| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Cocaine-Related Disorders | D019970 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hirayama Y et al. | Mycobacteria exploit host hyaluronan for efficient extracellular replication. | 2009 | PLoS Pathog. | pmid:19876387 |
| Hunyadi A et al. | Direct semi-synthesis of the anticancer lead-drug protoapigenone from apigenin, and synthesis of further new cytotoxic protoflavone derivatives. | 2011 | PLoS ONE | pmid:21912610 |
| Oishi M et al. | Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2. | 2013 | PLoS ONE | pmid:23431365 |
| Veltmann M et al. | Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. | 2016 | PLoS ONE | pmid:26800359 |
| Kesavan R et al. | Inhibition of vascular smooth muscle cell proliferation by Gentiana lutea root extracts. | 2013 | PLoS ONE | pmid:23637826 |
| Yang Y et al. | Plant food delphinidin-3-glucoside significantly inhibits platelet activation and thrombosis: novel protective roles against cardiovascular diseases. | 2012 | PLoS ONE | pmid:22624015 |
| Chen G et al. | Investigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17βHSD7 gene expression. | 2012 | PLoS ONE | pmid:23300627 |
| Bauer D et al. | Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. | 2017 | PLoS ONE | pmid:28441391 |
| Nelson N et al. | Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer. | 2017 | PLoS ONE | pmid:28152014 |
| Wang P et al. | Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols. | 2010 | PLoS ONE | pmid:20419137 |
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| Zhang L et al. | Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans. | 2011 | PLoS ONE | pmid:22174935 |
| Gentile D et al. | The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. | 2018 | PLoS ONE | pmid:29641549 |
| Wang W et al. | Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor. | 2016 | PLoS ONE | pmid:26730961 |
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| Willenberg I et al. | Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity. | 2015 | PLoS ONE | pmid:26440517 |
| Li H et al. | Potentiation of scutellarin on human tongue carcinoma xenograft by low-intensity ultrasound. | 2013 | PLoS ONE | pmid:23536878 |
| Shukla S et al. | Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice. | 2015 | PLoS ONE | pmid:26379052 |
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| Zhang W et al. | Apigenin inhibits enterovirus-71 infection by disrupting viral RNA association with trans-acting factors. | 2014 | PLoS ONE | pmid:25330384 |
| Cheah HL et al. | Inhibitors of the glyoxylate cycle enzyme ICL1 in Candida albicans for potential use as antifungal agents. | 2014 | PLoS ONE | pmid:24781056 |
| Zhang X et al. | Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages. | 2014 | PLoS ONE | pmid:25192391 |
| Srinivasa V et al. | Novel apigenin based small molecule that targets snake venom metalloproteases. | 2014 | PLoS ONE | pmid:25184206 |
| Bumke-Vogt C et al. | The flavones apigenin and luteolin induce FOXO1 translocation but inhibit gluconeogenic and lipogenic gene expression in human cells. | 2014 | PLoS ONE | pmid:25136826 |
| Jiang NH et al. | Analysis of the transcriptome of Erigeron breviscapus uncovers putative scutellarin and chlorogenic acids biosynthetic genes and genetic markers. | 2014 | PLoS ONE | pmid:24956277 |
| Leo CH et al. | 3',4'-Dihydroxyflavonol reduces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries. | 2011 | PLoS ONE | pmid:21673968 |
| Joseph J et al. | High throughput ratio imaging to profile caspase activity: potential application in multiparameter high content apoptosis analysis and drug screening. | 2011 | PLoS ONE | pmid:21637712 |
| Liao Y et al. | Apigenin induces the apoptosis and regulates MAPK signaling pathways in mouse macrophage ANA-1 cells. | 2014 | PLoS ONE | pmid:24646936 |
| Sharma H et al. | Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells. | 2014 | PLoS ONE | pmid:24614817 |
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