Environ. Health Perspect. | pmid:14644660 |
| Amakura Y et al. | Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. | 2003 | Biol. Pharm. Bull. | pmid:14646185 |
| Gharzouli K and Holzer P | Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin and genistein. | 2004 | Pharmacology | pmid:14646351 |
| Jarry H et al. | Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones. | 2003 | Planta Med. | pmid:14648399 |
| Li H et al. | [Studies on chemical constituents from Phyllostachys pubescens]. | 2003 | Zhong Yao Cai | pmid:14649200 |
| Pikulski M and Brodbelt JS | Differentiation of flavonoid glycoside isomers by using metal complexation and electrospray ionization mass spectrometry. | 2003 | J. Am. Soc. Mass Spectrom. | pmid:14652191 |
| Hien TV et al. | Radioprotective effects of vitexina for breast cancer patients undergoing radiotherapy with cobalt-60. | 2002 | Integr Cancer Ther | pmid:14664747 |
| Takano-Ishikawa Y et al. | Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. | 2003 | Phytother Res | pmid:14669262 |
| Boué SM and Raina AK | Effects of plant flavonoids on fecundity, survival, and feeding of the Formosan subterranean termite. | 2003 | J. Chem. Ecol. | pmid:14682534 |
| Wang LS et al. | Chemical taxonomy of the Xibei tree peony from China by floral pigmentation. | 2004 | J. Plant Res. | pmid:14685820 |
| Dhawan K | Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective. | 2003 | Addict Biol | pmid:14690874 |
| Simirgiotis MJ et al. | New dammarane triterpenes from the aerial parts of Ibicella lutea grown in Argentina. | 2003 | J. Nat. Prod. | pmid:14695802 |
| Dias C et al. | Structural elucidation of natural 2-hydroxy di- and tricarboxylic acids and esters, phenylpropanoid esters and a flavonoid from Autonoë madeirensis using gas chromatographic/electron ionization, electrospray ionization and tandem mass spectrometric techniques. | 2003 | J Mass Spectrom | pmid:14696202 |
| Gradolatto A et al. | Metabolism of apigenin by rat liver phase I and phase ii enzymes and by isolated perfused rat liver. | 2004 | Drug Metab. Dispos. | pmid:14709621 |
| Li S et al. | [Pharmacokinetics of scutellarin in rabbits]. | 2003 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | pmid:14716879 |
| Cushnie TP et al. | Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports. | 2003 | Microbiol. Res. | pmid:14717448 |
| Liu YM et al. | Study on pharmacokinetics of scutellarin in rabbits. | 2003 | Yao Xue Xue Bao | pmid:14730903 |
| Gil-Izquierdo A et al. | Effect of the rootstock and interstock grafted in lemon tree (Citrus limon (L.) Burm.) on the flavonoid content of lemon juice. | 2004 | J. Agric. Food Chem. | pmid:14733516 |
| Ueda H et al. | A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745173 |
| Beyer G and Melzig MF | Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells. | 2003 | Planta Med. | pmid:14750029 |
| Kim AR et al. | Active components from Artemisia iwayomogi displaying ONOO(-) scavenging activity. | 2004 | Phytother Res | pmid:14750192 |
| Shukla S and Gupta S | Molecular mechanisms for apigenin-induced cell-cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells. | 2004 | Mol. Carcinog. | pmid:14750216 |
| Niisato N et al. | Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells. | 2004 | Biochem. Pharmacol. | pmid:14757180 |
| van Lipzig MM et al. | Prediction of ligand binding affinity and orientation of xenoestrogens to the estrogen receptor by molecular dynamics simulations and the linear interaction energy method. | 2004 | J. Med. Chem. | pmid:14761204 |
| Kosalec I et al. | Analysis of propolis from the continental and Adriatic regions of Croatia. | 2003 | Acta Pharm | pmid:14769234 |
| Bhat-Nakshatri P et al. | Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function. | 2004 | Br. J. Cancer | pmid:14970864 |
| Fonseca FN and Tavares MF | Validation of a capillary electrophoresis method for the quantitative determination of free and total apigenin in extracts of Chamomilla recutita. | 2004 Jan-Feb | Phytochem Anal | pmid:14979529 |
| Kuronuma K et al. | Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A. | 2004 | J. Biol. Chem. | pmid:14993215 |
| Czyz J et al. | Hierarchy of carcinoma cell responses to apigenin: gap junctional coupling versus proliferation. | 2004 | Oncol. Rep. | pmid:15010866 |
| Ko HH et al. | Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15013012 |
| Cheng YB et al. | [Study on chemical constituents in rhizome of Smilax perfoliate]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015307 |
| Báthori M et al. | Monitoring the antioxidant activity of extracts originated from various Serratula species and isolation of flavonoids from Serratula coronata. | 2004 | Fitoterapia | pmid:15030920 |
| Sonoda M et al. | Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. | 2004 | J Ethnopharmacol | pmid:15036470 |
| Maliar T et al. | Structural aspects of flavonoids as trypsin inhibitors. | 2004 | Eur J Med Chem | pmid:15051172 |
| Hong H and Liu GQ | Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin. | 2004 | Life Sci. | pmid:15051420 |
| Li HH et al. | Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. | 2004 | Mol. Cell | pmid:15053879 |
| Wang SP and Huang KJ | Determination of flavonoids by high-performance liquid chromatography and capillary electrophoresis. | 2004 | J Chromatogr A | pmid:15065805 |
| Garnovskaya MN et al. | Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation. | 2004 | J. Biol. Chem. | pmid:15069084 |
| Schinor EC et al. | Trypanocidal and antimicrobial activities of Moquinia kingii. | 2004 | Phytomedicine | pmid:15070176 |
| Schröder-van der Elst JP et al. | Differential effects of natural flavonoids on growth and iodide content in a human Na*/I- symporter-transfected follicular thyroid carcinoma cell line. | 2004 | Eur. J. Endocrinol. | pmid:15080787 |
| Kang SS et al. | Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15081021 |
| SvehlÃková V et al. | Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells. | 2004 | Carcinogenesis | pmid:15090468 |
| Scuro LS et al. | Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation. | 2004 | BMC Biochem. | pmid:15102332 |
| van Meeteren ME et al. | Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease. | 2004 | Biochem. Pharmacol. | pmid:15104250 |
| Li Y et al. | Acetylated flavonoid glycosides potentiating NGF action from Scoparia dulcis. | 2004 | J. Nat. Prod. | pmid:15104516 |