| MeSH term | MeSH ID | Detail |
|---|---|---|
| Genomic Instability | D042822 | 7 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nurdiana S et al. | Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. | 2017 | BMC Complement Altern Med | pmid:28576138 |
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| Mangoyi R et al. | Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri. | 2015 | BMC Complement Altern Med | pmid:26573005 |
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| Xu LW et al. | Chinese herb mix Tiáo-GÄ“ng-TÄng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats. | 2011 | BMC Complement Altern Med | pmid:22206438 |
| Alam N et al. | High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis. | 2011 | BMC Complement Altern Med | pmid:21854608 |
| Tang LI et al. | Screening of anti-dengue activity in methanolic extracts of medicinal plants. | 2012 | BMC Complement Altern Med | pmid:22244370 |
| Liberio SA et al. | Antimicrobial activity against oral pathogens and immunomodulatory effects and toxicity of geopropolis produced by the stingless bee Melipona fasciculata Smith. | 2011 | BMC Complement Altern Med | pmid:22053900 |
| Zick SM et al. | Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. | 2011 | BMC Complement Altern Med | pmid:21939549 |
| Sahreen S et al. | Comprehensive assessment of phenolics and antiradical potential of Rumex hastatus D. Don. roots. | 2014 | BMC Complement Altern Med | pmid:24507200 |
| Lans C et al. | Medicinal and ethnoveterinary remedies of hunters in Trinidad. | 2001 | BMC Complement Altern Med | pmid:11737880 |
| Ghashm AA et al. | Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines. | 2010 | BMC Complement Altern Med | pmid:20840769 |
| Nassiri-Asl M et al. | Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. | 2007 | BMC Complement Altern Med | pmid:17686156 |
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| Rahman S et al. | In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines. | 2011 | BMC Complement Altern Med | pmid:21933433 |
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| Pérez-Montaño F et al. | RNA-seq analysis of the Rhizobium tropici CIAT 899 transcriptome shows similarities in the activation patterns of symbiotic genes in the presence of apigenin and salt. | 2016 | BMC Genomics | pmid:26951045 |
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| Aviel-Ronen S et al. | Large fragment Bst DNA polymerase for whole genome amplification of DNA from formalin-fixed paraffin-embedded tissues. | 2006 | BMC Genomics | pmid:17156491 |
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| Jeon JG et al. | Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms. | 2009 | BMC Microbiol. | pmid:19863808 |
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| Fang M et al. | Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats. | 2015 | BMC Neurosci | pmid:26608466 |
| Yuan Y et al. | Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia. | 2014 | BMC Neurosci | pmid:25416145 |
| Ahn SH et al. | Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons. | 2011 | BMC Neurosci | pmid:21810275 |
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| Comino C et al. | Isolation and functional characterization of a cDNA coding a hydroxycinnamoyltransferase involved in phenylpropanoid biosynthesis in Cynara cardunculus L. | 2007 | BMC Plant Biol. | pmid:17374149 |
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| Mizuno H et al. | Expression level of a flavonoid 3'-hydroxylase gene determines pathogen-induced color variation in sorghum. | 2014 | BMC Res Notes | pmid:25346182 |
| Lehane AM and Saliba KJ | Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite. | 2008 | BMC Res Notes | pmid:18710482 |
| Boskey AL et al. | Modulation of extracellular matrix protein phosphorylation alters mineralization in differentiating chick limb-bud mesenchymal cell micromass cultures. | 2008 | Bone | pmid:18396125 |
| Guerrero JA et al. | Flavonoids inhibit the platelet TxA(2) signalling pathway and antagonize TxA(2) receptors (TP) in platelets and smooth muscle cells. | 2007 | Br J Clin Pharmacol | pmid:17425630 |
| Bhat-Nakshatri P et al. | Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function. | 2004 | Br. J. Cancer | pmid:14970864 |
| Jones DJ et al. | Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity. | 2004 | Br. J. Cancer | pmid:15292928 |
| Peterson J et al. | Flavonoid intake and breast cancer risk: a case--control study in Greece. | 2003 | Br. J. Cancer | pmid:14520456 |
| Cai H et al. | Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo. | 2004 | Br. J. Cancer | pmid:15316567 |
| Wang W et al. | 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action. | 2008 | Br. J. Cancer | pmid:18253123 |
| Domingo-Domenech J et al. | Activation of nuclear factor-kappaB in human prostate carcinogenesis and association to biochemical relapse. | 2005 | Br. J. Cancer | pmid:16278667 |
| Song DH et al. | Gastrin stabilises beta-catenin protein in mouse colorectal cancer cells. | 2005 | Br. J. Cancer | pmid:15798764 |
| Lordan S et al. | Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells. | 2008 | Br. J. Nutr. | pmid:18186953 |
| Cao J et al. | The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake. | 2010 | Br. J. Nutr. | pmid:19747418 |
| Jeong YJ et al. | Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids. | 2005 | Br. J. Nutr. | pmid:15975156 |
| Dell'Agli M et al. | Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase. | 2008 | Br. J. Nutr. | pmid:17927845 |
| Jeong YJ et al. | Attenuation of monocyte adhesion and oxidised LDL uptake in luteolin-treated human endothelial cells exposed to oxidised LDL. | 2007 | Br. J. Nutr. | pmid:17313705 |